Dabigatran Etexilate & DABIGATREX 110 Mg : STERIS PHARMA

DABIGATREX 110 Mg

Dabigatran Etexilate (75mg)

DABIGATREX 110, containing Dabigatran Etexilate (75mg), is an anticoagulant medication used to prevent and treat various blood clot-related conditions. It belongs to a class of drugs known as direct thrombin inhibitors. This article provides an in-depth look into DABIGATREX 110, covering its uses, dosage, side effects, composition, and more, ensuring a comprehensive understanding of this medication.

Composition

DABIGATREX 110 contains:

• Dabigatran Etexilate: 75 mg

Mechanism of Action

Dabigatran Etexilate is a prodrug that, once ingested, is converted into its active form, Dabigatran. Dabigatran works by directly inhibiting thrombin, an enzyme essential for blood clot formation. By inhibiting thrombin, Dabigatran prevents the conversion of fibrinogen to fibrin, thereby reducing the formation of clots. This action helps in the prevention and treatment of thromboembolic events.

Uses

DABIGATREX 110 is prescribed for:

• Treatment and prevention of deep vein thrombosis (DVT) and pulmonary embolism (PE)
• Prophylaxis of DVT and PE in patients undergoing hip replacement surgery

Dosage and Administration

The dosage of DABIGATREX 110 should be individualized based on the patient's condition, renal function, and concomitant medications. Typically, the recommended dose is:

• Treatment of DVT and PE: 75 mg twice daily after initial treatment with a parenteral anticoagulant for 5-10 days
• Prophylaxis of DVT and PE following hip replacement surgery: 75 mg twice daily, starting with a single dose 1-4 hours after surgery and continuing for 28-35 days

How to Take DABIGATREX 110

• Swallow the capsule whole; do not crush, chew, or open it.
• Maintain a consistent schedule to ensure stable blood anticoagulation levels.

Side Effects

Like any medication, DABIGATREX 110 may cause side effects. Common side effects include:

• Gastrointestinal disturbances (dyspepsia, gastritis, abdominal pain)
• Bleeding (bruising, nosebleeds, bleeding gums)
• Anemia
• Nausea

Serious but rare side effects may include:

• Severe bleeding (gastrointestinal bleeding, intracranial hemorrhage)
• Allergic reactions (rash, itching, swelling)
• Liver dysfunction (elevated liver enzymes)

Precautions and Warnings

• Renal Function: Monitor renal function before initiating treatment and periodically thereafter, as Dabigatran is primarily excreted by the kidneys.
• Bleeding Risk: Increased risk of bleeding, particularly in patients with renal impairment, advanced age, or those taking concomitant medications that affect hemostasis.
• Hypersensitivity: Avoid use in patients with a known hypersensitivity to Dabigatran or any component of the formulation.
• Surgery: Temporarily discontinue DABIGATREX 110 before elective surgery or invasive procedures to reduce the risk of bleeding.

Interactions

DABIGATREX 110 can interact with several medications, potentially altering their effects. Some notable interactions include:

• Anticoagulants and Antiplatelet Agents: Increases the risk of bleeding.
• P-glycoprotein Inhibitors: Can increase Dabigatran exposure and the risk of bleeding.

Monitoring

Regular monitoring is crucial to ensure the safe and effective use of DABIGATREX 110:

• Renal Function: Periodic assessment of kidney function is necessary.
• Hemoglobin and Hematocrit Levels: To detect potential bleeding.
• Signs of Bleeding: Monitor for any signs of unusual bleeding or bruising.

Lifestyle and Dietary Recommendations

• Diet: Maintain a balanced diet and avoid excessive alcohol consumption, as it can increase the risk of bleeding.
• Exercise: Engage in regular physical activity but avoid high-risk activities that could lead to injury or bleeding.
• Hydration: Ensure adequate fluid intake to support overall health.

Conclusion

DABIGATREX 110, containing Dabigatran Etexilate (75mg), is an effective anticoagulant for preventing and treating various thromboembolic conditions. Always consult with a healthcare provider for personalized advice and monitoring while using this medication. Steris Healthcare Pvt Ltd, established in February 2018 by seasoned professionals in the pharmaceutical sector, operates under the name Sterispharma. Headquartered in Navi Mumbai, the company is certified by WHO, GMP, and ISO. Sterispharma is dedicated to providing high-quality medications at affordable prices across India, adhering to stringent WHO guidelines. They offer an online pharmacy platform for easy medicine purchases and home delivery. The company's mission is to deliver a diverse range of healthcare products catering to the varied needs of the medical community. From advanced treatments and rare condition medications to essential health supplies, Sterispharma aims to meet the extensive demands of the healthcare industry. Their product range covers numerous health fields, including Cardiology, Asthma, Respiratory issues, Nasal conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental care, and Dermatology.

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