ABIRASTERON 250. Uses, Dosage, and Side Effects - Steris Healthcare PVT LTD.....

ABIRASTERON 250

Abiraterone Acetate lp (250mg)

ABIRASTERON 250 is a pharmaceutical product containing Abiraterone Acetate (250mg), which is primarily used in the treatment of prostate cancer. This medication works by inhibiting the production of androgens (male hormones) that can stimulate the growth of cancer cells in the prostate. Abiraterone Acetate is often prescribed alongside other treatments to enhance its effectiveness and manage advanced stages of prostate cancer.

Uses of ABIRASTERON 250

Treatment of Prostate Cancer

• Advanced Prostate Cancer: ABIRASTERON 250 is used to treat patients with metastatic castration-resistant prostate cancer (mCRPC) who have either undergone surgical treatment or other therapies.
• Hormone-Sensitive Prostate Cancer: It is also effective in treating newly diagnosed high-risk metastatic hormone-sensitive prostate cancer (mHSPC).

Mechanism of Action

• Inhibition of CYP17: Abiraterone Acetate works by inhibiting the enzyme CYP17, which is crucial for the production of androgens in the testes, adrenal glands, and prostate tumor tissue.
• Reduction of Androgen Levels: By blocking androgen production, ABIRASTERON 250 reduces the levels of testosterone and other androgens in the body, slowing the growth of prostate cancer cells.

Dosage and Administration

Recommended Dosage

• The standard dosage of ABIRASTERON 250 is four tablets (1000mg) taken once daily on an empty stomach. It is essential to avoid food intake for at least two hours before and one hour after taking the medication to ensure proper absorption.

Administration Guidelines

• With Prednisone or Prednisolone: ABIRASTERON 250 is typically administered with low-dose prednisone or prednisolone to counteract the increase in corticosteroids produced by the body in response to decreased androgen levels.
• Regular Monitoring: Patients should undergo regular blood tests to monitor liver function, electrolyte levels, and blood pressure, as Abiraterone Acetate can affect these parameters.

Side Effects

Common Side Effects

• Fatigue: Many patients experience tiredness and lack of energy.
• Joint Pain: Arthralgia or joint pain is a frequently reported side effect.
• Hypertension: Increased blood pressure is a common occurrence due to the corticosteroid component.
• Edema: Swelling in the legs and feet can occur due to fluid retention.

Serious Side Effects

• Liver Toxicity: ABIRASTERON 250 can cause severe liver damage, necessitating regular liver function tests.
• Adrenal Insufficiency: The medication can lead to adrenal insufficiency, a condition where the adrenal glands do not produce enough steroid hormones.
• Cardiovascular Issues: Patients may experience heart problems, including arrhythmias and heart failure.

Precautions and Warnings

Contraindications

• Allergy to Abiraterone: Patients with a known allergy to Abiraterone Acetate should not take this medication.
• Severe Liver Impairment: ABIRASTERON 250 is contraindicated in patients with severe liver impairment due to the risk of hepatotoxicity.

Precautions

• Pregnancy: ABIRASTERON 250 is not intended for use in women and can cause harm to an unborn baby if taken during pregnancy.
• Concurrent Medications: Patients should inform their healthcare provider about all medications they are taking, as ABIRASTERON 250 can interact with other drugs.

Drug Interactions

Medications to Avoid

• CYP3A4 Inhibitors: Co-administration with CYP3A4 inhibitors (e.g., ketoconazole, itraconazole) can increase the plasma concentration of Abiraterone.
• CYP2D6 Substrates: ABIRASTERON 250 can increase the effects of CYP2D6 substrates (e.g., dextromethorphan, metoprolol).

Monitoring Required

• Blood Pressure Medications: Close monitoring is required for patients on antihypertensive medications due to the potential for increased blood pressure.

Patient Management

Lifestyle Modifications

• Dietary Considerations: Patients should adhere to dietary restrictions, taking ABIRASTERON 250 on an empty stomach.
• Exercise: Regular physical activity can help manage fatigue and improve overall well-being.

Regular Follow-Ups

• Liver Function Tests: Frequent liver function tests are essential to detect any signs of hepatotoxicity early.
• Blood Pressure Monitoring: Regular monitoring of blood pressure is crucial to manage hypertension effectively.

Conclusion

ABIRASTERON 250 is a valuable medication in the fight against advanced prostate cancer, offering hope to many patients. Its efficacy in reducing androgen levels and slowing the progression of cancer makes it a crucial component of prostate cancer therapy. However, it is essential to follow the prescribed dosage and administration guidelines, be aware of potential side effects, and maintain regular communication with healthcare providers to ensure optimal treatment outcomes. Steris Healthcare Pvt Ltd, founded by a group of expert professionals in the pharmaceutical industry in February 2018, operates as Sterispharma. This company, which is based in Navi Mumbai, holds certifications from WHO, GMP, and ISO. Its commitment is to provide high-quality drugs at affordable prices to its customers throughout India, following the rigorous guidelines set by the WHO. Steris offers the convenience of an online pharmacy where customers can easily buy medicines and enjoy the benefit of home delivery. At Steris, the mission is to supply a wide array of healthcare products designed to meet the varied needs of the medical community. Whether it is advanced treatments, medications for rare conditions, or basic health necessities, Sterispharma strives to serve the healthcare industry’s broad demands. The extensive product lineup from Steris includes treatments for various health areas such as Cardiology, Asthma, Respiratory issues, Nasal conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental care, and Dermatology.

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