Epalrestat 150 mg (EPSTATE SR 150): Benefits, Risks, and Clinical Use

Introduction

EPSTATE SR 150 is a prescription medication containing Epalrestat 150 mg as its active ingredient. Epalrestat is classified as an aldose reductase inhibitor and is primarily used for the management of diabetic peripheral neuropathy, a common complication of long-standing diabetes.

Composition

Each sustained release tablet of EPSTATE SR 150 contains:

• Epalrestat – 150 mg

Excipients: As per formulation (may include binders, stabilizers, and coating agents)

Mechanism of Action

Epalrestat works by inhibiting the enzyme aldose reductase, which plays a role in the polyol pathway. In diabetic patients, excess glucose is converted into sorbitol via this pathway. Sorbitol accumulation in nerve cells leads to oxidative stress, cellular damage, and the development of neuropathy. By inhibiting aldose reductase, Epalrestat prevents this harmful process and protects nerve function.

Indications and Uses

EPSTATE SR 150 is indicated for the treatment of:

• Diabetic Peripheral Neuropathy (DPN)
  – Burning, tingling, or numbness in the feet and hands
  – Pain and hypersensitivity in extremities
  – Loss of reflexes and coordination

It may also help improve:

• Nerve conduction velocity

• Subjective symptoms like muscle cramps, fatigue, and cold sensations in limbs

Dosage and Administration

• Recommended Dose: One tablet (150 mg) once daily, preferably after meals.

• Route: Oral

• Form: Sustained release – provides prolonged drug action

Important: Dosage may vary based on patient condition and physician’s discretion. Always follow the doctor’s instructions.

Side Effects

Like all medications, Epalrestat may cause side effects, although not everyone experiences them.

Common Side Effects:

• Nausea

• Headache

• Gastrointestinal discomfort

• Skin rash

• Dizziness

Rare but Serious Side Effects:

• Elevated liver enzymes (hepatotoxicity)

• Hypersensitivity reactions

Report any unusual or persistent symptoms to a healthcare provider promptly.

Contraindications

Do not use EPSTATE SR 150 if:

• You are allergic to Epalrestat or any component of the tablet

• You have severe liver dysfunction

• You are pregnant or breastfeeding (unless advised by a doctor)

Precautions

• Liver function tests should be monitored during treatment.

• Use with caution in elderly patients.

• Not recommended for pediatric use unless specifically directed.

• Avoid alcohol consumption as it may worsen neuropathic symptoms.

Drug Interactions

While Epalrestat generally has a low risk of drug interactions, inform your healthcare provider if you are taking:

• Antidiabetic agents (risk of hypoglycemia)

• Antiepileptics

• Herbal supplements

Storage

• Store below 25°C in a dry place.

• Protect from light and moisture.

• Keep out of reach of children.

FAQs

1. What is EPSTATE SR 150 used for?

EPSTATE SR 150 is used to manage diabetic peripheral neuropathy by protecting nerves from damage caused by high blood sugar levels.

2. How long should I take EPSTATE SR 150?

The duration of treatment depends on your response and the severity of symptoms. Always follow your doctor’s guidance.

3. Can EPSTATE SR 150 be taken with other diabetic medications?

Yes, but it should be done under medical supervision to avoid potential interactions and hypoglycemia.

4. Is EPSTATE SR 150 safe during pregnancy?

The safety of Epalrestat during pregnancy is not well established. Use only if clearly needed and prescribed by a physician.

5. What should I do if I miss a dose?

Take the missed dose as soon as you remember. If it's almost time for the next dose, skip the missed one. Do not double the dose.

6. Can I stop taking EPSTATE SR 150 if I feel better?

No. Continue the medication as prescribed to prevent recurrence or worsening of neuropathic symptoms.

Conclusion

EPSTATE SR 150 (Epalrestat 150 mg) is a valuable therapeutic option in the management of diabetic peripheral neuropathy, offering neuroprotection by targeting the biochemical pathways responsible for nerve damage. When used appropriately, it can significantly improve the quality of life for diabetic patients with nerve-related symptoms. Regular follow-up with healthcare providers is essential for monitoring treatment efficacy and safety.

About The Company

Steris Healthcare Pvt Ltd, widely recognized as Sterispharma, was established in February 2018 by a team of seasoned experts from the pharmaceutical sector. Based in Navi Mumbai, the company is proudly certified by WHO, GMP, and ISO, underscoring its unwavering commitment to quality and patient safety. Sterispharma is driven by a mission to make affordable, premium-quality medicines accessible throughout India, adhering strictly to WHO-recommended standards. Through its user-friendly online pharmacy platforms, customers can effortlessly order medications with home delivery services.

Sterispharma boasts an extensive portfolio of healthcare solutions, ranging from treatments for rare diseases to essential everyday healthcare needs. Their comprehensive product lineup addresses multiple therapeutic areas including Cardiology, Asthma, Respiratory Disorders, Nasal Care, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infective/Antibiotic Therapy, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental Care, and Dermatology. Medications are easily available for online purchase through their official websites — Sterisonline, Sterisindia, and Sterispharma — offering a seamless and reliable healthcare experience.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

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