GLIDAPAFLOZIN M 10/1000 View Mechanism of Action,Dosage,Precautions........

Dapagliflozin (10mg), Metformin (1000mg)

GLIDAPAFLOZIN M 10/1000

Dapagliflozin (10mg), Metformin (1000mg) is an advanced combination therapy that brings together GLIDAPAFLOZIN M 10/1000 to effectively manage Type 2 Diabetes Mellitus (T2DM). This dual-action formula leverages the complementary mechanisms of both medications to offer enhanced glycemic control, weight management, and cardiovascular benefits. Designed for optimal convenience and efficacy, GLIDAPAFLOZIN M 10/1000 is ideal for patients seeking a comprehensive approach to diabetes care.

Composition

Dapagliflozin (10mg): An SGLT2 inhibitor that increases glucose excretion through urine.
Metformin (1000mg): A biguanide that decreases hepatic glucose production and improves insulin sensitivity.

Mechanism of Action

Dapagliflozin

Dapagliflozin inhibits the sodium-glucose co-transporter 2 (SGLT2) in the kidneys, reducing glucose reabsorption and increasing its excretion through urine. This mechanism helps lower blood glucose levels independently of insulin.

Metformin

Metformin primarily works by inhibiting hepatic gluconeogenesis, thereby reducing the amount of glucose produced by the liver. It also enhances insulin sensitivity in peripheral tissues, promoting better glucose uptake by muscles and fat cells.

Indications

GLIDAPAFLOZIN M 10/1000 is indicated for the treatment of Type 2 Diabetes Mellitus in adults. It is particularly beneficial for patients who:

• Have not achieved adequate glycemic control with diet and exercise alone.
• Require combination therapy to maintain optimal blood sugar levels.
• Are transitioning from monotherapy to a more effective dual therapy.

Dosage and Administration

Initial Dose

• One tablet of GLIDAPAFLOZIN M 10/1000 (Dapagliflozin 10mg, Metformin 1000mg) taken once daily, preferably with a meal to enhance absorption and reduce gastrointestinal side effects.

Maintenance Dose

• The dosage may be adjusted based on the patient's response and tolerance. Regular monitoring of blood glucose levels is essential to tailor the treatment to individual needs.

Benefits of GLIDAPAFLOZIN M 10/1000

1. Enhanced Glycemic Control: The combination of Dapagliflozin and Metformin provides a synergistic effect, leading to better management of blood sugar levels.
2. Weight Management: Dapagliflozin promotes weight loss due to the calorie loss associated with glucose excretion.
3. Cardiovascular Benefits: Dapagliflozin has been shown to reduce systolic blood pressure and provide cardiovascular protection.
4. Improved Compliance: Combining two effective medications into a single tablet simplifies the treatment regimen.
5. Reduced Risk of Hypoglycemia: The glucose-dependent action of Dapagliflozin and the weight-neutral effect of Metformin minimize the risk of hypoglycemia.

Potential Side Effects

Common Side Effects

• Dapagliflozin: Genital infections, urinary tract infections, increased urination, dehydration.
• Metformin: Gastrointestinal issues such as diarrhea, nausea, vomiting, and abdominal discomfort.

Serious Side Effects

• Ketoacidosis: Though rare, Dapagliflozin may cause diabetic ketoacidosis (DKA) even with normal blood sugar levels. Symptoms include nausea, vomiting, abdominal pain, and difficulty breathing.
• Lactic Acidosis: A rare but serious side effect of Metformin characterized by muscle pain, difficulty breathing, abdominal pain, and fatigue. Patients with renal impairment or conditions predisposing them to hypoxia are at higher risk.
• Hypotension: Due to its diuretic effect, Dapagliflozin can cause a significant drop in blood pressure, leading to dizziness or fainting.

Precautions and Warnings

1. Renal Impairment: Regular monitoring of renal function is necessary, as both Dapagliflozin and Metformin are contraindicated in severe renal impairment.
2. Volume Depletion: Monitor for signs of dehydration, especially in patients on diuretics or those with low blood pressure.
3. Elderly Patients: Use with caution in elderly patients who are at higher risk of volume depletion and renal function decline.
4. Pregnancy and Lactation: Consult a healthcare provider, as the safety of this combination in pregnant or breastfeeding women is not well established.

Drug Interactions

• Diuretics: Enhanced diuretic effect can increase the risk of dehydration and hypotension.
• Insulin and Insulin Secretagogues: Combination with these agents can increase the risk of hypoglycemia.
• Rifampicin: May reduce the efficacy of Dapagliflozin by increasing its metabolism.
• Cimetidine: May increase the effects of Metformin by reducing its renal clearance.

Monitoring Parameters

1. Blood Glucose Levels: Regular self-monitoring to ensure adequate glycemic control.
2. HbA1c Levels: Periodic testing to assess long-term glycemic control.
3. Renal Function: Regular monitoring, especially in patients with pre-existing renal conditions.
4. Electrolyte Levels: Monitor for imbalances, particularly in patients on diuretics.

Conclusion

GLIDAPAFLOZIN M 10/1000, combining Dapagliflozin (10mg) and Metformin (1000mg), offers a comprehensive solution for managing Type 2 Diabetes Mellitus. This medication not only improves glycemic control but also provides additional benefits such as weight loss, cardiovascular protection, and enhanced patient compliance. As always, it is essential to consult a healthcare provider to determine if GLIDAPAFLOZIN M 10/1000 is the right choice for your diabetes management plan. Regular monitoring and adherence to prescribed dosages will help maximize the therapeutic benefits while minimizing potential risks. Steris Healthcare Pvt Ltd, established in February 2018 by seasoned professionals in the pharmaceutical sector, operates under the name Sterispharma. Headquartered in Navi Mumbai, the company is certified by WHO, GMP, and ISO. Sterispharma is dedicated to providing high-quality medications at affordable prices across India, adhering to stringent WHO guidelines. They offer an online pharmacy platform for easy medicine purchases and home delivery. The company's mission is to deliver a diverse range of healthcare products catering to the varied needs of the medical community. From advanced treatments and rare condition medications to essential health supplies, Sterispharma aims to meet the extensive demands of the healthcare industry. Their product range covers numerous health fields, including Cardiology, Asthma, Respiratory issues, Nasal conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental care, and Dermatology.

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