GEFISTERIS 250 View Dosage, Side Effects, Price, Composition and More…..

GEFISTERIS 250

Gefitinib (250mg)

GEFISTERIS 250, containing Gefitinib 250mg, is a targeted therapy used primarily in the treatment of non-small cell lung cancer (NSCLC). As an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), Gefitinib plays a crucial role in interrupting the growth and spread of cancer cells.

Composition and Formulation:

Each GEFISTERIS 250 tablet comprises:

• Active Ingredient: Gefitinib 250mg
• Inactive Ingredients: Lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, povidone, magnesium stearate, and other excipients.

Mechanism of Action:

Gefitinib functions by inhibiting the EGFR tyrosine kinase enzyme, which is often overexpressed in cancer cells. This inhibition prevents the receptor from activating downstream signaling pathways that promote cancer cell proliferation and survival, leading to reduced tumor growth and enhanced cancer cell apoptosis.

Indications and Usage:

GEFISTERIS 250 is indicated for:

• First-line treatment of patients with locally advanced or metastatic NSCLC with specific mutations in the EGFR gene.
• It is particularly effective in patients who have shown no prior response to chemotherapy.

Dosage and Administration:

• Recommended Dose: The usual dose is one 250mg tablet taken orally once daily, with or without food.
• Missed Dose: If a dose is missed, it should be taken as soon as the patient remembers unless it is near the time for the next dose. In such cases, skip the missed dose and resume the regular schedule.
• Overdose: In case of overdose, seek immediate medical attention. Symptoms may include diarrhea, rash, and elevated liver enzymes.

Side Effects

Common side effects of Gefitinib include:

• Diarrhea
• Rash
• Acne
• Dry skin
• Nausea
• Vomiting
• Loss of appetite

Serious side effects may include:

• Interstitial lung disease
• Severe liver damage
• Gastrointestinal perforation
• Severe skin reactions

Precautions and Warnings:

• Pregnancy and Lactation: Gefitinib can harm an unborn baby. Women of childbearing age should use effective contraception during treatment and for at least two weeks after the last dose. It is not recommended for breastfeeding mothers.
• Liver Function: Regular monitoring of liver function tests is recommended, as Gefitinib can cause liver enzyme elevations.
• Drug Interactions: Gefitinib can interact with various medications, including warfarin, phenytoin, and certain antifungals. Patients should inform their healthcare provider of all medications they are taking.

Contraindications:

• Hypersensitivity to Gefitinib or any of the excipients in the formulation.
• Severe hypersensitivity reactions have been reported, which require immediate discontinuation of the drug.

Monitoring and Follow-Up:

• Liver Function Tests: Regular liver function tests are recommended to monitor for hepatotoxicity.
• Dermatologic Evaluation: Patients should be regularly evaluated for skin reactions and managed accordingly.
• Pulmonary Assessment: Monitoring for signs of interstitial lung disease is crucial, and any new or worsening respiratory symptoms should be evaluated promptly.

Storage and Handling:

• Store GEFISTERIS 250 tablets at room temperature (20-25°C) in a dry place, away from direct sunlight and moisture.
• Keep out of reach of children.

Conclusion:

GEFISTERIS 250 (Gefitinib 250mg) offers a targeted approach to treating EGFR mutation-positive NSCLC, providing an effective option for patients who have limited responses to traditional chemotherapy. Proper administration, monitoring, and awareness of potential side effects and interactions are essential for maximizing the benefits of this medication while minimizing risks. By understanding the uses, mechanisms, and precautions associated with GEFISTERIS 250, healthcare providers and patients can better navigate the complexities of cancer treatment, aiming for improved outcomes and quality of life. Steris Healthcare Pvt Ltd, established in February 2018 by seasoned professionals in the pharmaceutical sector, operates under the name Sterispharma. Headquartered in Navi Mumbai, the company is certified by WHO, GMP, and ISO. Sterispharma is dedicated to providing high-quality medications at affordable prices across India, adhering to stringent WHO guidelines. They offer an online pharmacy platform for easy medicine purchases and home delivery. The company's mission is to deliver a diverse range of healthcare products catering to the varied needs of the medical community. From advanced treatments and rare condition medications to essential health supplies, Sterispharma aims to meet the extensive demands of the healthcare industry. Their product range covers numerous health fields, including Cardiology, Asthma, Respiratory issues, Nasal conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental care, and Dermatology.

For further information: 

EMAIL:  info@sterispharma.com  / contact@sterispharma.com   

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