Gliclazide SR + Metformin SR

Introduction

GLICLAGLAZE MET is a combination medication containing Gliclazide SR (60mg) and Metformin SR (500mg), widely used in the management of type 2 diabetes mellitus (T2DM). This dual-action formulation helps control blood sugar levels by improving insulin sensitivity, reducing glucose production, and stimulating insulin secretion. GLICLAGLAZE MET is an effective oral antidiabetic medication that enhances glycemic control while minimizing the risk of complications associated with diabetes.

Key Ingredients

1. Gliclazide SR (60mg)

Gliclazide is a sulfonylurea class drug that works by stimulating the pancreas to release insulin, thereby reducing blood sugar levels. It also has antioxidant and anti-inflammatory properties, helping to prevent diabetic complications such as neuropathy and nephropathy. The sustained-release (SR) formulation ensures prolonged action and better glucose regulation.

2. Metformin SR (500mg)

Metformin is a biguanide class drug that primarily acts by reducing hepatic glucose production and increasing insulin sensitivity in peripheral tissues. It also helps in weight management by lowering glucose absorption in the intestines and promoting better energy utilization.

How Does GLICLAGLAZE MET Work?

The synergistic action of Gliclazide and Metformin helps maintain optimal blood sugar levels through multiple mechanisms:

• Gliclazide SR enhances insulin secretion from pancreatic beta cells, helping the body utilize glucose efficiently.

• Metformin SR reduces the amount of glucose produced by the liver and improves insulin sensitivity, allowing muscle cells to absorb glucose more effectively.

• The sustained-release (SR) formulations ensure a steady release of the medication into the bloodstream, reducing fluctuations in blood sugar levels.

Key Benefits of GLICLAGLAZE MET

• Better Blood Sugar Control: Helps in achieving stable and long-term glucose regulation in individuals with type 2 diabetes.

• Prevents Diabetes Complications: Reduces the risk of cardiovascular diseases, neuropathy, nephropathy, and retinopathy.

• Improves Insulin Sensitivity: Enhances the body’s ability to utilize insulin effectively.

• Weight Management: Metformin helps in controlling weight gain, making it a preferred choice for overweight diabetic patients.

• Sustained-Release Advantage: Provides steady and prolonged action, minimizing the chances of sudden sugar level drops (hypoglycemia).

• Enhances Cardiovascular Health: Gliclazide possesses antioxidant and anti-inflammatory properties, reducing oxidative stress in blood vessels.

Indications

GLICLAGLAZE MET is prescribed for individuals with Type 2 Diabetes Mellitus who require improved blood sugar control, especially when lifestyle modifications alone are insufficient.

Dosage & Administration

The dosage of GLICLAGLAZE MET should be determined by a healthcare provider based on the patient's condition, response to treatment, and blood glucose levels. The general dosage recommendations include:

• Usual Dose: One tablet per day with food, preferably with breakfast or dinner to reduce gastrointestinal side effects.

• Maximum Dose: Should not exceed two tablets per day, as prescribed by a doctor.

• Missed Dose: If a dose is missed, take it as soon as remembered. However, if it is close to the next dose, skip the missed dose and continue with the regular schedule.

Side Effects

While GLICLAGLAZE MET is generally well-tolerated, some individuals may experience mild to moderate side effects, including:

• Gastrointestinal Issues: Nausea, diarrhea, abdominal discomfort, or bloating due to Metformin.

• Hypoglycemia (Low Blood Sugar): May occur if taken in excess or without adequate food intake.

• Dizziness or Weakness: Due to fluctuations in blood sugar levels.

• Allergic Reactions: Skin rashes, itching, or swelling in rare cases.

• Lactic Acidosis (Rare but Serious): A potential side effect of Metformin, especially in patients with kidney impairment.

Precautions & Warnings

• Avoid Alcohol Consumption: Alcohol can increase the risk of lactic acidosis and hypoglycemia.

• Kidney & Liver Function: Regular monitoring is essential, as Metformin can cause lactic acidosis in patients with kidney dysfunction.

• Surgery or Medical Tests: Inform the doctor if undergoing surgery or medical imaging requiring contrast dye, as Metformin may need to be stopped temporarily.

• Pregnancy & Breastfeeding: Consult a doctor before using GLICLAGLAZE MET if pregnant or breastfeeding.

• Elderly Patients: Dosage adjustments may be needed due to age-related renal function decline.

Drug Interactions

GLICLAGLAZE MET may interact with certain medications, including:

• Other Antidiabetic Drugs: May enhance the risk of hypoglycemia when taken with insulin or other sulfonylureas.

• Beta-Blockers: Can mask symptoms of low blood sugar, making it harder to detect hypoglycemia.

• Diuretics & ACE Inhibitors: May increase the risk of lactic acidosis.

• Corticosteroids & Thyroid Medications: Can affect blood sugar control and may require dosage adjustments.

Lifestyle & Dietary Recommendations

For the best results with GLICLAGLAZE MET, patients should follow a healthy lifestyle:

• Balanced Diet: Include high-fiber foods, lean proteins, whole grains, and limit sugary foods and refined carbs.

• Regular Exercise: Helps in improving insulin sensitivity and maintaining a healthy weight.

• Stay Hydrated: Drinking enough water prevents dehydration and supports kidney function.

• Monitor Blood Sugar Levels: Regular self-monitoring helps in tracking progress and adjusting the treatment as needed.

• Avoid Smoking & Alcohol: Reduces the risk of complications like heart disease and nerve damage.

Price & Availability in India

The price of GLICLAGLAZE MET varies based on the brand and packaging. Generally, a strip of 10 tablets costs between ₹100-₹300 depending on the manufacturer. It is available at local pharmacies and online medical stores with a valid prescription.

Conclusion

GLICLAGLAZE MET, with its combination of Gliclazide SR (60mg) and Metformin SR (500mg), is an effective dual-action therapy for type 2 diabetes. It enhances insulin secretion, improves glucose metabolism, and minimizes complications associated with diabetes. When combined with a healthy diet, regular exercise, and lifestyle modifications, it plays a crucial role in maintaining optimal blood sugar control and promoting overall well-being.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

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