Epstate SR 150 & Epalrestat Tablets ER (50mg). : Tablet - Steris Healthcare PVT LTD………

Epstate SR 150

Epalrestat Tablets ER (50mg)

Epstate SR 150 is a sustained-release medication containing Bupropion Hydrochloride, an atypical antidepressant and smoking cessation aid. It is commonly prescribed to manage major depressive disorder (MDD) and to aid in smoking cessation. The sustained-release formulation allows for a steady release of the medication over time, ensuring consistent therapeutic effects and improved patient compliance.

Composition

• Active Ingredient: Bupropion Hydrochloride (150mg)
• Excipients: Microcrystalline cellulose, hydroxypropyl methylcellulose, magnesium stearate, and other inactive ingredients that ensure the stability and efficacy of the tablet.

Mechanism of Action

Bupropion, the active component of Epstate SR 150, works by inhibiting the reuptake of norepinephrine and dopamine, two neurotransmitters involved in mood regulation and reward pathways. By preventing the reabsorption of these neurotransmitters, Bupropion increases their availability in the brain, which helps alleviate depressive symptoms and reduce cravings and withdrawal symptoms associated with smoking cessation.

Indications

Epstate SR 150 is indicated for:

• Major Depressive Disorder (MDD): Used to manage symptoms of depression, including low mood, loss of interest in activities, fatigue, and changes in appetite or sleep.
• Smoking Cessation: Aids in quitting smoking by reducing withdrawal symptoms and the urge to smoke.

Dosage and Administration

• Standard Dosage for MDD: The typical starting dose is 150mg once daily, which may be increased to 300mg per day (150mg twice daily) based on the patient’s response and the prescribing physician’s advice.
• Standard Dosage for Smoking Cessation: The initial dose is 150mg once daily for the first three days, then increased to 150mg twice daily. Treatment usually begins one to two weeks before the target quit date.
• Administration: Epstate SR 150 should be taken with or without food. Tablets should be swallowed whole, not crushed or chewed, to maintain the sustained-release properties.

Benefits

• Effective Antidepressant: Provides relief from depressive symptoms, improving mood and overall functioning.
• Smoking Cessation Aid: Helps reduce cravings and withdrawal symptoms, increasing the likelihood of successful quitting.
• Sustained-Release Formulation: Ensures a steady release of medication, reducing the frequency of dosing and improving patient adherence.
• Weight Neutral: Unlike some antidepressants, Bupropion is not typically associated with weight gain, making it a suitable option for patients concerned about weight changes.

Side Effects

While Epstate SR 150 is generally well-tolerated, it may cause some side effects, including:

• Insomnia: Difficulty sleeping is common, especially if taken later in the day.
• Dry Mouth: A frequent but manageable side effect.
• Headache: Some patients may experience headaches.
• Nausea and Vomiting: Gastrointestinal disturbances may occur, particularly during the initial phase of treatment.
• Increased Blood Pressure: Monitoring is recommended, especially for patients with hypertension.
• Seizures: Although rare, there is a risk of seizures, particularly at higher doses or in patients with predisposing factors.

Precautions and Warnings

• Seizure Risk: Patients with a history of seizures or eating disorders should use Epstate SR 150 with caution, as these conditions increase the risk of seizures.
• Alcohol Use: Excessive alcohol consumption should be avoided due to the increased risk of seizures.
• Regular Monitoring: Blood pressure should be monitored regularly, especially in patients with hypertension.
• Contraindications: Not recommended for patients with a history of seizure disorders, eating disorders, or those undergoing abrupt discontinuation of alcohol or sedatives.
• Pregnancy and Nursing: The safety of Bupropion during pregnancy and breastfeeding has not been established. It should only be used if the potential benefits justify the potential risks.

Drug Interactions

• MAO Inhibitors: Concurrent use with monoamine oxidase inhibitors (MAOIs) is contraindicated due to the risk of hypertensive reactions.
• Other Antidepressants: Caution is advised when combining with other antidepressants, particularly those that affect serotonin levels.
• Antipsychotics and Anticonvulsants: May increase the risk of seizures when used together.
• Nicotine Replacement Therapy: Combined use may increase the risk of hypertension.

Conclusion

Epstate SR 150, containing Bupropion Hydrochloride, offers an effective treatment for major depressive disorder and smoking cessation. Its mechanism of action, involving the inhibition of norepinephrine and dopamine reuptake, helps alleviate depressive symptoms and reduce cravings and withdrawal symptoms associated with quitting smoking. With benefits such as sustained-release formulation, effective antidepressant action, and support for smoking cessation, Epstate SR 150 is a valuable medication in managing these conditions. Regular monitoring and adherence to prescribed guidelines are crucial for maximizing therapeutic benefits and minimizing potential side effects. Epstate SR 150 remains a cornerstone in the treatment of depression and smoking cessation, helping patients achieve better mental health and improved quality of life.Steris Healthcare Pvt Ltd, founded by a group of expert professionals in the pharmaceutical industry in February 2018, operates as Sterispharma. This company, which is based in Navi Mumbai, holds certifications from WHO, GMP, and ISO. Its commitment is to provide high-quality drugs at affordable prices to its customers throughout India, following the rigorous guidelines set by the WHO. Steris offers the convenience of an online pharmacy where customers can easily buy medicines and enjoy the benefit of home delivery. At Steris, the mission is to supply a wide array of healthcare products designed to meet the varied needs of the medical community. Whether it is advanced treatments, medications for rare conditions, or basic health necessities, Sterispharma strives to serve the healthcare industry’s broad demands. The extensive product lineup from Steris includes treatments for various health areas such as Cardiology, Asthma, Respiratory issues, Nasal conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental care, and Dermatology.

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