CILOSTAZONE 50

CILOSTAZONE 50

Cilostazol (50mg)

CILOSTAZONE 50, containing the active ingredient Cilostazol (50mg), is a medication primarily used to treat intermittent claudication, a condition characterized by muscle pain due to inadequate blood flow, typically in the legs. This detailed article will explore various aspects of CILOSTAZONE 50, including its uses, benefits, mechanism of action, dosage, side effects, and more.

Understanding Intermittent Claudication

What is Intermittent Claudication?

Intermittent claudication is a symptom of peripheral arterial disease (PAD), which results from narrowed arteries and reduced blood flow to the limbs. This condition leads to pain, cramping, and fatigue in the muscles, particularly during exercise. CILOSTAZONE 50 is designed to alleviate these symptoms and improve the quality of life for individuals suffering from intermittent claudication.

Causes and Risk Factors

The primary cause of intermittent claudication is atherosclerosis, a condition where fatty deposits build up in the arteries, leading to reduced blood flow. Risk factors for atherosclerosis and PAD include:

• Smoking
• Diabetes
• High blood pressure
• High cholesterol
• Obesity
• Sedentary lifestyle

Symptoms of Intermittent Claudication

Common symptoms of intermittent claudication include:

• Pain or cramping in the legs, thighs, or buttocks during physical activity
• Numbness or weakness in the legs
• Coldness in the lower leg or foot
• Sores on the toes, feet, or legs that won't heal

What is Cilostazol?

Overview

Cilostazol is a medication that belongs to the class of phosphodiesterase III inhibitors. It works by inhibiting the enzyme phosphodiesterase type III, leading to increased levels of cyclic adenosine monophosphate (cAMP). This results in vasodilation (widening of blood vessels) and inhibition of platelet aggregation, thereby improving blood flow and reducing pain associated with intermittent claudication.

Pharmacokinetics

• Absorption: Cilostazol is rapidly absorbed after oral administration. Peak plasma concentrations are typically reached within 2-4 hours.
• Distribution: It is extensively bound to plasma proteins, mainly albumin.
• Metabolism: Cilostazol is metabolized in the liver by the cytochrome P450 enzymes, primarily CYP3A4 and CYP2C19.
• Elimination: The drug and its metabolites are primarily excreted in the urine, with a half-life of approximately 11-13 hours.

Uses of CILOSTAZONE 50

Primary Indication

The main use of CILOSTAZONE 50 is the treatment of intermittent claudication. By improving blood flow to the limbs, Cilostazol helps to reduce pain and increase the walking distance for individuals affected by this condition.

Off-Label Uses

While the primary indication for Cilostazol is intermittent claudication, it may also be used off-label for other conditions, such as:

• Prevention of stroke in patients with a history of ischemic stroke
• Secondary prevention of coronary artery disease
• Treatment of chronic arterial occlusion

Dosage and Administration

Recommended Dosage

The usual recommended dosage of CILOSTAZONE 50 is 100mg taken twice daily. However, for individuals who may experience side effects or require a lower dosage, CILOSTAZONE 50 (50mg twice daily) can be an alternative option. It is important to take the medication at least 30 minutes before or 2 hours after breakfast and dinner to enhance absorption.

Dosage Adjustments

Dosage adjustments may be necessary for certain populations, including:

• Elderly Patients: Due to potential alterations in drug metabolism and excretion.
• Patients with Hepatic Impairment: Cilostazol is metabolized in the liver, so caution is advised.
• Patients with Renal Impairment: Dosage adjustments may be required based on the severity of renal impairment.

Missed Dose

If a dose is missed, it should be taken as soon as remembered unless it is almost time for the next dose. In such cases, skip the missed dose and resume the regular dosing schedule. Do not double the dose to catch up.

Side Effects of CILOSTAZONE 50

Common Side Effects

Some common side effects associated with CILOSTAZONE 50 include:

• Headache
• Diarrhea
• Abnormal stools
• Dizziness
• Palpitations

Serious Side Effects

While rare, serious side effects can occur, such as:

• Severe allergic reactions (rash, itching, swelling, severe dizziness, trouble breathing)
• Rapid or irregular heartbeat
• Signs of bleeding (unusual bruising, black/tarry stools, blood in urine)

Managing Side Effects

Most side effects are mild and transient. However, if severe or persistent side effects occur, it is important to contact a healthcare provider. Supportive care and dosage adjustments may be necessary to manage adverse effects.

Drug Interactions

Medications

CILOSTAZONE 50 can interact with various medications, including:

• Anticoagulants and Antiplatelet Drugs: Increased risk of bleeding.
• Cytochrome P450 Inhibitors: Such as ketoconazole, erythromycin, and diltiazem, which can increase Cilostazol levels.
• Cytochrome P450 Inducers: Such as rifampin and phenytoin, which can decrease Cilostazol levels.

Food Interactions

Food can affect the absorption of Cilostazol. It is recommended to take CILOSTAZONE 50 on an empty stomach to enhance its bioavailability.

Alcohol

Alcohol consumption should be limited while taking CILOSTAZONE 50 as it can increase the risk of side effects and interfere with the medication's efficacy.

Precautions and Warnings

Contraindications

CILOSTAZONE 50 is contraindicated in patients with:

• Congestive heart failure
• Known hypersensitivity to Cilostazol or any of its components
• Active bleeding disorders

Special Populations

• Pregnancy and Lactation: Cilostazol should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether Cilostazol is excreted in human milk, so caution is advised.
• Pediatric Use: The safety and efficacy of Cilostazol in pediatric patients have not been established.
• Geriatric Use: Elderly patients may be more susceptible to side effects and may require dosage adjustments.

Monitoring

Regular monitoring is essential for patients on CILOSTAZONE 50. This includes:

• Blood Pressure: To detect any potential increases.
• Complete Blood Count (CBC): To monitor for signs of bleeding or other hematologic effects.
• Liver Function Tests: To assess for any potential hepatic impairment.

Benefits of CILOSTAZONE 50

Improved Walking Distance

Clinical studies have demonstrated that Cilostazol significantly improves walking distance in patients with intermittent claudication, allowing them to engage in more physical activities with reduced pain.

Enhanced Quality of Life

By alleviating the symptoms of intermittent claudication, CILOSTAZONE 50 enhances the overall quality of life, enabling patients to perform daily activities more comfortably.

Potential Cardiovascular Benefits

Cilostazol's antiplatelet and vasodilatory properties may offer additional cardiovascular benefits, such as reduced risk of stroke and improved coronary artery function, although more research is needed in these areas.

Conclusion

CILOSTAZONE 50 is a valuable medication for individuals suffering from intermittent claudication, offering significant improvements in walking distance and quality of life. With proper usage, monitoring, and management of side effects, Cilostazol can be an effective part of a comprehensive treatment plan for peripheral arterial disease.  Steris Healthcare Pvt Ltd, founded by a group of expert professionals in the pharmaceutical industry in February 2018, operates as Sterispharma. This company, which is based in Navi Mumbai, holds certifications from WHO, GMP, and ISO. Its commitment is to provide high-quality drugs at affordable prices to its customers throughout India, following the rigorous guidelines set by the WHO. Steris offers the convenience of an online pharmacy where customers can easily buy medicines and enjoy the benefit of home delivery. At Steris, the mission is to supply a wide array of healthcare products designed to meet the varied needs of the medical community. Whether it is advanced treatments, medications for rare conditions, or basic health necessities, Sterispharma strives to serve the healthcare industry’s broad demands. The extensive product lineup from Steris includes treatments for various health areas such as Cardiology, Asthma, Respiratory issues, Nasal conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental care, and Dermatology.

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