AMBRISTAR 5 + DURA 20 Combo : The Ultimate Combo for Pulmonary Arterial Hypertension

Pulmonary Arterial Hypertension (PAH) is a progressive and serious condition that affects the lungs and the heart, making it harder for the heart to pump blood through the lungs. PAH can lead to severe symptoms such as shortness of breath, fatigue, dizziness, and chest pain. Managing this condition requires the right combination of medications that can improve the quality of life and slow disease progression. One such promising combination is AMBRISTAR 5 + DURA 20, a potent combo offer for PAH patients, containing Ambrisentan (5mg) and Tadalafil (20mg).

What is AMBRISTAR 5 + DURA 20?

AMBRISTAR 5 + DURA 20 is a fixed-dose combination therapy that combines two powerful medications, Ambrisentan and Tadalafil. Each tablet in the combo contains:

1. Ambrisentan (5mg) – An endothelin receptor antagonist (ERA).
2. Tadalafil (20mg) – A phosphodiesterase-5 (PDE-5) inhibitor.

This combination works synergistically to reduce pulmonary artery pressure, improve exercise capacity, and provide relief from symptoms in patients suffering from PAH.

Ambrisentan (5mg)

Ambrisentan belongs to a class of medications known as endothelin receptor antagonists (ERAs). Endothelin-1 is a potent vasoconstrictor that constricts blood vessels, increasing blood pressure. In PAH, high endothelin-1 levels can contribute to the narrowing of pulmonary arteries, which increases pulmonary arterial pressure and makes it difficult for the heart to pump blood through the lungs.

Ambrisentan works by selectively blocking the endothelin-1 receptors, ETA and ETB, in the smooth muscle of the pulmonary arteries. By doing so, it helps relax and dilate the blood vessels, ultimately reducing pulmonary pressure and improving blood flow to the lungs. This mechanism helps ease the symptoms of PAH, improving exercise tolerance and enhancing overall well-being.

Tadalafil (20mg)

Tadalafil, a member of the PDE-5 inhibitor class, is widely known for its ability to improve erectile dysfunction, but it also plays a significant role in managing PAH. PDE-5 enzymes break down cyclic guanosine monophosphate (cGMP), a molecule that helps regulate smooth muscle relaxation. In PAH, PDE-5 activity is elevated, contributing to reduced vasodilation in the pulmonary arteries.

Tadalafil works by inhibiting the PDE-5 enzyme, leading to increased levels of cGMP. This results in the relaxation of pulmonary artery smooth muscles, which dilates the vessels, reduces pulmonary arterial pressure, and improves oxygenation. Tadalafil also contributes to the enhanced exercise capacity and reduced symptoms, like breathlessness, that are associated with PAH.

Synergistic Effect of AMBRISTAR 5 + DURA 20

When used together in the AMBRISTAR 5 + DURA 20 combo, Ambrisentan and Tadalafil target two different pathways involved in pulmonary artery constriction, leading to a more comprehensive effect on pulmonary pressure reduction. The combination therapy provides synergistic benefits, which include:

• Enhanced Vasodilation: Both Ambrisentan and Tadalafil work to relax the pulmonary arteries, thereby reducing the pressure in the lungs and improving overall blood flow.

• Improved Exercise Capacity: By lowering pulmonary arterial pressure and improving oxygen delivery, patients typically experience an improvement in exercise tolerance, which is crucial for daily activities.

• Better Quality of Life: Reduced symptoms such as shortness of breath, fatigue, and chest pain can significantly improve the patient's overall well-being.

Indications and Benefits

AMBRISTAR 5 + DURA 20 is prescribed for the management of Pulmonary Arterial Hypertension (PAH), classified as WHO Group I. It is effective for:

1. Improving Exercise Capacity: The combination helps patients increase their functional ability by improving the circulation of blood through the lungs.
2. Relieving Symptoms of PAH: It effectively reduces the shortness of breath, fatigue, and chest discomfort associated with PAH.
3. Preventing Disease Progression: Both Ambrisentan and Tadalafil help slow down the progression of PAH by targeting different mechanisms of the disease.

Usage and Dosage

The recommended dose of AMBRISTAR 5 + DURA 20 is one tablet per day. It is essential to follow the doctor’s advice for the right dosage based on the individual’s response and condition. The combination is taken orally, and the treatment may be continued long-term to manage PAH.

Safety and Side Effects

As with any medication, AMBRISTAR 5 + DURA 20 may cause some side effects, though they are generally mild. Common side effects of Ambrisentan include headache, swelling, and dizziness, while Tadalafil may cause headaches, flushing, and nasal congestion.

Serious side effects are rare but may include:

• Liver issues: Both Ambrisentan and Tadalafil can affect liver function.
• Vision problems: Rare instances of vision disturbances have been reported.
• Low blood pressure: Because both drugs promote vasodilation, a slight reduction in blood pressure may occur, especially in patients already on antihypertensive treatment.

Patients should inform their healthcare provider about any existing conditions, particularly liver or kidney problems, heart issues, or low blood pressure.

Conclusion

AMBRISTAR 5 + DURA 20 provides an advanced and effective therapy for managing Pulmonary Arterial Hypertension. By combining Ambrisentan (5mg) and Tadalafil (20mg), the combination ensures that the patient benefits from two mechanisms of action that target the underlying causes of PAH. This combination has shown significant improvements in exercise capacity, symptom relief, and overall quality of life. Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options. The company offers a wide range of healthcare products, catering to various medical needs, from rare disease treatments to essential healthcare products. Sterispharma's product range includes solutions for Cardiology, Asthma, Respiratory Issues, Nasal Conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/Antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental Care, and Dermatology. Medicines can be conveniently ordered via Our websites—Sterisonline, Sterisindia, and Sterispharma.

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