Divalproex ER 250mg"'"''"''""

Divalproex ER (extended-release) 
DIOWELPREX ER

Diowelprex ER 250 is a medication primarily used to manage certain types of seizure disorders, bipolar disorder, and to prevent migraine headaches. The active ingredient in Diowelprex ER 250 is Divalproex Sodium (250 mg), which is an extended-release formulation of valproic acid. This extended-release version is beneficial in managing various conditions requiring stable plasma levels of the medication, enhancing the efficacy of treatment and improving patient compliance. This article provides a comprehensive look into the composition, uses, pharmacology, and potential benefits of Diowelprex ER 250, as well as precautions for its use.

Composition and Pharmacology of Diowelprex ER 250

1. Active Ingredient: Divalproex Sodium (250 mg)

The primary component of Diowelprex ER 250 is Divalproex Sodium, which delivers 250 mg of the active drug. Divalproex sodium is a compound that, when administered, dissociates to release valproate ions. These ions are absorbed into the bloodstream and work at the cellular level to stabilize mood and prevent seizure activity in the brain.

2. Mechanism of Action

Divalproex works through multiple mechanisms to prevent seizures, regulate mood swings, and reduce migraine occurrence:

• Increasing GABA Levels: Divalproex increases the levels of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the brain. GABA helps calm neuronal firing, which reduces seizure activity and can stabilize mood.
• Sodium Channel Blockade: The drug also affects sodium channels in neurons, slowing down the rapid firing of these channels during seizures, thus aiding in the prevention of seizures.
• Modulation of Calcium Channels: By regulating calcium influx in neurons, Divalproex helps stabilize neuronal activity, reducing episodes of mania and mood instability.

3. Extended-Release Formulation

The "ER" in Diowelprex ER stands for Extended-Release, meaning the medication is designed to release slowly over time. This allows for more stable blood levels, reducing the need for multiple doses and minimizing fluctuations in drug concentration, which can lead to side effects or suboptimal therapeutic effects.

Uses of Diowelprex ER 250

Diowelprex ER 250 is widely prescribed for several conditions:

1. Epilepsy and Seizure Disorders

   • Divalproex ER is commonly used as an anticonvulsant to treat various seizure types, including complex partial seizures, absence seizures, and generalized seizures.
   • For epilepsy patients, Divalproex helps reduce seizure frequency and severity, allowing for a more stable quality of life.

2. Bipolar Disorder and Mood Stabilization

   • Diowelprex ER 250 is frequently prescribed as a mood stabilizer in patients with bipolar disorder. It helps in controlling manic and hypomanic episodes, balancing mood swings, and preventing relapses.
   • By targeting neurotransmitters associated with mood regulation, Divalproex aids in reducing irritability, mood fluctuations, and other symptoms associated with bipolar disorder.

3. Migraine Prevention

   • Divalproex ER 250 has demonstrated efficacy in the prophylactic treatment of migraines. Although it does not relieve migraine pain, it can significantly reduce the frequency and intensity of migraine episodes over time, improving patient quality of life.

Benefits of Diowelprex ER 250

1. Improved Compliance and Stability

The extended-release formulation of Diowelprex ER 250 helps improve patient compliance by reducing the need for multiple doses throughout the day. This steady release of medication also provides consistent therapeutic levels, which minimizes the occurrence of breakthrough seizures, mood instability, and migraine episodes.

2. Well-Studied and Effective

Divalproex is one of the most widely studied medications for seizure control, mood stabilization, and migraine prevention. Its efficacy in these areas has been established through multiple clinical trials, making it a reliable treatment option for patients with these conditions.

3. Reduced Side Effects

By releasing the medication gradually, the ER formulation minimizes peaks and troughs in drug concentration that can lead to side effects like drowsiness, dizziness, and gastrointestinal upset. Patients on Diowelprex ER 250 may experience fewer side effects than those on immediate-release formulations.

