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Dapagliflozin (10mg)

GLIDAPAFLOZIN 10

Dapagliflozin (10mg) which contains GLIDAPAFLOZIN 10, is a potent medication used to manage Type 2 Diabetes Mellitus (T2DM). As an SGLT2 inhibitor, Dapagliflozin works by promoting the excretion of excess glucose through urine, offering a unique mechanism to help control blood sugar levels. This medication provides not only glycemic control but also additional benefits such as weight loss and cardiovascular protection.

Composition

Dapagliflozin (10mg): A selective sodium-glucose co-transporter 2 (SGLT2) inhibitor that aids in lowering blood glucose levels by increasing glucose excretion through the kidneys.

Mechanism of Action

Dapagliflozin inhibits the SGLT2 protein in the proximal renal tubules, which is responsible for reabsorbing glucose back into the bloodstream. By blocking this protein, Dapagliflozin increases the amount of glucose excreted in the urine, thus lowering blood glucose levels. This process works independently of insulin, making it an effective option for a wide range of T2DM patients.

Indications

GLIDAPAFLOZIN 10 is indicated for the treatment of Type 2 Diabetes Mellitus in adults. It is particularly beneficial for patients who:

• Have not achieved adequate glycemic control with diet and exercise alone.
• Require additional therapy to maintain optimal blood sugar levels.
• Need combination therapy with other antidiabetic agents for better management.

Dosage and Administration

Initial Dose

• One tablet of GLIDAPAFLOZIN 10 (Dapagliflozin 10mg) taken once daily, preferably in the morning, with or without food.

Maintenance Dose

• Depending on the patient’s response and tolerance, the dosage may be maintained or adjusted. Regular monitoring of blood glucose levels is essential to tailor the treatment to individual needs.

Benefits of GLIDAPAFLOZIN 10

1. Improved Glycemic Control: Effectively lowers blood sugar levels by increasing glucose excretion.
2. Weight Loss: Patients often experience weight loss due to the calorie loss associated with glucose excretion.
3. Blood Pressure Reduction: Dapagliflozin has been shown to reduce systolic blood pressure, providing cardiovascular benefits.
4. Cardiovascular Protection: Clinical studies have demonstrated cardiovascular benefits in patients with existing heart conditions.
5. Renal Protection: Offers protective effects on the kidneys by reducing hyperfiltration and albuminuria.

Potential Side Effects

Common Side Effects

• Genital Infections: Increased risk of fungal infections due to higher glucose levels in the urine.
• Urinary Tract Infections: Elevated glucose concentration in the urine can predispose patients to UTIs.
• Dehydration: Increased urination may lead to dehydration, especially in patients with low fluid intake.

Serious Side Effects

• Ketoacidosis: Though rare, Dapagliflozin may cause diabetic ketoacidosis (DKA), even with normal blood sugar levels. Symptoms include nausea, vomiting, abdominal pain, and difficulty breathing.
• Hypotension: Due to its diuretic effect, Dapagliflozin can cause significant drops in blood pressure, leading to dizziness or fainting.

Precautions and Warnings

1. Renal Impairment: Not recommended for patients with severe renal impairment as it may not be effective and can increase the risk of adverse effects.
2. Volume Depletion: Monitor for signs of volume depletion, especially in patients on diuretics or with low blood pressure.
3. Elderly Patients: Use with caution in elderly patients who are at higher risk of volume depletion and renal function decline.
4. Pregnancy and Lactation: Safety during pregnancy and lactation has not been established. Consult a healthcare provider before use.

Drug Interactions

• Diuretics: Enhanced diuretic effect can increase the risk of dehydration and hypotension.
• Insulin and Insulin Secretagogues: Combination with these agents can increase the risk of hypoglycemia.
• Rifampicin: May reduce the efficacy of Dapagliflozin by increasing its metabolism.

Monitoring Parameters

1. Blood Glucose Levels: Regular self-monitoring to ensure adequate glycemic control.
2. HbA1c Levels: Periodic testing to assess long-term glycemic control.
3. Renal Function: Regular monitoring, especially in patients with pre-existing renal conditions.
4. Electrolyte Levels: Monitor for imbalances, particularly in patients on diuretics.

Conclusion

GLIDAPAFLOZIN 10, containing Dapagliflozin (10mg), offers a powerful and innovative approach to managing Type 2 Diabetes Mellitus. Its unique mechanism of action, along with additional benefits such as weight loss, blood pressure reduction, and cardiovascular protection, makes it an excellent choice for patients seeking comprehensive diabetes management. As always, it is essential to consult a healthcare provider to determine if GLIDAPAFLOZIN 10 is suitable for your treatment plan. Regular monitoring and adherence to prescribed dosages will help maximize the therapeutic benefits while minimizing potential risks.Steris Healthcare Pvt Ltd, established in February 2018 by seasoned professionals in the pharmaceutical sector, operates under the name Sterispharma. Headquartered in Navi Mumbai, the company is certified by WHO, GMP, and ISO. Sterispharma is dedicated to providing high-quality medications at affordable prices across India, adhering to stringent WHO guidelines. They offer an online pharmacy platform for easy medicine purchases and home delivery. The company's mission is to deliver a diverse range of healthcare products catering to the varied needs of the medical community. From advanced treatments and rare condition medications to essential health supplies, Sterispharma aims to meet the extensive demands of the healthcare industry. Their product range covers numerous health fields, including Cardiology, Asthma, Respiratory issues, Nasal conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental care, and Dermatology.

For further information: 

EMAIL:  info@sterispharma.com  / contact@sterispharma.com   

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