GLIDAPA TENE 10/20. :Tablet- View Uses, Side Effects, Dosage, Mechanism of action...

GLIDAPA TENE 10/20

Dapagliflozin & Teneligliptin

GLIDAPA TENE 10/20 is a combination pharmaceutical product containing Dapagliflozin (10mg) and Teneligliptin (20mg), two oral medications used primarily to manage type 2 diabetes. This combination leverages the complementary mechanisms of a sodium-glucose co-transporter 2 (SGLT2) inhibitor and a dipeptidyl peptidase-4 (DPP-4) inhibitor to effectively control blood glucose levels. This guide will cover all important aspects of GLIDAPA TENE 10/20, including its uses, dosage, side effects, and precautions.

Uses of GLIDAPA TENE 10/20

Management of Type 2 Diabetes

• Blood Sugar Control: GLIDAPA TENE 10/20 is used to help control blood sugar levels in individuals with type 2 diabetes. It is effective in reducing both fasting and postprandial (after meal) blood glucose levels.
• Combination Therapy: GLIDAPA TENE 10/20 can be used alone or in combination with other diabetes medications, such as metformin or to achieve optimal glycemic control.
• Prevention of Complications: By maintaining stable blood sugar levels, GLIDAPA TENE 10/20 helps reduce the risk of diabetes-related complications, including cardiovascular disease, neuropathy, nephropathy, and retinopathy.

Mechanism of Action

• Dapagliflozin (SGLT2 Inhibitor): Dapagliflozin works by inhibiting the sodium-glucose co-transporter 2 (SGLT2) in the kidneys, which reduces glucose reabsorption and increases glucose excretion in the urine. This helps lower blood glucose levels.
• Teneligliptin (DPP-4 Inhibitor): Teneligliptin works by inhibiting the enzyme dipeptidyl peptidase-4 (DPP-4), which increases the levels of incretin hormones. These hormones stimulate insulin secretion and inhibit glucagon release, both of which help lower blood glucose levels.

Dosage and Administration

Recommended Dosage

• The standard dose of GLIDAPA TENE 10/20 is one tablet taken once daily. The dosage may be adjusted based on the patient’s response and tolerance.

Administration Guidelines

• With or Without Food: GLIDAPA TENE 10/20 can be taken with or without food. Patients should follow their healthcare provider's instructions regarding food intake.
• Consistency: Take GLIDAPA TENE 10/20 at the same time each day to maintain consistent blood levels of the medication.
• Regular Monitoring: Patients should monitor their blood glucose levels regularly to evaluate the effectiveness of the medication and adjust the dosage if necessary, under the guidance of a healthcare provider.

Side Effects

Common Side Effects

• Urinary Tract Infections: Increased glucose excretion can lead to a higher risk of urinary tract infections.
• Genital Infections: Women may experience yeast infections, and men may experience balanitis (inflammation of the head of the penis).
• Gastrointestinal Issues: Some patients may experience nausea, diarrhea, or stomach discomfort.

Serious Side Effects

• Dehydration: Due to increased urination, there is a risk of dehydration. Symptoms include dizziness, lightheadedness, and thirst.
• Ketoacidosis: Although rare, SGLT2 inhibitors like Dapagliflozin can cause diabetic ketoacidosis, a serious condition characterized by high blood ketones.
• Pancreatitis: Teneligliptin has been associated with an increased risk of pancreatitis. Symptoms include severe abdominal pain, nausea, and vomiting.

Precautions and Warnings

Contraindications

• Severe Kidney Disease: GLIDAPA TENE 10/20 is contraindicated in patients with severe kidney impairment or end-stage renal disease.
• Hypersensitivity: Patients with a known allergy to Dapagliflozin, Teneligliptin, or any other component of the medication should not take GLIDAPA TENE 10/20.

Precautions

• Monitoring Renal Function: Regular monitoring of kidney function is recommended, as the medication is excreted through the kidneys.
• Heart Failure: Patients with a history of heart failure should use GLIDAPA TENE 10/20 with caution, as SGLT2 inhibitors can have a diuretic effect.

Drug Interactions

Medications to Avoid

• Diuretics: Co-administration with diuretics can increase the risk of dehydration and hypotension.
• Insulin and Sulfonylureas: Concurrent use with insulin or sulfonylureas can increase the risk of hypoglycemia. Dosage adjustments may be necessary.

Monitoring Required

• Blood Glucose Levels: Regular monitoring of blood glucose levels is essential to ensure that GLIDAPA TENE 10/20 is working effectively and to adjust dosages as needed.
• Renal Function Tests: Periodic kidney function tests help detect any potential renal-related side effects early.

Patient Management

Lifestyle Modifications

• Dietary Considerations: Patients should follow a balanced diet that aligns with their diabetes management plan. Avoiding excessive carbohydrate intake can enhance the effectiveness of GLIDAPA TENE 10/20.
• Exercise: Regular physical activity helps improve insulin sensitivity and overall blood glucose control. Patients should engage in regular, moderate exercise as recommended by their healthcare provider.
• Hydration: Staying well-hydrated is important, especially given the increased urination caused by Dapagliflozin.

Regular Follow-Ups

• Medical Appointments: Regular check-ups with a healthcare provider are crucial to monitor the effectiveness of GLIDAPA TENE 10/20 and adjust the treatment plan as necessary.
• Blood Tests: Periodic blood tests, including blood glucose levels and renal function tests, are essential to monitor the patient's response to the medication and detect any potential side effects early.

Conclusion

GLIDAPA TENE 10/20 is an effective combination medication for managing type 2 diabetes by controlling both fasting and postprandial blood glucose levels. Its dual mechanism of action, involving the inhibition of glucose reabsorption in the kidneys and the enhancement of insulin secretion, provides significant benefits to patients. While there are potential side effects and precautions to consider, regular monitoring and adherence to prescribed dosages can help manage these risks. Patients taking GLIDAPA TENE 10/20 should maintain open communication with their healthcare providers to ensure optimal treatment outcomes and address any concerns promptly. Understanding the uses, side effects, and precautions associated with GLIDAPA TENE 10/20 allows patients to manage their condition more effectively and improve their quality of life. Steris Healthcare Pvt Ltd, established in February 2018 by seasoned professionals in the pharmaceutical sector, operates under the name Sterispharma. Headquartered in Navi Mumbai, the company is certified by WHO, GMP, and ISO. Sterispharma is dedicated to providing high-quality medications at affordable prices across India, adhering to stringent WHO guidelines. They offer an online pharmacy platform for easy medicine purchases and home delivery. The company's mission is to deliver a diverse range of healthcare products catering to the varied needs of the medical community. From advanced treatments and rare condition medications to essential health supplies, Sterispharma aims to meet the extensive demands of the healthcare industry. Their product range covers numerous health fields, including Cardiology, Asthma, Respiratory issues, Nasal conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental care, and Dermatology.

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