GLIDAPAFLOZIN 5 & Dapagliflozin (5mg) Tablet - Steris Healthcare PVT LTD………

Dapagliflozin (5mg)

GLIDAPAFLOZIN 5

Dapagliflozin (5mg), containing GLIDAPAFLOZIN 5, is a highly effective medication for the management of Type 2 Diabetes Mellitus (T2DM). This medication belongs to a class of drugs known as SGLT2 inhibitors, which work by promoting the excretion of glucose through the urine. This innovative mechanism helps patients achieve better glycemic control with additional benefits like weight loss and blood pressure reduction.

Composition

Dapagliflozin (5mg): An SGLT2 inhibitor that enhances urinary glucose excretion to lower blood sugar levels.

Mechanism of Action

Dapagliflozin works by inhibiting the sodium-glucose co-transporter 2 (SGLT2) in the proximal renal tubules. This inhibition prevents the reabsorption of glucose back into the bloodstream, leading to increased glucose excretion through urine. By reducing blood glucose levels independently of insulin, Dapagliflozin provides an alternative pathway for controlling hyperglycemia in T2DM patients.

Indications

GLIDAPAFLOZIN 5 is indicated for the treatment of Type 2 Diabetes Mellitus in adults, particularly in cases where:

• Diet and exercise alone do not provide adequate glycemic control.
• Additional therapy is required to maintain optimal blood sugar levels.
• Monotherapy or combination therapy with other antidiabetic agents is necessary.

Dosage and Administration

Initial Dose

• One tablet of GLIDAPAFLOZIN 5 (Dapagliflozin 5mg) taken once daily, preferably in the morning, with or without food.

Maintenance Dose

• Depending on the patient's response and tolerance, the dosage may be adjusted. Regular monitoring of blood glucose levels is essential to tailor the treatment to individual needs.

Benefits of GLIDAPAFLOZIN 5

1. Improved Glycemic Control: Dapagliflozin effectively lowers blood sugar levels by promoting glucose excretion.
2. Weight Loss: Patients may experience moderate weight loss due to the calorie loss associated with glucose excretion.
3. Blood Pressure Reduction: Dapagliflozin has been shown to reduce systolic blood pressure, providing cardiovascular benefits.
4. Cardiovascular Protection: SGLT2 inhibitors like Dapagliflozin have demonstrated cardiovascular benefits in patients with existing heart conditions.

Potential Side Effects

Common Side Effects

• Genital Infections: Increased risk of fungal infections due to higher glucose levels in the urine.
• Urinary Tract Infections: Higher glucose concentration in the urine can predispose patients to UTIs.
• Dehydration: Increased urination may lead to dehydration, especially in patients with low fluid intake.

Serious Side Effects

• Ketoacidosis: Though rare, patients may develop diabetic ketoacidosis (DKA), even with normal blood sugar levels. Symptoms include nausea, vomiting, abdominal pain, and difficulty breathing.
• Hypotension: Due to its diuretic effect, Dapagliflozin can cause a significant drop in blood pressure, leading to dizziness or fainting.

Precautions and Warnings

1. Renal Impairment: Not recommended for patients with severe renal impairment as it may not be effective and can increase the risk of adverse effects.
2. Volume Depletion: Monitor for signs of volume depletion, especially in patients on diuretics or with low blood pressure.
3. Elderly Patients: Use with caution in elderly patients who are at a higher risk of volume depletion and renal function decline.
4. Pregnancy and Lactation: Safety during pregnancy and lactation has not been established. Consult a healthcare provider before use.

Drug Interactions

• Diuretics: Enhanced diuretic effect can increase the risk of dehydration and hypotension.
• Insulin and Insulin Secretagogues: Combination with these agents can increase the risk of hypoglycemia.
• Rifampicin: May reduce the efficacy of Dapagliflozin by increasing its metabolism.

Monitoring Parameters

1. Blood Glucose Levels: Regular self-monitoring to ensure adequate glycemic control.
2. HbA1c Levels: Periodic testing to assess long-term glycemic control.
3. Renal Function: Regular monitoring, especially in patients with pre-existing renal conditions.
4. Electrolyte Levels: Monitor for imbalances, particularly in patients on diuretics.

Conclusion

GLIDAPAFLOZIN 5, containing Dapagliflozin (5mg), offers a novel approach to managing Type 2 Diabetes Mellitus. Its unique mechanism of action, coupled with additional benefits like weight loss and blood pressure reduction, makes it a valuable option for patients seeking improved glycemic control. As with any medication, it is essential to consult a healthcare provider to determine if GLIDAPAFLOZIN 5 is suitable for your diabetes management plan. Regular monitoring and adherence to prescribed dosages will help maximize the therapeutic benefits while minimizing potential risks. Steris Healthcare Pvt Ltd, established in February 2018 by seasoned professionals in the pharmaceutical sector, operates under the name Sterispharma. Headquartered in Navi Mumbai, the company is certified by WHO, GMP, and ISO. Sterispharma is dedicated to providing high-quality medications at affordable prices across India, adhering to stringent WHO guidelines. They offer an online pharmacy platform for easy medicine purchases and home delivery. The company's mission is to deliver a diverse range of healthcare products catering to the varied needs of the medical community. From advanced treatments and rare condition medications to essential health supplies, Sterispharma aims to meet the extensive demands of the healthcare industry. Their product range covers numerous health fields, including Cardiology, Asthma, Respiratory issues, Nasal conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental care, and Dermatology.

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