Dabigatran Etexilate & DABIGATREX 75 Mg : Uses, Benefits, Dosage, Price & Side Effects

DABIGATREX 75 Mg

Dabigatran Etexilate 75 mg

DABIGATREX 75 is a medication used to prevent blood clots and reduce the risk of stroke in patients with certain cardiovascular conditions. It contains Dabigatran Etexilate, a direct thrombin inhibitor, which helps in preventing clot formation. This article provides a detailed overview of DABIGATREX 75, covering its uses, dosage, side effects, composition, and more to ensure a thorough understanding of this medication.

Composition

DABIGATREX 75 contains:

• Dabigatran Etexilate: 75 mg

Mechanism of Action

Dabigatran Etexilate is a prodrug that, once ingested, is converted to its active form, Dabigatran. Dabigatran directly inhibits thrombin, an enzyme essential for blood clot formation. By blocking thrombin, Dabigatran prevents the conversion of fibrinogen to fibrin, thus inhibiting the final step in the coagulation cascade and reducing the formation of blood clots.

Uses

DABIGATREX 75 is prescribed for:

• Treatment and prevention of deep vein thrombosis (DVT)
• Treatment and prevention of pulmonary embolism (PE)
• Prevention of DVT and PE following hip replacement surgery

Dosage and Administration

The dosage of DABIGATREX 75 should be individualized based on the patient's condition, renal function, and risk of bleeding. The typical dosing guidelines are:

• Non-Valvular Atrial Fibrillation: 75 mg twice daily
• Treatment of DVT and PE: 75 mg twice daily after initial treatment with a parenteral anticoagulant for 5-10 days
• Prevention of DVT and PE following hip replacement surgery: 75 mg twice daily, starting 1-4 hours after surgery

How to Take DABIGATREX 75

• Swallow the capsule whole with a glass of water; do not crush, chew, or break it.
• Maintain a consistent schedule to ensure stable anticoagulant effect.

Side Effects

Like any medication, DABIGATREX 75 may cause side effects. Common side effects include:

• Gastrointestinal disturbances (dyspepsia, nausea, abdominal pain)
• Bleeding (bruising, nosebleeds, gastrointestinal bleeding)
• Anemia
• Fatigue

Serious but rare side effects may include:

• Major bleeding (intracranial hemorrhage, gastrointestinal hemorrhage)
• (rash, itching, swelling)
• Liver dysfunction (elevated liver enzymes)

Precautions and Warnings

• Renal Function: Monitor renal function regularly, as Dabigatran is primarily excreted by the kidneys.
• Bleeding Risk: Patients with an increased risk of bleeding, such as those with recent surgery, trauma, or active ulcers, should use Dabigatran with caution.
• Hypersensitivity: Avoid use in patients with known hypersensitivity to Dabigatran Etexilate or any component of the formulation.
• Liver Function: Use with caution in patients with liver impairment.

Interactions

DABIGATREX 75 can interact with several medications, potentially altering their effects. Some notable interactions include:

• Anticoagulants and Antiplatelet Agents: Increased risk of bleeding when combined with other anticoagulants or antiplatelet agents.
• Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Increased risk of gastrointestinal bleeding.
• P-glycoprotein Inhibitors: Drugs such as ketoconazole, amiodarone, and verapamil can increase Dabigatran levels and the risk of bleeding.

Monitoring

Regular monitoring is crucial to ensure the safe and effective use of DABIGATREX 75:

• Renal Function: Regular assessment of renal function is necessary, especially in elderly patients.
• Signs of Bleeding: Monitor for any signs of bleeding, such as unusual bruising or prolonged bleeding from cuts.
• Liver Function Tests: Periodic monitoring of liver enzymes is recommended.

Lifestyle and Dietary Recommendations

• Diet: There are no specific dietary restrictions with Dabigatran, but maintaining a balanced diet is beneficial for overall health.
• Hydration: Maintain adequate fluid intake to support overall health and medication efficacy.
• Alcohol: Limit alcohol consumption, as it can increase the risk of bleeding.

Conclusion

DABIGATREX 75, containing Dabigatran Etexilate, offers an effective solution for preventing blood clots and reducing the risk of stroke in patients with certain cardiovascular conditions. Always consult with a healthcare provider for personalized advice and monitoring while using this medication. Steris Healthcare Pvt Ltd, established in February 2018 by seasoned professionals in the pharmaceutical sector, operates under the name Sterispharma. Headquartered in Navi Mumbai, the company is certified by WHO, GMP, and ISO. Sterispharma is dedicated to providing high-quality medications at affordable prices across India, adhering to stringent WHO guidelines. They offer an online pharmacy platform for easy medicine purchases and home delivery. The company's mission is to deliver a diverse range of healthcare products catering to the varied needs of the medical community. From advanced treatments and rare condition medications to essential health supplies, Sterispharma aims to meet the extensive demands of the healthcare industry. Their product range covers numerous health fields, including Cardiology, Asthma, Respiratory issues, Nasal conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental care, and Dermatology.

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