(5mg) Methotrexate

Introduction

METROTREX 5 is a clinically established formulation containing Methotrexate 5mg, a potent antimetabolite and immunosuppressant used in the treatment of autoimmune disorders, inflammatory conditions, and certain cancers. Known for its ability to slow disease progression and suppress overactive immune responses, Methotrexate is one of the most prescribed drugs globally for long-term conditions like rheumatoid arthritis, psoriasis, and leukemia.

Key Features & Composition

• Brand Name: METROTREX 5

• Active Ingredient: Methotrexate 5mg

• Drug Class: Antimetabolite, Immunosuppressive Agent, DMARD

• Form: Oral Tablet

• Manufacturing Standard: WHO-GMP, ISO Certified

Therapeutic Uses of METROTREX 5

 Rheumatoid Arthritis

Helps reduce joint pain, inflammation, and delays joint damage.

 Psoriasis and Psoriatic Arthritis

Controls skin lesions and joint stiffness by targeting immune cell overactivity.

 Certain Cancers

Prescribed in the management of:

• Leukemia (especially Acute Lymphoblastic Leukemia)

• Non-Hodgkin’s Lymphoma

• Breast and Lung Cancer

• Trophoblastic Neoplasms

 Crohn’s Disease and Systemic Lupus Erythematosus (SLE) (off-label use)

How Methotrexate Works

Methotrexate inhibits the enzyme dihydrofolate reductase (DHFR), blocking the synthesis of DNA, RNA, and proteins in rapidly dividing cells. This action helps:

• Stop autoimmune cell activity in diseases like arthritis and psoriasis

• Inhibit cancer cell growth and replication

Benefits of METROTREX 5

• Effective in weekly low-dose regimens

• Reduces reliance on long-term steroid use

• Improves quality of life in chronic autoimmune patients

• Safe for long-term use under medical supervision

• Cost-effective and accessible therapy for low-income patients

• Manufactured with pharma-grade precision

Recommended Dosage & Administration

• Autoimmune disorders: Typically once a week (never daily unless specifically advised)

• Cancer therapy: Dosing may be more frequent, depending on treatment protocol

Precautions & Safety Guidelines

• Contraindicated in pregnancy and breastfeeding

• Requires frequent monitoring of liver, kidney, and blood parameters

• Avoid alcohol and NSAIDs unless approved by a doctor

• Take Folic Acid supplements alongside Methotrexate to reduce side effects

• Report any signs of fever, sore throat, or unusual bleeding

Possible Side Effects

Common:

• Nausea and vomiting

• Mouth ulcers

• Fatigue

• Hair thinning

• Abdominal discomfort

Serious:

• Liver toxicity

• Bone marrow suppression

• Lung inflammation (pneumonitis)

• Kidney dysfunction

Storage Instructions

• Store at room temperature below 25°C

• Keep away from light and moisture

• Ensure childproof storage

FAQs – METROTREX 5

Q1. What is METROTREX 5 used for?

It is used for treating rheumatoid arthritis, psoriasis, and certain types of cancer.

Q2. Is Methotrexate safe for long-term use?

Yes, when monitored properly with regular blood tests, Methotrexate is safe and effective for long-term therapy.

Q3. Can I take Methotrexate daily?

No. Methotrexate is usually prescribed once a week for autoimmune disorders. Daily intake can be dangerous.

Q4. Why is folic acid prescribed with Methotrexate?

To reduce the risk of mouth sores, nausea, and liver toxicity.

Q5. What are the signs of Methotrexate toxicity?

Symptoms may include vomiting, mouth ulcers, low blood count, or breathing issues. Always inform your doctor immediately.

Conclusion

METROTREX 5 (Methotrexate 5mg) is a gold-standard, cost-effective option for treating autoimmune diseases and cancers. With proper dosing and medical oversight, it provides long-term relief and improved health outcomes. It’s a valuable addition to chronic care protocols, especially in rheumatology and oncology.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

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