GLIDAPAFLOZIN M 10/500 & Dapagliflozin (10mg), Metformin (500mg) Tablet - Steris Healthcare PVT LTD….

Dapagliflozin (10mg), Metformin (500mg)

GLIDAPAFLOZIN M 10/500

Dapagliflozin (10mg), Metformin (500mg) SR combines GLIDAPAFLOZIN M 10/500 to provide a powerful treatment option for Type 2 Diabetes Mellitus (T2DM). This combination therapy harnesses the complementary actions of both medications to offer improved glycemic control, weight management, and cardiovascular benefits. Designed for convenience and efficacy, GLIDAPAFLOZIN M 10/500 is ideal for patients seeking a comprehensive approach to diabetes management.

Composition

Dapagliflozin (10mg): An SGLT2 inhibitor that increases glucose excretion through urine.
Metformin SR (500mg): A sustained-release biguanide that decreases hepatic glucose production and enhances insulin sensitivity.

Mechanism of Action

Dapagliflozin

Dapagliflozin works by inhibiting the sodium-glucose co-transporter 2 (SGLT2) in the kidneys, which reduces glucose reabsorption and increases its excretion through urine. This helps lower blood glucose levels independently of insulin, providing an effective mechanism for controlling hyperglycemia.

Metformin SR

Metformin SR (Sustained Release) primarily acts on the liver to inhibit gluconeogenesis, the production of glucose from non-carbohydrate sources. Additionally, it enhances insulin sensitivity in peripheral tissues, facilitating better glucose uptake by muscles and fat cells. The sustained-release formulation ensures a gradual release of the medication, minimizing gastrointestinal side effects and improving patient compliance.

Indications

GLIDAPAFLOZIN M 10/500 is indicated for the treatment of Type 2 Diabetes Mellitus in adults. It is particularly beneficial for patients who:

• Have not achieved adequate glycemic control with diet and exercise alone.
• Require combination therapy to maintain optimal blood sugar levels.
• Are transitioning from monotherapy to a more effective dual therapy.

Dosage and Administration

Initial Dose

• One tablet of GLIDAPAFLOZIN M 10/500 (Dapagliflozin 10mg, Metformin SR 500mg) taken once daily, preferably with a meal to enhance absorption and reduce gastrointestinal side effects.

Maintenance Dose

• Dosage adjustments may be made based on the patient's response and tolerance. Regular monitoring of blood glucose levels is essential to tailor the treatment to individual needs.

Benefits of GLIDAPAFLOZIN M 10/500

1. Enhanced Glycemic Control: The combination of Dapagliflozin and Metformin SR provides a synergistic effect, leading to better management of blood sugar levels.
2. Weight Management: Dapagliflozin promotes weight loss due to the calorie loss associated with glucose excretion.
3. Cardiovascular Benefits: Dapagliflozin has been shown to reduce systolic blood pressure and provide cardiovascular protection.
4. Improved Compliance: The sustained-release formulation of Metformin ensures a gradual release, reducing gastrointestinal discomfort and improving adherence to the treatment regimen.
5. Reduced Risk of Hypoglycemia: The glucose-dependent action of Dapagliflozin and the weight-neutral effect of Metformin minimize the risk of hypoglycemia.

Potential Side Effects

Common Side Effects

• Dapagliflozin: Genital infections, urinary tract infections, increased urination, dehydration.
• Metformin SR: Gastrointestinal issues such as diarrhea, nausea, vomiting, and abdominal discomfort.

Serious Side Effects

• Ketoacidosis: Though rare, Dapagliflozin may cause diabetic ketoacidosis (DKA) even with normal blood sugar levels. Symptoms include nausea, vomiting, abdominal pain, and difficulty breathing.
• Lactic Acidosis: A rare but serious side effect of Metformin characterized by muscle pain, difficulty breathing, abdominal pain, and fatigue. Patients with renal impairment or conditions predisposing them to hypoxia are at higher risk.
• Hypotension: Due to its diuretic effect, Dapagliflozin can cause a significant drop in blood pressure, leading to dizziness or fainting.

Precautions and Warnings

1. Renal Impairment: Regular monitoring of renal function is necessary, as both Dapagliflozin and Metformin SR are contraindicated in severe renal impairment.
2. Volume Depletion: Monitor for signs of dehydration, especially in patients on diuretics or those with low blood pressure.
3. Elderly Patients: Use with caution in elderly patients who are at higher risk of volume depletion and renal function decline.
4. Pregnancy and Lactation: Consult a healthcare provider, as the safety of this combination in pregnant or breastfeeding women is not well established.

Drug Interactions

• Diuretics: Enhanced diuretic effect can increase the risk of dehydration and hypotension.
• Insulin and Insulin Secretagogues: Combination with these agents can increase the risk of hypoglycemia.
• Rifampicin: May reduce the efficacy of Dapagliflozin by increasing its metabolism.
• Cimetidine: May increase the effects of Metformin by reducing its renal clearance.

Monitoring Parameters

1. Blood Glucose Levels: Regular self-monitoring to ensure adequate glycemic control.
2. HbA1c Levels: Periodic testing to assess long-term glycemic control.
3. Renal Function: Regular monitoring, especially in patients with pre-existing renal conditions.
4. Electrolyte Levels: Monitor for imbalances, particularly in patients on diuretics.

Conclusion

GLIDAPAFLOZIN M 10/500, combining Dapagliflozin (10mg) and Metformin SR (500mg), offers a robust solution for managing Type 2 Diabetes Mellitus. This medication not only improves glycemic control but also provides additional benefits such as weight loss, cardiovascular protection, and enhanced patient compliance. As always, it is essential to consult a healthcare provider to determine if GLIDAPAFLOZIN M 10/500 is the right choice for your diabetes management plan. Regular monitoring and adherence to prescribed dosages will help maximize the therapeutic benefits while minimizing potential risks. Steris Healthcare Pvt Ltd, established in February 2018 by seasoned professionals in the pharmaceutical sector, operates under the name Sterispharma. Headquartered in Navi Mumbai, the company is certified by WHO, GMP, and ISO. Sterispharma is dedicated to providing high-quality medications at affordable prices across India, adhering to stringent WHO guidelines. They offer an online pharmacy platform for easy medicine purchases and home delivery. The company's mission is to deliver a diverse range of healthcare products catering to the varied needs of the medical community. From advanced treatments and rare condition medications to essential health supplies, Sterispharma aims to meet the extensive demands of the healthcare industry. Their product range covers numerous health fields, including Cardiology, Asthma, Respiratory issues, Nasal conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental care, and Dermatology.

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