Furosemide (20 mg) & Spironolactone (50mg) - Extended Release, Uses, & Side Effects.

Introduction

FRUSIP PLUS 20 is a combination diuretic formulation containing Furosemide (20 mg) and Spironolactone (50 mg). It is commonly prescribed for the management of edema (fluid retention) due to congestive heart failure, liver cirrhosis, or kidney disorders, and also used in the treatment of hypertension (high blood pressure).This powerful furosemide and spironolactone tablet balances fluid removal with potassium conservation, making it an ideal choice for patients at risk of electrolyte imbalance.

Composition

• Brand Name: FRUSIP PLUS 20

• Composition:

  • Furosemide 20 mg – a loop diuretic

  • Spironolactone 50 mg – a potassium-sparing diuretic

• Dosage Form: Oral Tablet

Key Uses of Furosemide and Spironolactone Tablet

FRUSIP PLUS 20 is prescribed for:

 Edema associated with:

• Congestive Heart Failure (CHF)

• Liver Cirrhosis with Ascites

• Chronic Kidney Disease or Nephrotic Syndrome

 Hypertension (High Blood Pressure)

 Hypokalemia Prevention in patients requiring potent diuretics

 Resistant Hypertension – especially in combination therapy

How FRUSIP PLUS 20 Works

This combination offers dual diuretic action:

• Furosemide is a loop diuretic that acts on the loop of Henle in the kidneys, enhancing the excretion of sodium, chloride, and water—thus reducing fluid overload and lowering blood pressure.

• Spironolactone is an aldosterone antagonist and potassium-sparing diuretic, preventing potassium loss and reducing sodium retention by acting on the distal renal tubules.

Together, they provide potent diuresis without significant potassium depletion, which is common in monotherapy with loop diuretics.

Benefits of FRUSIP PLUS 20

• Combines potent diuresis with potassium conservation

• Effective in reducing edema in heart, liver, or kidney disease

• Helps control blood pressure

• Minimizes the risk of hypokalemia

• Useful in long-term fluid management

• Convenient once or twice daily dosing

Dosage and Administration

• Usual Adult Dose: One tablet once or twice daily, or as directed by the physician

• Best taken in the morning or early afternoon to avoid nighttime urination

Important: Monitor electrolyte levels and kidney function regularly.

Side Effects

Though FRUSIP PLUS 20 is generally well-tolerated, potential side effects may include:

• Increased urination

• Low blood pressure (hypotension)

• Electrolyte disturbances (hyperkalemia or hyponatremia)

• Muscle cramps or dizziness

• Gynecomastia (rare, due to spironolactone)

• Headache or fatigue

 Seek medical help if you notice signs of high potassium like irregular heartbeat, muscle weakness, or confusion.

Precautions and Warnings

• Not suitable for patients with anuria or severe kidney dysfunction

• Use with caution in patients with diabetes, liver disease, or electrolyte imbalance

• Avoid use with potassium supplements or ACE inhibitors without medical supervision

• Pregnant or breastfeeding women should consult a doctor before use

FAQs – Furosemide and Spironolactone Tablet

Q1. What is FRUSIP PLUS 20 used for?

It is used to treat edema, fluid overload, and high blood pressure, especially in patients with heart, liver, or kidney disease.

Q2. Can I take this tablet daily?

Yes, but only under medical supervision. Prolonged use requires monitoring of electrolytes and renal function.

Q3. What makes this combination unique?

It combines loop diuresis from furosemide with potassium-sparing action of spironolactone, preventing hypokalemia while ensuring effective fluid removal.

Q4. Should I avoid any foods or supplements?

Avoid potassium-rich foods, salt substitutes, and potassium supplements unless prescribed.

Q5. When should I take it?

Preferably in the morning to minimize sleep disturbances due to frequent urination.

Conclusion

FRUSIP PLUS 20 offers a balanced and effective treatment for patients dealing with edema and hypertension, especially when potassium balance is a concern. With the combination of furosemide and spironolactone, it ensures maximum therapeutic effect with minimized risks, making it a preferred choice for long-term diuretic therapy.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

BUY NOW