Potential Side Effects

While Diowelprex ER 250 is generally well-tolerated, some patients may experience side effects. Common side effects may include:

• Gastrointestinal Issues: Such as nausea, vomiting, and abdominal pain.
• Drowsiness or Fatigue: Due to its central nervous system effects.
• Hair Loss: Temporary hair thinning or loss may occur in some patients.
• Tremors: Fine motor tremors are common in some individuals, especially at higher doses.

Less commonly, patients may experience serious side effects such as liver toxicity, pancreatitis, or significant changes in blood cell counts. Routine blood work is recommended to monitor liver function and overall health while taking Diowelprex ER 250, especially in long-term users.

Precautions and Contraindications

1. Liver Disease: Diowelprex ER 250 is contraindicated in patients with liver disease or significant hepatic dysfunction due to the risk of hepatotoxicity.
2. Pregnancy: This medication is generally not recommended for pregnant women, especially during the first trimester, as it may lead to congenital malformations. Women of childbearing potential should consult their doctor before starting treatment.
3. Pancreatitis: Divalproex sodium has been associated with cases of life-threatening pancreatitis. Patients with a history of this condition should use caution.
4. Allergic Reactions: Patients with hypersensitivity to valproic acid or any component of Diowelprex ER should avoid this medication.

Dosage and Administration

The typical starting dose for Diowelprex ER 250 is generally determined based on the condition being treated and individual patient factors such as age, weight, and other medications taken concurrently. However, a standard adult starting dose often involves taking 250 mg once or twice daily, which can be gradually increased based on clinical response and tolerance.

It's important for patients to take Diowelprex ER 250 at the same time each day, as this helps maintain consistent plasma levels. Additionally, patients are advised not to crush or chew the tablets, as this can interfere with the extended-release formulation.

Drug Interactions

Diowelprex ER 250 can interact with several other medications, including:

• Anticoagulants (e.g., warfarin): This combination may increase the risk of bleeding.
• Other Antiepileptic Drugs: Drugs such as carbamazepine or phenytoin may alter the efficacy of Diowelprex ER.
• Antidepressants and Antipsychotics: These can affect valproate metabolism, potentially altering the effectiveness of treatment.

Patients should inform their healthcare providers about all medications they are currently taking to avoid adverse interactions.

Monitoring and Follow-Up

Regular blood tests are necessary to monitor liver function, platelet count, and valproate blood levels during treatment with Diowelprex ER 250. Regular follow-ups help ensure safety and effectiveness, allowing for adjustments in dose if needed.

Conclusion

Diowelprex ER 250, with its active ingredient Divalproex Sodium 250 mg, serves as an effective option for the treatment of epilepsy, bipolar disorder, and migraine prevention. Its extended-release formulation enhances patient compliance and reduces the likelihood of fluctuations in drug levels, making it ideal for long-term management. However, patients should adhere to regular monitoring and consult their healthcare provider to ensure safe and effective use. Diowelprex ER 250, with proper use and precaution, has the potential to significantly improve the quality of life for individuals dealing with these complex conditions. Steris Healthcare Pvt Ltd, operating as Sterispharma since its founding by expert professionals in the pharmaceutical industry in February 2018, is based in Navi Mumbai. The company is certified by WHO, GMP, and ISO, emphasizing its commitment to quality and safety. Sterispharma focuses on providing high-quality drugs at affordable prices throughout India, adhering strictly to WHO guidelines. Offering the convenience of an online pharmacy, customers can easily purchase medicines with home delivery options available. Sterispharma's mission is to supply a broad range of healthcare products to meet the diverse needs of the medical community. From advanced treatments and medications for rare conditions to essential health necessities, Sterispharma aims to serve the extensive demands of the healthcare industry. You can order medicines from Sterispharma through their websites, Sterisonline  ,  Sterisindia and Sterispharma. Their extensive product lineup includes treatments for Cardiology, Asthma, Respiratory Issues, Nasal Conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/Antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental Care, and Dermatology. 

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