Gliclazide

Introduction

GLICLAGLAZE MR 30 is a modified-release (MR) tablet containing Gliclazide (30 mg), a well-known oral antidiabetic medication from the sulfonylurea class. It is primarily prescribed for the management of type 2 diabetes mellitus (T2DM) in adults, helping to control blood sugar levels by stimulating insulin release from the pancreas. The sustained-release (SR) formulation ensures gradual drug release, offering prolonged efficacy and reducing the risk of sudden blood sugar fluctuations.

Managing diabetes effectively is crucial to prevent complications such as neuropathy, nephropathy, retinopathy, cardiovascular diseases, and other metabolic disorders. GLICLAGLAZE MR 30, when used alongside a balanced diet, regular exercise, and lifestyle modifications, plays a vital role in maintaining optimal glycemic control.

Key Ingredients

Each GLICLAGLAZE MR 30 tablet contains:

• Gliclazide (30 mg SR) – A sulfonylurea derivative that helps lower blood glucose levels by enhancing pancreatic insulin secretion.

• Excipients – These include lactose, microcrystalline cellulose, magnesium stearate, and hypromellose, which aid in controlled drug release.

How GLICLAGLAZE MR 30 Works

Gliclazide works through multiple mechanisms:

1. Stimulating Insulin Secretion: It binds to specific receptors on the pancreatic beta cells, enhancing insulin secretion in response to elevated blood sugar levels.

2. Improving Insulin Sensitivity: By improving peripheral glucose utilization, it helps reduce insulin resistance.

3. Regulating Glucose Absorption: The modified-release formulation ensures a steady release of the drug, minimizing postprandial glucose spikes.

4. Antioxidant and Vascular Benefits: Gliclazide has been shown to have antiplatelet and antioxidant properties, which contribute to improved microvascular health, reducing complications related to diabetes.

Key Benefits of GLICLAGLAZE MR 30

• Effective Blood Sugar Control: Helps in reducing fasting plasma glucose (FPG) and postprandial glucose (PPG).

• Once-Daily Dosing: Due to its sustained-release formulation, a single dose provides 24-hour glycemic control.

• Reduced Risk of Hypoglycemia: Compared to conventional sulfonylureas, Gliclazide MR has a lower incidence of hypoglycemia.

• Cardiovascular Protection: Studies suggest that Gliclazide may reduce the risk of macrovascular complications in diabetic patients.

• Weight-Neutral: Unlike some other sulfonylureas, Gliclazide MR is weight-neutral, making it suitable for overweight patients.

• Improved Beta-Cell Function: Helps preserve pancreatic beta-cell activity, delaying disease progression.

Dosage and Administration

Recommended Dosage

• Standard Dose: 30 mg once daily, preferably taken before breakfast.

• Dose Adjustment: Based on blood glucose levels, the dosage can be increased gradually up to 120 mg per day.

• Missed Dose: If a dose is missed, it should be taken as soon as remembered, but not doubled.

• Overdose Management: In case of overdose, symptoms of severe hypoglycemia (dizziness, confusion, sweating, palpitations) should be managed with glucose intake or emergency medical attention.

Administration Guidelines

• Swallow the tablet whole without crushing or chewing.

• Take it at the same time each day to maintain consistent blood sugar control.

• Combine with a healthy diet, regular exercise, and physician-recommended lifestyle changes.

Possible Side Effects of GLICLAGLAZE MR 30

While Gliclazide SR is generally well-tolerated, some patients may experience mild to moderate side effects, including:

Common Side Effects

• Mild Hypoglycemia (dizziness, sweating, hunger, confusion)

• Gastrointestinal Discomfort (nausea, diarrhea, abdominal pain)

• Headache

• Drowsiness or Fatigue

Rare but Serious Side Effects

• Severe Hypoglycemia (requires immediate medical attention)

• Liver Dysfunction (jaundice, elevated liver enzymes)

• Hematologic Reactions (anemia, leukopenia, thrombocytopenia)

• Allergic Reactions (skin rash, itching, swelling, difficulty breathing)

Seek medical attention if any severe adverse reactions occur.

Precautions and Warnings

• Not for Type 1 Diabetes: GLICLAGLAZE MR 30 is not effective for type 1 diabetes mellitus (T1DM) or diabetic ketoacidosis.

• Kidney or Liver Impairment: Use with caution in patients with renal or hepatic dysfunction.

• Pregnancy and Lactation: Not recommended during pregnancy or breastfeeding.

• Alcohol Interaction: Alcohol may increase the risk of hypoglycemia; limit intake.

• Drug Interactions:

  • Avoid concurrent use with beta-blockers, NSAIDs, corticosteroids, and antifungal medications, as they may alter blood sugar levels.

  • Combining with other oral antidiabetics or insulin should be done under medical supervision.

Price and Availability in India

• The price of GLICLAGLAZE MR 30 varies based on the brand, manufacturer, and location.

• Generally, a strip of 10 tablets costs between ₹50 – ₹150.

• Available at leading pharmacies, hospitals, and online stores.

• A valid doctor’s prescription is required for purchase.

Conclusion

GLICLAGLAZE MR 30 is an effective, well-tolerated, and convenient treatment for type 2 diabetes mellitus. Its sustained-release formulation ensures prolonged glucose control, reducing the risk of hypoglycemia and diabetic complications. When combined with a healthy lifestyle, proper diet, and regular physical activity, it significantly improves blood sugar management and overall quality of life. However, regular monitoring of blood glucose levels and consultation with a healthcare professional are essential for achieving optimal results.

For best outcomes, always follow your doctor’s guidance, and incorporate necessary lifestyle changes to manage diabetes effectively!

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

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