Dapaflozin and Metformin

Introduction

GLIDAPAFLOZIN 5 contains Dapagliflozin (5mg), a sodium-glucose co-transporter-2 (SGLT2) inhibitor used for the management of type 2 diabetes mellitus. It works by reducing blood sugar levels through increased glucose excretion in urine. This medication is widely prescribed to improve glycemic control in adults and may also have additional cardiovascular and renal benefits.

Key Ingredients

• Dapagliflozin (5mg): A selective SGLT2 inhibitor that prevents glucose reabsorption in the kidneys, thereby lowering blood glucose levels.

How Does GLIDAPAFLOZIN 5 Work?

Dapagliflozin, the active component of GLIDAPAFLOZIN 5, works by blocking the SGLT2 protein in the kidneys, which is responsible for glucose reabsorption. This action leads to increased urinary glucose excretion (UGE), thereby reducing blood sugar levels.

Apart from glucose control, Dapagliflozin is known to promote weight loss, improve blood pressure, and provide cardiovascular and renal protection.

Uses of GLIDAPAFLOZIN 5

GLIDAPAFLOZIN 5 is primarily used for:

1. Managing Type 2 Diabetes Mellitus – Helps lower blood sugar levels when used alongside a proper diet and exercise regimen.

2. Reducing Cardiovascular Risks – Reduces the risk of heart failure and cardiovascular events in diabetic patients.

3. Chronic Kidney Disease (CKD) Management – Slows the progression of kidney damage in diabetes patients with CKD.

4. Weight Management – Aids in weight reduction by eliminating excess glucose from the body.

5. Blood Pressure Control – Helps lower blood pressure levels by promoting mild diuresis (fluid loss).

Dosage and Administration

• Recommended Dose: 5mg once daily, taken with or without food.

• Titration: Based on clinical response, the dose may be increased to 10mg daily.

• Renal Impairment: Patients with severe kidney disease should consult a doctor before using this medication.

• Missed Dose: Take as soon as possible, but avoid double dosing.

Who Should Take GLIDAPAFLOZIN 5?

This medication is prescribed for adults with Type 2 diabetes who:

• Have uncontrolled blood sugar levels despite diet and exercise.

• Need additional therapy alongside metformin, sulfonylureas, or insulin.

• Are at risk of cardiovascular diseases.

• Have chronic kidney disease requiring glucose control.

Who Should Not Take GLIDAPAFLOZIN 5?

This medication is not recommended for:

• Type 1 Diabetes patients.

• Individuals with severe kidney impairment.

• Pregnant or breastfeeding women.

• Those with a history of diabetic ketoacidosis (DKA).

Potential Side Effects

Like any medication, GLIDAPAFLOZIN 5 may have some side effects, including:

Common Side Effects:

• Increased urination.

• Urinary tract infections (UTIs).

• Yeast infections (especially in women).

• Mild dehydration or dizziness.

• Low blood pressure.

Rare but Serious Side Effects:

• Ketoacidosis – A serious condition where acid levels rise in the blood, requiring immediate medical attention.

• Severe dehydration – Can lead to electrolyte imbalance.

• Fournier’s Gangrene – A rare but severe genital infection.

• Kidney Function Decline – Usually reversible with proper monitoring.

Precautions and Warnings

• Monitor Kidney Function: Regular renal function tests are required before and during treatment.

• Hydration: Drink plenty of fluids to avoid dehydration.

• Infections: Maintain good personal hygiene to prevent urinary and genital infections.

• Alcohol Consumption: Avoid excessive alcohol as it may increase the risk of ketoacidosis.

• Blood Pressure Monitoring: Patients with low blood pressure should consult their doctor for dose adjustments.

Drug Interactions

GLIDAPAFLOZIN 5 may interact with:

• Diuretics – May increase the risk of dehydration and low blood pressure.

• Insulin or Sulfonylureas – May lead to hypoglycemia (low blood sugar levels).

• NSAIDs (e.g., ibuprofen, naproxen) – Can affect kidney function.

• Lithium – Increased excretion may reduce lithium levels in the body.

Lifestyle and Dietary Recommendations

• Follow a balanced diet rich in whole grains, vegetables, and lean proteins.

• Engage in regular physical activity to improve blood sugar control.

• Stay hydrated to prevent dehydration.

• Maintain good foot care to prevent diabetic complications.

Comparison with Other SGLT2 Inhibitors

Benefits of GLIDAPAFLOZIN 5

• Improves Glycemic Control – Reduces HbA1c levels effectively.
• Aids in Weight Loss – Helps eliminate excess glucose, promoting weight reduction.
• Cardiovascular Protection – Lowers the risk of heart failure and stroke.
• Supports Kidney Health – Delays renal disease progression.
• Convenient Dosing – Once-daily tablet for easy adherence.

Price and Availability

The price of GLIDAPAFLOZIN 5 varies by region, pharmacy, and manufacturer. In India, the estimated price range is ₹50–₹150 per tablet, depending on packaging and brand discounts.

Conclusion

GLIDAPAFLOZIN 5 (Dapagliflozin 5mg) is an effective and well-tolerated medication for managing Type 2 diabetes mellitus, with added benefits for cardiovascular and kidney health. It offers blood sugar control, weight loss, and cardiovascular protection in a single daily dose. However, proper hydration, regular monitoring, and lifestyle modifications are essential to maximize its benefits and minimize side effects. Always consult a healthcare professional before starting this medication to ensure its safety and effectiveness for your condition.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

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