BOSENTIME 62.5:Uses & Side effects and Precuations,Benefits and more..

Bosentan 62.5

Introduction – Bosentan 62.5

Bosentan 62.5 is a prescription oral medication used in the management of pulmonary arterial hypertension (PAH), a serious condition characterized by high blood pressure in the arteries of the lungs. Belonging to the class of endothelin receptor antagonists, bosentan 62.5 works by blocking the effects of endothelin-1, a natural substance that causes blood vessels to narrow. By promoting vasodilation, it helps reduce pulmonary pressure, improve heart function, and enhance the ability to exercise. With its proven efficacy and safety profile, bosentan 62.5 plays a vital role in improving the quality of life for patients with PAH.

What is Bosentan 62.5?

Bosentan 62.5 is an oral endothelin receptor antagonist primarily used for the treatment of pulmonary arterial hypertension (PAH) – a condition where the blood pressure in the arteries of the lungs becomes abnormally high. It works by blocking the action of endothelin-1, a natural substance that causes blood vessels to constrict and elevate pressure.

BOSENTIME 62.5, formulated with bosentan 62.5 mg, offers reliable control of PAH symptoms and improves exercise capacity, heart function, and overall quality of life in affected patients.

Composition of BOSENTIME 62.5

• Active Ingredient: Bosentan

• Strength: 62.5 mg

• Form: Film-coated oral tablet

• Route of Administration: Oral

Bosentan belongs to the dual endothelin receptor antagonist category, meaning it blocks both ETA and ETB receptors, providing a broader therapeutic effect.

Bosentan 62.5 Uses

Pulmonary Arterial Hypertension (PAH)

• Treatment of WHO Group I PAH in adults and children over 12 years

• Improves exercise capacity and delays disease progression

• Effective in idiopathic, heritable, or associated forms of PAH (e.g., connective tissue disease)

Prevention of Digital Ulcers

• Used off-label in systemic sclerosis patients to reduce recurrence of painful digital ulcers caused by poor blood flow

Note: Use must be under specialist supervision due to potential liver and fetal toxicity.

Bosentan 62.5 Uses in Hindi (बोसेंटन 62.5 टैबलेट के उपयोग)

बोसेंटन 62.5 टैबलेट का उपयोग पल्मोनरी आर्टेरियल हाइपरटेंशन (PAH) नामक बीमारी के इलाज में किया जाता है, जिसमें फेफड़ों की धमनियों में उच्च रक्तचाप होता है। यह दवा रक्त वाहिकाओं को फैलाकर रक्त प्रवाह को बेहतर बनाती है और दिल पर दबाव को कम करती है।

Bosentan Mechanism of Action

Bosentan 62.5 works by antagonizing endothelin-1, a potent vasoconstrictor that narrows pulmonary arteries. It blocks both ETA and ETB receptors, leading to:

• Vasodilation of pulmonary arteries

• Decreased pulmonary vascular resistance

• Improved cardiac output

• Delayed disease progression

This dual-action sets bosentan apart from selective receptor antagonists, offering a more comprehensive control over endothelin-mediated effects.

Bosentan Dose & Administration

Adults:

• Initial Dose: Bosentan 62.5 mg twice daily for 4 weeks

• Maintenance Dose: Bosentan 125 mg twice daily thereafter (as per physician’s decision)

 Pediatric Use:

• Carefully adjusted based on body weight and under close supervision

 Important: Dosage adjustments may be required in liver impairment or when used with other PAH medications.

Pharmacokinetics of Bosentan

• Bioavailability: ~50%

• Metabolism: Primarily by CYP3A4 and CYP2C9

• Elimination Half-life: ~5 hours

• Excretion: Mostly via bile, minimal via urine

Side Effects of Bosentan 62.5

Though generally well-tolerated, bosentan 62.5 may cause side effects that require monitoring:

Common Side Effects:

• Headache

• Flushing

• Edema (especially in ankles and feet)

• Respiratory tract infections

• Fatigue

Serious/Rare:

• Liver toxicity (elevated liver enzymes – requires monthly monitoring)

• Anemia

• Teratogenicity (harmful to fetus – contraindicated in pregnancy)

• Low sperm count in men (reversible)

Contraindications

• Pregnancy (Category X)

• Severe hepatic impairment

• Use with cyclosporine A or glyburide

• Known hypersensitivity to bosentan or formulation ingredients

Drug Interactions

• CYP3A4 and CYP2C9 inducers/inhibitors can alter bosentan levels

• May reduce the efficacy of oral contraceptives

• Caution with tacrolimus, rifampin, and ketoconazole

Liver function and hemoglobin levels must be regularly monitored during treatment.

Bosentan Structure (Chemical Info)

• Molecular Formula: C27H29N5O6S

• Molecular Weight: 551.6 g/mol

• Structure: Bipyrimidine sulfonamide derivative

![Optional: Structural image or link to reference]

Bosentan 62.5 Tablet Price in India

Bosentan 62.5 price in India varies depending on brand and packaging. BOSENTIME 62.5 is priced affordably to ensure broader patient access without compromising on quality.

Why Choose Steris Healthcare Pvt Ltd?

Steris Healthcare Pvt Ltd is a trusted name in the Indian pharmaceutical industry, known for its commitment to quality, innovation, and ethical business practices. With WHO-GMP certified manufacturing, we ensure that every product meets global standards for safety and efficacy. Our diverse portfolio covers pharmaceuticals, nutraceuticals, and personal care, including advanced skincare under the Eurosoft brand.

What sets us apart:

• ✅ High-quality formulations at affordable prices

• ✅ Pan-India distribution network & fast delivery

• ✅ Strong support for PCD franchise partners

• ✅ Transparent, customer-focused service

• ✅ Continuous innovation with DCGI-approved molecules

Whether you're a healthcare provider, distributor, or patient, Steris Healthcare stands for reliability, responsibility, and results. We don’t just make medicine — we deliver trust.

FAQs – Bosentan 62.5

Q1. What is bosentan 62.5 used for?

A: It is used to treat pulmonary arterial hypertension and reduce the frequency of digital ulcers in systemic sclerosis.

Q2. Is bosentan safe in pregnancy?

A: No. Bosentan is contraindicated in pregnancy due to high risk of fetal harm.

Q3. How long does bosentan take to show results?

A: Improvements in symptoms may be seen within 4–8 weeks, but long-term use is essential for sustained benefits.

Q4. Can bosentan be taken with food?

A: Yes, bosentan 62.5 can be taken with or without food.

Q5. Does bosentan affect liver function?

A: Yes, it may elevate liver enzymes. Regular liver monitoring is necessary.

Conclusion: Why Choose BOSENTIME 62.5?

BOSENTIME 62.5, containing bosentan 62.5, is a trusted formulation that plays a vital role in the management of pulmonary arterial hypertension, improving exercise tolerance, reducing symptoms, and enhancing patient quality of life. With WHO-GMP certified quality, affordable pricing, and superior clinical outcomes, BOSENTIME 62.5 by Steris Healthcare is your reliable choice in PAH care.