GLISITAPTIN M 1000 Mg : Uses, Side Effects, Dosage & More…

Introduction

GLISITAPTIN M 1000 is an oral antidiabetic medication designed to help manage Type 2 Diabetes Mellitus (T2DM) effectively. It combines Sitagliptin Phosphate (50mg) and Metformin Hydrochloride (1000mg), two potent agents that work synergistically to control blood sugar levels. This dual therapy enhances insulin sensitivity, reduces glucose production in the liver, and increases insulin secretion in response to meals.

For individuals struggling to maintain glycemic control with Metformin alone, GLISITAPTIN M 1000 offers an advanced DPP-4 inhibitor + biguanide combination to optimize diabetes management.

Key Ingredients of GLISITAPTIN M 1000

1. Sitagliptin Phosphate (50mg)

Sitagliptin is a Dipeptidyl Peptidase-4 (DPP-4) inhibitor that helps increase insulin secretion and lower glucagon levels after meals. By preventing the breakdown of incretin hormones (GLP-1 and GIP), it enhances the body's ability to regulate blood glucose levels.

2. Metformin Hydrochloride (1000mg)

Metformin is a biguanide class drug that lowers blood sugar by reducing hepatic glucose production, increasing peripheral glucose uptake, and improving insulin sensitivity. It does not stimulate insulin secretion, reducing the risk of hypoglycemia.

Together, these ingredients complement each other, offering better glycemic control than either drug alone.

How Does GLISITAPTIN M 1000 Work?

GLISITAPTIN M 1000 works through multiple mechanisms to regulate blood sugar:

1. Enhances Insulin Secretion

Sitagliptin prolongs the action of incretin hormones, which stimulate the pancreas to release insulin in response to food intake.

2. Reduces Hepatic Glucose Production

Metformin inhibits excess glucose production in the liver, preventing hyperglycemia.

3. Improves Insulin Sensitivity

Metformin enhances the ability of muscle and fat cells to absorb glucose, reducing insulin resistance.

4. Lowers Glucagon Secretion

Sitagliptin suppresses glucagon, a hormone responsible for increasing blood glucose levels.

5. Supports Weight Management

This combination therapy is often associated with modest weight loss or weight neutrality, making it a preferred choice for overweight individuals with diabetes.

Uses of GLISITAPTIN M 1000

GLISITAPTIN M 1000 is primarily prescribed for:

Type 2 Diabetes Mellitus (T2DM): Helps achieve stable blood sugar control when lifestyle modifications and Metformin alone are insufficient.
Glycemic Control: Effectively lowers HbA1c levels over time.
Postprandial Blood Sugar Management: Reduces post-meal glucose spikes.
Long-Term Diabetes Management: Prevents complications like neuropathy, nephropathy, and cardiovascular diseases.

Dosage and Administration

Recommended Dosage

• Typical Dose: One tablet once or twice daily, preferably with meals to reduce gastrointestinal side effects.
• Dosage Adjustments: May be altered based on renal function, age, and response to treatment.
• Missed Dose: If a dose is missed, take it as soon as possible unless it's almost time for the next dose.

Who Should Take It?

 Adults with Type 2 Diabetes Mellitus
 Patients with inadequate glycemic control on Metformin alone
 Individuals at risk of high post-meal glucose levels

Who Should Avoid It?

 Patients with Type 1 Diabetes or Diabetic Ketoacidosis
 Those with severe kidney or liver disease
 Individuals with a history of lactic acidosis
 Pregnant or breastfeeding women (unless advised by a doctor)

Potential Side Effects of GLISITAPTIN M 1000

Like all medications, GLISITAPTIN M 1000 may cause some side effects. However, most are mild and temporary.

Common Side Effects

Nausea and Vomiting
Diarrhea
Abdominal discomfort
Mild headaches
Nasopharyngitis (Cold Symptoms)

Serious Side Effects (Rare)

Lactic Acidosis – A rare but serious condition linked to Metformin accumulation, causing symptoms like weakness, muscle pain, difficulty breathing, and dizziness.
Pancreatitis – Severe abdominal pain, nausea, and vomiting.
Allergic Reactions – Rash, swelling, or difficulty breathing.

If you experience severe or persistent symptoms, consult your doctor immediately.

Precautions and Warnings

1. Kidney Function Monitoring

• Metformin is excreted via the kidneys, so patients with renal impairment should undergo regular kidney function tests (eGFR monitoring).

2. Alcohol Consumption

• Excessive alcohol intake increases the risk of lactic acidosis, so avoid heavy drinking.

3. Heart Disease Risk

• GLISITAPTIN M 1000 is generally safe for heart patients, but individuals with a history of heart failure should consult their doctor.

4. Surgery and Medical Tests

• Discontinue Metformin before major surgical procedures or contrast dye-based imaging scans to prevent kidney-related complications.

5. Pregnancy and Breastfeeding

• Not recommended during pregnancy unless prescribed.
• Sitagliptin and Metformin may pass into breast milk.

Drug Interactions

GLISITAPTIN M 1000 may interact with:

Diuretics – Can increase the risk of lactic acidosis.
Beta-Blockers – May mask symptoms of low blood sugar.
Steroids – Can elevate blood glucose levels.
NSAIDs – May impair kidney function.
Other Antidiabetic Drugs – Combining with sulfonylureas or insulin may increase the risk of hypoglycemia.

Always inform your doctor about all medications you are taking.

Price and Availability in India

The price of GLISITAPTIN M 1000 may vary depending on the brand and pharmacy. On average, a strip of 10 tablets costs around ₹200-₹400 in India. It is available at leading pharmacies and online stores.

Conclusion: Why Choose GLISITAPTIN M 1000?

Powerful Dual Therapy – Combines Sitagliptin (50mg) and Metformin (1000mg) for superior glycemic control.
Reduces HbA1c Levels – Helps maintain long-term diabetes management.
Lower Risk of Hypoglycemia – Compared to sulfonylureas or insulin therapy.
Weight-Friendly – Helps maintain or reduce weight, unlike some antidiabetic drugs.
Convenient Dosing – Easy-to-take oral tablets for daily diabetes care.

GLISITAPTIN M 1000 is a trusted choice for managing Type 2 Diabetes Mellitus, ensuring better blood sugar control, fewer complications, and improved quality of life.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

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