Bosentan (125mg)

Introduction – Bosentan 125

Bosentan 125 is a prescription-based oral medication used for the treatment of Pulmonary Arterial Hypertension (PAH). It belongs to the class of endothelin receptor antagonists (ERAs) and works by blocking the action of endothelin-1 — a substance that causes the blood vessels in the lungs to constrict, leading to high blood pressure.

Formulated in the brand BOSENTIME 125 by Steris Healthcare Pvt Ltd, bosentan 125 offers effective relief from the symptoms of PAH, improves exercise tolerance, and helps reduce disease progression. It is widely used in adult patients as part of long-term therapy for managing PAH and improving quality of life.

Composition of BOSENTIME 125

• Active Ingredient: Bosentan

• Strength: 125 mg per tablet

• Dosage Form: Film-coated oral tablet

• Route of Administration: Oral

• Manufacturer: Steris Healthcare Pvt Ltd (WHO-GMP Certified)

Bosentan 125 Uses

The bosentan 125 tablet is used mainly in:

Pulmonary Arterial Hypertension (PAH)

• Improves ability to exercise

• Decreases symptoms such as shortness of breath and fatigue

• Slows down disease progression

• Suitable for idiopathic, heritable, or connective tissue disease-associated PAH

Digital Ulcers in Systemic Sclerosis (Off-Label Use)

• Helps prevent recurrence of painful finger ulcers caused by poor blood flow

 Always use bosentan 125 under the supervision of a qualified medical professional, especially due to its liver toxicity and pregnancy risks.

Bosentan Mechanism of Action

Bosentan acts as a dual endothelin receptor antagonist (blocks both ETA and ETB receptors). Endothelin-1 is a potent vasoconstrictor that narrows blood vessels and increases pulmonary pressure.

By blocking endothelin receptors, bosentan:

• Promotes vasodilation (widening of pulmonary arteries)

• Reduces pulmonary vascular resistance

• Enhances oxygen flow and heart function

• Provides symptomatic relief and long-term disease control

Bosentan Dose and Administration

Adults:

• Initial Therapy: Bosentan 62.5 mg twice daily for 4 weeks

• Maintenance Dose: Bosentan 125 mg twice daily (as in BOSENTIME 125)

Administration Tips:

• Can be taken with or without food

• Should be swallowed whole, not crushed or chewed

• Monthly liver function monitoring is recommended

Bosentan Side Effects

While bosentan 125 is generally well-tolerated, some side effects may occur:

Common Side Effects:

• Headache

• Flushing

• Leg/ankle swelling

• Nasal congestion

• Fatigue

Serious/Rare Side Effects:

• Liver damage (elevated liver enzymes)

• Anemia

• Low sperm count in males (reversible)

• Teratogenicity – not safe in pregnancy

 Regular blood tests are advised to monitor liver and hemoglobin levels during therapy.

Drug Interactions

Bosentan 125 may interact with:

• Cyclosporine A (contraindicated)

• Ketoconazole, rifampicin (may alter plasma levels)

• Oral contraceptives (effectiveness may reduce)

• Other PAH medications (e.g., sildenafil – monitor closely)

Bosentan Structure & Pharmacology

• Chemical Formula: C₂₇H₂₉N₅O₆S

• Molecular Weight: 551.6 g/mol

• Bioavailability: ~50%

• Half-life: ~5 hours

• Metabolism: Via CYP3A4 and CYP2C9 enzymes

• Excretion: Primarily through bile; minimal renal elimination

Bosentan 125 Uses in Hindi (बोसेंटन 125 टैबलेट के उपयोग)

बोसेंटन 125 टैबलेट का उपयोग फेफड़ों की उच्च रक्तचाप (PAH) की स्थिति में किया जाता है, जिससे फेफड़ों की धमनियों में रक्त का प्रवाह बेहतर होता है और सांस लेने में आसानी होती है। यह दवा रोग की प्रगति को धीमा करने और थकान को कम करने में मदद करती है।

Bosentan 125 Price in India

BOSENTIME 125, with its high-quality formulation, is competitively priced to ensure accessibility for patients needing long-term PAH treatment.

FAQs – Bosentan 125

Q1. What is bosentan 125 used for?

A: It is used to treat pulmonary arterial hypertension and improve exercise capacity in adult patients.

Q2. Is bosentan 125 safe in pregnancy?

A: No. Bosentan is harmful to the fetus and is contraindicated during pregnancy.

Q3. Can bosentan be taken long-term?

A: Yes, it is prescribed for long-term use, with regular monitoring.

Q4. What is the difference between bosentan 62.5 and 125?

A: Bosentan 62.5 mg is typically the starting dose; bosentan 125 mg is used for maintenance therapy.

Q5. How quickly does bosentan 125 work?

A: Clinical improvements are often seen within a few weeks, with continued benefits over months of use.

Why Choose Steris Healthcare Pvt Ltd?

Steris Healthcare Pvt Ltd is a trusted Indian pharmaceutical company known for delivering WHO-GMP certified, affordable, and high-quality medications. With a commitment to innovation and ethical practices, Steris Healthcare is redefining how healthcare is delivered in India.

Here's why Steris stands out:

•  WHO-GMP certified manufacturing excellence

•  Scientifically formulated, DCGI-approved molecules

•  A wide range of therapeutic segments: cardiology, pulmonology, diabetology, and dermatology

•  Strong PCD pharma franchise support across India

•  Transparent pricing, timely delivery, and personalized service

Whether you are a healthcare provider, distributor, or patient — Steris Healthcare delivers more than just medicine — we deliver trust.

Conclusion

BOSENTIME 125 offers a clinically proven solution for managing pulmonary arterial hypertension, improving heart-lung function, and enhancing quality of life. Powered by bosentan 125, it combines efficacy, safety, and trust. Manufactured by Steris Healthcare Pvt Ltd, BOSENTIME 125 ensures that every tablet meets global standards — because your health deserves the best.