Granisetron Hydrochloride 1mg: Uses, Dosage, Side Effects, Price in India, and More

Introduction

GRANISTROM 1 is a highly effective antiemetic formulation containing Granisetron Hydrochloride 1mg, specifically designed to prevent and manage nausea and vomiting associated with chemotherapy, radiotherapy, and post-operative recovery. Granisetron is a selective 5-HT3 receptor antagonist, which works by blocking serotonin – a chemical responsible for triggering nausea and vomiting.This tablet offers fast-acting, long-lasting relief and is widely trusted in oncology and surgical settings for patient comfort and quality of life enhancement.

Composition

Each tablet of GRANISTROM 1 contains:

• Granisetron Hydrochloride – 1 mg

• Dosage Form – Oral Tablet

• Route of Administration – Oral

• Packaging – Blister packs

Mechanism of Action

Granisetron Hydrochloride acts as a potent 5-HT3 receptor antagonist, primarily in the vagal nerve terminals and chemoreceptor trigger zone (CTZ) in the brain. During chemotherapy or surgery, serotonin is released in the gut, stimulating these receptors and causing nausea. Granisetron blocks this signal, thereby preventing emesis at the source.

Key Features

• High-affinity 5-HT3 receptor blockade

• Fast-acting onset with long duration of antiemetic effect

• Minimal sedation or extrapyramidal side effects

• Effective in both acute and delayed CINV (Chemotherapy-Induced Nausea and Vomiting)

• Convenient once or twice daily dosing

Indications / Uses

GRANISTROM 1 (Granisetron Hydrochloride 1mg) is indicated for:

• Prevention and treatment of chemotherapy-induced nausea and vomiting (CINV)

• Radiotherapy-induced nausea and vomiting

• Postoperative nausea and vomiting (PONV)

It is widely prescribed in oncology departments, daycare chemotherapy units, and perioperative care centers for nausea control.

Benefits of GRANISTROM 1

• Rapid symptom relief within 30 minutes of administration

• Effective even in highly emetogenic chemotherapy cycles

• Well-tolerated, non-sedating profile

• Helps maintain nutritional intake by controlling vomiting

• Improves patient compliance and comfort during therapy

Dosage and Administration

• Standard Dose: 1 mg orally, 1 hour before chemotherapy or radiation

• May be repeated after 12 hours if necessary

• Should be taken with or without food, as directed by a physician

Note: Dosage may vary based on patient weight, therapy intensity, or treatment protocol. Always follow physician guidance.

Side Effects and Precautions

Common Side Effects:

• Headache

• Constipation

• Dizziness

• Fatigue

Rare but serious reactions may include:

• Allergic reactions

• QT prolongation (in patients with cardiac conditions)

Precautions:

• Use with caution in patients with known cardiac arrhythmias

• Not recommended for use during pregnancy unless prescribed

• Avoid concurrent use with other QT-prolonging agents

Drug Interactions

Granisetron is generally safe but may interact with:

• Antiarrhythmic medications

• SSRIs or SNRIs

• Other 5-HT3 antagonists

Spacing doses and consulting with a healthcare provider is essential when taking multiple medications.

FAQs

Q1. What is Granisetron Hydrochloride used for?
Granisetron Hydrochloride is used to prevent nausea and vomiting caused by chemotherapy, radiotherapy, and surgeries.

Q2. Is GRANISTROM 1 safe for daily use during chemotherapy cycles?
Yes, it is commonly used before and after chemotherapy sessions to control vomiting, as prescribed by your oncologist.

Q3. How fast does GRANISTROM 1 work?
It typically starts working within 30 to 60 minutes and provides relief for up to 24 hours.

Q4. Can this be used in children?
Yes, with adjusted dosing and only under pediatric supervision.

Q5. What is the difference between Granisetron and Ondansetron?
Both are 5-HT3 antagonists, but Granisetron Hydrochloride has a longer half-life and may be preferred in delayed nausea control during chemotherapy.

Conclusion

GRANISTROM 1, with Granisetron Hydrochloride 1mg, is a trusted and clinically proven solution for managing severe nausea and vomiting during chemotherapy, radiotherapy, and surgeries. Its superior tolerability and long-lasting action make it a preferred choice in oncology support therapy.If you are looking to support your patients through difficult treatment phases with comfort and care, GRANISTROM 1 is your reliable partner.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

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