BOSENTIME 125: Comprehensive Guide to Bosentan (125mg) Uses & Dosage

BOSENTIME 125 

 Bosentan (125mg)

Understanding Bosentan (125mg)

BOSENTIME 125 is a medication primarily used in the management of pulmonary arterial hypertension (PAH). It works as an endothelin receptor antagonist, helping to improve exercise capacity and delay clinical worsening in patients. This article delves into the uses, dosage, side effects, and additional important information about Bosentan (125mg).

Uses of Bosentan (125mg)

Bosentan (125mg) is prescribed for:

• Pulmonary Arterial Hypertension (PAH): It helps reduce blood pressure in the lungs, improving the ability to exercise and slowing the progression of symptoms.
• Systemic Sclerosis: Bosentan is also used off-label for the treatment of digital ulcers in patients with systemic sclerosis.

How Bosentan (125mg) Works

• Endothelin Receptor Antagonism: Bosentan blocks endothelin-1 receptors, which are responsible for blood vessel constriction. By inhibiting these receptors, Bosentan causes blood vessels to dilate, reducing pulmonary blood pressure.
• Improved Blood Flow: This dilation leads to improved blood flow and oxygen delivery throughout the body, which is crucial for PAH patients.

Dosage and Administration

• Starting Dose: The initial recommended dose is 62.5mg twice daily for the first 4 weeks.
• Maintenance Dose: After 4 weeks, the dose is usually increased to 125mg twice daily.
• Administration: It should be taken with or without food, consistently at the same times each day.

Potential Side Effects of Bosentan (125mg)

Common side effects may include:

• Headache: Mild to moderate headaches are commonly reported.
• Respiratory Tract Infections: Increased susceptibility to infections like colds and flu.
• Edema: Swelling in the ankles or feet due to fluid retention.
• Elevated Liver Enzymes: Regular liver function tests are recommended to monitor this potential side effect.

Precautions and Warnings

• Pregnancy: Bosentan can cause birth defects and is contraindicated in pregnancy. Effective contraception must be used during treatment.
• Liver Function: Regular monitoring of liver function is essential due to the risk of liver damage.
• Hemoglobin Levels: Periodic blood tests are necessary to check for anemia.

Drug Interactions

• Cyclosporine: Concurrent use with cyclosporine can increase Bosentan levels, potentially leading to toxicity.
• Rifampin: This antibiotic can reduce Bosentan's effectiveness by increasing its metabolism.

Conclusion

Bosentan (125mg), marketed under BOSENTIME 125, is a significant advancement in the treatment of PAH. By understanding its uses, mechanisms, and potential side effects, patients and healthcare providers can better manage the condition and improve quality of life. Steris Healthcare Pvt Ltd, operating as Sterispharma since its founding by expert professionals in the pharmaceutical industry in February 2018, is based in Navi Mumbai. The company is certified by WHO, GMP, and ISO, emphasizing its commitment to quality and safety. Sterispharma focuses on providing high-quality drugs at affordable prices throughout India, adhering strictly to WHO guidelines. Offering the convenience of an online pharmacy, customers can easily purchase medicines with home delivery options available. Sterispharma's mission is to supply a broad range of healthcare products to meet the diverse needs of the medical community. From advanced treatments and medications for rare conditions to essential health necessities, Sterispharma aims to serve the extensive demands of the healthcare industry. You can order medicines from Sterispharma through their websites, Sterisonline and Sterispharma. Their extensive product lineup includes treatments for Cardiology, Asthma, Respiratory Issues, Nasal Conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/Antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental Care, and Dermatology. 

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