Terbinafine (250mg), marketed under the brand name TURBOFINE 250, is a powerful antifungal medication used to treat various fungal infections. This article delves into how Terbinafine works, its uses, potential side effects, and why it is a crucial medication in dermatology.

How Does Terbinafine Work?

Terbinafine operates by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes. This action disrupts the cell membrane's integrity, leading to fungal cell death.

• Inhibits Ergosterol Synthesis: Terbinafine targets the enzyme squalene epoxidase, crucial for ergosterol production.
• Disrupts Fungal Cell Membrane: By depleting ergosterol, Terbinafine compromises the fungal cell membrane, causing cell death.
• Broad-Spectrum Activity: Effective against a wide range of dermatophytes, yeasts, and molds.

Uses of Terbinafine

Terbinafine is primarily used to treat fungal infections affecting the skin, hair, and nails.

• Onychomycosis: Effective in treating fungal nail infections, promoting healthy nail growth.
• Tinea Pedis: Commonly prescribed for athlete's foot, a fungal infection of the feet.
• Tinea Corporis: Used for ringworm infections on various parts of the body.
• Tinea Cruris: Treats jock itch, a fungal infection of the groin area.

What is TURBOFINE 250?

TURBOFINE 250 is a branded formulation of Terbinafine, designed for oral administration. Each tablet contains 250mg of Terbinafine hydrochloride.

• Dosage: Typically, one tablet per day for adults, the duration depends on the infection type and severity.
• Administration: Oral tablets should be taken with water, with or without food.

Side Effects of Terbinafine

While Terbinafine is generally well-tolerated, it can cause side effects in some individuals.

• Common Side Effects:
  • Gastrointestinal Issues: Nausea, diarrhea, and abdominal pain.
  • Skin Reactions: Rash, itching, or hives.
  • Headache: Mild to moderate headache is common.
• Serious Side Effects:
  • Liver Toxicity: Rare but serious, indicated by jaundice, dark urine, or upper right abdominal pain.
  • Severe Skin Reactions: Stevens-Johnson syndrome or toxic epidermal necrolysis, though extremely rare.
  • Allergic Reactions: Swelling of the face, lips, tongue, or throat requiring immediate medical attention.

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