GLICLAGLAZE MET Tablet- View, Mechanism of action, Dosages......

gliclazide SR (60mg),Metformin SR (500 mg)

GLICLAGLAZE MET

gliclazide SR (60mg),Metformin SR (500 mg) combines GLICLAGLAZE MET to offer an effective treatment for Type 2 Diabetes Mellitus (T2DM). This dual therapy aims to improve glycemic control by leveraging the complementary actions of both medications. GLICLAGLAZE MET is designed for patients who need a comprehensive approach to manage their blood sugar levels.

Composition

Gliclazide SR (60mg): A sulfonylurea that stimulates insulin secretion from pancreatic beta cells.
Metformin SR (500mg): A biguanide that reduces hepatic glucose production and increases insulin sensitivity.

Mechanism of Action

Gliclazide SR

Gliclazide works by binding to specific receptors on pancreatic beta cells, leading to an increased release of insulin. This process is glucose-dependent, meaning that insulin is released primarily when blood sugar levels are high, reducing the risk of hypoglycemia.

Metformin SR

Metformin primarily acts on the liver to inhibit gluconeogenesis, the process by which glucose is produced from non-carbohydrate sources. It also enhances insulin sensitivity in peripheral tissues, allowing for more efficient glucose uptake by muscles.

Indications

GLICLAGLAZE MET is indicated for the management of Type 2 Diabetes Mellitus in adults. It is particularly useful for patients who:

• Have not achieved adequate glycemic control with diet and exercise alone.
• Require combination therapy to maintain optimal blood sugar levels.
• Are transitioning from other oral antidiabetic medications.

Dosage and Administration

Initial Dose

• One tablet of GLICLAGLAZE MET (Gliclazide SR 60mg, Metformin SR 500mg) once daily, preferably with a meal to enhance absorption and reduce gastrointestinal side effects.

Maintenance Dose

• Depending on glycemic control, the dosage may be adjusted. Regular monitoring of blood glucose levels is essential to tailor the dose to individual needs.

Benefits of GLICLAGLAZE MET

1. Enhanced Glycemic Control: The combination of Gliclazide and Metformin offers a synergistic effect, leading to better control of blood sugar levels.
2. Convenient Dosing: Sustained-release formulations of both drugs ensure a steady release of medication, reducing the need for multiple daily doses.
3. Reduced Risk of Hypoglycemia: Gliclazide’s glucose-dependent mechanism minimizes the risk of hypoglycemia compared to other sulfonylureas.
4. Weight Neutrality: Metformin is associated with weight neutrality or modest weight loss, making it suitable for overweight or obese patients.

Potential Side Effects

Common Side Effects

• Gliclazide: Hypoglycemia, dizziness, headache, nausea.
• Metformin: Gastrointestinal issues such as diarrhea, nausea, vomiting, abdominal pain, and a metallic taste.

Serious Side Effects

• Lactic Acidosis: A rare but serious complication associated with Metformin, characterized by symptoms like muscle pain, difficulty breathing, abdominal pain, and fatigue. Patients with renal impairment or conditions predisposing them to hypoxia are at higher risk.
• Severe Hypoglycemia: Though less common with Gliclazide, it can occur, especially in cases of overdose, inadequate caloric intake, or intense physical activity.

Precautions and Warnings

1. Renal Impairment: Regular monitoring of renal function is necessary, as Metformin is contraindicated in severe renal impairment.
2. Hepatic Impairment: Caution is advised in patients with liver dysfunction.
3. Alcohol Consumption: Alcohol can potentiate the hypoglycemic effect of Gliclazide and increase the risk of lactic acidosis with Metformin.
4. Pregnancy and Lactation: Consult a healthcare provider, as the safety of this combination in pregnant or breastfeeding women is not well established.

Drug Interactions

• Beta-blockers: May mask hypoglycemic symptoms.
• Diuretics: Can exacerbate hyperglycemia.
• ACE Inhibitors: May enhance the hypoglycemic effect of Gliclazide.
• Corticosteroids: Can increase blood sugar levels, counteracting the effects of GLICLAGLAZE MET.

Monitoring Parameters

1. Blood Glucose Levels: Regular self-monitoring to ensure adequate glycemic control.
2. HbA1c Levels: Periodic testing to assess long-term glycemic control.
3. Renal Function: Regular monitoring, especially in patients at risk for renal impairment.
4. Liver Function Tests: To detect any potential hepatic side effects.

Conclusion

GLICLAGLAZE MET provides a powerful combination therapy for managing Type 2 Diabetes Mellitus, combining the insulin-stimulating effects of Gliclazide with the glucose-lowering actions of Metformin. This medication helps achieve better glycemic control with a lower risk of hypoglycemia and added convenience of once-daily dosing. Always consult a healthcare provider to determine if GLICLAGLAZE MET is the right choice for your diabetes management plan. Steris Healthcare Pvt Ltd, established in February 2018 by seasoned professionals in the pharmaceutical sector, operates under the name Sterispharma. Headquartered in Navi Mumbai, the company is certified by WHO, GMP, and ISO. Sterispharma is dedicated to providing high-quality medications at affordable prices across India, adhering to stringent WHO guidelines. They offer an online pharmacy platform for easy medicine purchases and home delivery. The company's mission is to deliver a diverse range of healthcare products catering to the varied needs of the medical community. From advanced treatments and rare condition medications to essential health supplies, Sterispharma aims to meet the extensive demands of the healthcare industry. Their product range covers numerous health fields, including Cardiology, Asthma, Respiratory issues, Nasal conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental care, and Dermatology.

For further information: 

EMAIL:  info@sterispharma.com  / contact@sterispharma.com   

CALL/WHATSAPP: 7877551268, 7849827488

BUY NOW