CILOSTAZONE 100 & Tablet - Steris Healthcare PVT LTD………

CILOSTAZONE 100

Cilostazol (100mg)

CILOSTAZONE 100 is a pharmaceutical product containing Cilostazol at a dosage of 100mg. Cilostazol is a medication primarily used to treat intermittent claudication, a condition characterized by pain and cramping in the legs due to inadequate blood flow during exercise. This article provides an in-depth look at Cilostazol, its uses, benefits, mechanisms, side effects, and important considerations for users.

What is Cilostazol?

Cilostazol is a quinolinone derivative that acts as a phosphodiesterase III inhibitor. It is an antiplatelet agent with vasodilatory properties, making it effective in managing conditions associated with poor blood circulation. By inhibiting phosphodiesterase III, Cilostazol increases cyclic adenosine monophosphate (cAMP) levels, leading to vasodilation and inhibition of platelet aggregation.

Uses of CILOSTAZONE 100

Intermittent Claudication

Cilostazol is primarily prescribed for the treatment of intermittent claudication. This condition is often a symptom of peripheral artery disease (PAD), where narrowed arteries reduce blood flow to the limbs, causing pain during physical activity.

Secondary Prevention of Stroke

In some cases, Cilostazol is used for the secondary prevention of stroke, particularly in patients who have experienced an ischemic stroke. Its antiplatelet properties help prevent the formation of new blood clots.

Peripheral Artery Disease

Patients with peripheral artery disease (PAD) may benefit from Cilostazol's ability to improve walking distance and alleviate symptoms associated with reduced blood flow to the limbs.

Mechanism of Action

Cilostazol works through several mechanisms:

1. Phosphodiesterase III Inhibition: By inhibiting this enzyme, Cilostazol increases cAMP levels in platelets and vascular smooth muscle cells. Elevated cAMP leads to reduced platelet aggregation and vasodilation.
2. Antiplatelet Effect: Cilostazol prevents platelets from clumping together, reducing the risk of blood clot formation.
3. Vasodilation: It relaxes blood vessels, improving blood flow and reducing symptoms of intermittent claudication.

Dosage and Administration

Standard Dosage

The standard dosage of CILOSTAZONE 100 is one 100mg tablet taken twice daily. It is recommended to take the medication 30 minutes before or two hours after breakfast and dinner to enhance absorption.

Adjustments

Dosage adjustments may be necessary for patients with liver or kidney impairment. It is crucial to follow the healthcare provider's instructions and not to adjust the dosage without medical advice.

Benefits of CILOSTAZONE 100

Improved Walking Distance

Patients with intermittent claudication often experience significant improvement in their walking distance and overall mobility when taking Cilostazol.

Reduced Pain and Discomfort

By enhancing blood flow to the limbs, Cilostazol helps reduce pain and discomfort associated with PAD and intermittent claudication.

Prevention of Blood Clots

Cilostazol's antiplatelet properties reduce the risk of blood clot formation, providing additional cardiovascular benefits.

Side Effects

Common Side Effects

• Headache
• Diarrhea
• Dizziness
• Palpitations

Serious Side Effects

• Increased risk of bleeding
• Tachycardia (rapid heartbeat)
• Hypotension (low blood pressure)
• Heart failure (rare)

Patients experiencing serious side effects should seek medical attention immediately.

Contraindications

Heart Failure

Cilostazol is contraindicated in patients with heart failure due to the risk of worsening the condition.

Hemorrhagic Disorders

Patients with bleeding disorders or those taking anticoagulants should avoid Cilostazol due to the increased risk of bleeding.

Hypersensitivity

Individuals with a known allergy to Cilostazol or any of its components should not use CILOSTAZONE 100.

Interactions

Drug Interactions

Cilostazol can interact with several medications, including:

• Anticoagulants (e.g., warfarin)
• Antiplatelet drugs (e.g., aspirin, clopidogrel)
• Certain antibiotics (e.g., erythromycin)
• Antifungal medications (e.g., ketoconazole)

Food Interactions

Taking Cilostazol with high-fat meals can increase its absorption, leading to higher plasma concentrations. It is recommended to take the medication on an empty stomach.

Special Considerations

Pregnancy and Breastfeeding

The safety of Cilostazol during pregnancy and breastfeeding is not well-established. Pregnant or breastfeeding women should consult their healthcare provider before using CILOSTAZONE 100.

Elderly Patients

Elderly patients may be more susceptible to the side effects of Cilostazol and may require dosage adjustments.

Monitoring

Patients taking Cilostazol should have regular follow-ups with their healthcare provider to monitor for side effects and assess the medication's effectiveness.

Conclusion

CILOSTAZONE 100, containing 100mg of Cilostazol, is an effective treatment for intermittent claudication and peripheral artery disease. Its ability to improve blood flow and reduce platelet aggregation makes it a valuable option for patients suffering from these conditions. However, it is essential to use the medication under medical supervision due to the potential for serious side effects and interactions. Always consult a healthcare provider before starting or adjusting the dosage of Cilostazol.  Steris Healthcare Pvt Ltd, founded by a group of expert professionals in the pharmaceutical industry in February 2018, operates as Sterispharma. This company, which is based in Navi Mumbai, holds certifications from WHO, GMP, and ISO. Its commitment is to provide high-quality drugs at affordable prices to its customers throughout India, following the rigorous guidelines set by the WHO. Steris offers the convenience of an online pharmacy where customers can easily buy medicines and enjoy the benefit of home delivery. At Steris, the mission is to supply a wide array of healthcare products designed to meet the varied needs of the medical community. Whether it is advanced treatments, medications for rare conditions, or basic health necessities, Sterispharma strives to serve the healthcare industry’s broad demands. The extensive product lineup from Steris includes treatments for various health areas such as Cardiology, Asthma, Respiratory issues, Nasal conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental care, and Dermatology.

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