glisaxapin 5

Introduction

GLISAXAPIN 5 is an oral anti-diabetic medication containing Saxagliptin (5mg), a DPP-4 inhibitor that helps manage type 2 diabetes mellitus. It improves glycemic control by increasing insulin secretion and reducing glucose production. Diabetes is a chronic metabolic disorder characterized by high blood sugar levels, and effective management is crucial to preventing complications such as neuropathy, nephropathy, and cardiovascular diseases.

Key Ingredients

The primary ingredient in GLISAXAPIN 5 is Saxagliptin (5mg), which belongs to the dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs.

Mechanism of Action

Saxagliptin works by inhibiting the DPP-4 enzyme, which degrades incretin hormones such as GLP-1 (glucagon-like peptide-1) and GIP (gastric inhibitory polypeptide). These hormones play a key role in regulating blood glucose levels by:

• Stimulating insulin release from the pancreas in response to food intake.

• Suppressing glucagon secretion, which reduces glucose production in the liver.

• Slowing gastric emptying to prevent rapid glucose absorption.

By preserving incretin hormone activity, Saxagliptin effectively reduces both fasting and postprandial blood sugar levels.

Uses of GLISAXAPIN 5

GLISAXAPIN 5 is prescribed for the management of type 2 diabetes mellitus in adults. It is used as:

• Monotherapy for patients who do not achieve adequate glycemic control with diet and exercise alone.

• Combination therapy with other antidiabetic agents like Metformin, Sulfonylureas, or Insulin when additional glucose-lowering effects are needed.

• A preferred option for individuals intolerant to medications such as Sulfonylureas or Thiazolidinediones.

Benefits of GLISAXAPIN 5

• Effective Blood Sugar Control: Lowers HbA1c levels, an indicator of long-term glycemic control.

• Low Risk of Hypoglycemia: Unlike Sulfonylureas, it does not cause excessive insulin release, reducing the risk of dangerously low blood sugar levels.

• Weight Neutral: Does not promote weight gain, making it a suitable choice for overweight or obese individuals.

• Convenient Dosage: Taken once daily, making adherence easier for patients.

• Cardiovascular Safety: Studies indicate that Saxagliptin does not increase the risk of major cardiovascular events.

Dosage and Administration

The recommended dosage of GLISAXAPIN 5 is one tablet (5mg) per day, with or without food.

• For patients with moderate to severe renal impairment, the dose may need adjustment as prescribed by a healthcare provider.

• It should be taken at the same time each day to maintain consistent blood levels.

• Avoid missing doses, and if a dose is forgotten, it should be taken as soon as possible unless it is near the time for the next dose.

Side Effects of GLISAXAPIN 5

While generally well-tolerated, GLISAXAPIN 5 may cause certain side effects, including:

Common Side Effects:

• Headache

• Upper respiratory tract infections

• Urinary tract infections

• Nasopharyngitis (common cold)

• Joint pain

Rare but Serious Side Effects:

• Pancreatitis: Symptoms include severe abdominal pain, nausea, and vomiting.

• Heart Failure: Patients with a history of heart disease should use it cautiously.

• Hypersensitivity Reactions: Rash, hives, or difficulty breathing may indicate an allergic reaction.

• Severe Joint Pain: Some patients may experience debilitating joint pain, which usually resolves after discontinuing the medication.

• Hypoglycemia: More likely when used in combination with Insulin or Sulfonylureas.

Drug Interactions

GLISAXAPIN 5 may interact with certain medications, altering its effectiveness or increasing the risk of side effects. Some key interactions include:

• Strong CYP3A4 inhibitors (e.g., Ketoconazole, Ritonavir): May increase Saxagliptin levels, requiring dose adjustment.

• Insulin and Sulfonylureas: Increased risk of hypoglycemia; dose modifications may be needed.

• Diuretics and Antihypertensive Drugs: May alter glucose metabolism and require monitoring.

Precautions and Warnings

• Renal Impairment: Dose adjustment is necessary in patients with kidney disease.

• Hepatic Impairment: Limited data is available on its use in liver disease.

• Pregnancy and Lactation: Should be used only if prescribed by a healthcare provider after evaluating potential risks and benefits.

• Surgery and Stress Conditions: Blood sugar levels may fluctuate during surgery or stress, requiring alternative management.

• Pediatric Use: Not recommended for individuals under 18 years due to a lack of safety data.

Price and Availability

The cost of GLISAXAPIN 5 varies depending on location and pharmacy. In India, the average price ranges between ₹300-₹500 for a strip of 10 tablets. However, prices may fluctuate based on generic alternatives and brand variations.

Storage Instructions

• Store at room temperature (15°C - 30°C), away from moisture and direct sunlight.

• Keep out of reach of children.

• Do not use expired medication.

Frequently Asked Questions (FAQs)

1. Can GLISAXAPIN 5 be taken with food?

Yes, it can be taken with or without food.

2. Is it safe for elderly patients?

Yes, but caution is advised, especially in patients with kidney disease or heart failure.

3. How long does it take for Saxagliptin to show effects?

Blood sugar levels may start improving within a few days, but optimal effects are seen after several weeks of regular use.

4. Can I stop taking GLISAXAPIN 5 suddenly?

No, discontinuation should be done under medical supervision to avoid blood sugar fluctuations.

5. Is it safe to consume alcohol while taking GLISAXAPIN 5?

Alcohol consumption should be limited, as it can increase the risk of hypoglycemia and worsen diabetes-related complications.

Conclusion

GLISAXAPIN 5 (Saxagliptin 5mg) is an effective medication for managing type 2 diabetes mellitus. It provides stable blood sugar control, has a low risk of hypoglycemia, and is weight-neutral, making it a favorable choice for many patients. However, it should be used under medical supervision, with regular monitoring to ensure safety and effectiveness. Patients should adhere to prescribed dosage, maintain a healthy lifestyle, and consult their healthcare provider for personalized diabetes management.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

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