Isosorbide Dinitrate 5mg Tablet – Complete Guide to CARDULES ISDN 5

Introduction

CARDULES ISDN 5 is a prescription medication containing Isosorbide Dinitrate 5 mg, a nitrate class vasodilator used to prevent and manage angina pectoris (chest pain) due to coronary artery disease. It works by relaxing and widening blood vessels, improving blood flow to the heart and reducing its oxygen demand.

Isosorbide Dinitrate 5 mg Uses

CARDULES ISDN 5 is used in the treatment of:

1. Chronic Stable Angina: Prevents episodes of chest pain caused by reduced blood flow to the heart.

2. Variant (Prinzmetal's) Angina: Helps relieve and prevent vasospastic chest pain due to coronary artery spasm.

3. Congestive Heart Failure (Adjunct Therapy): Reduces cardiac workload in combination with other heart failure medications.

4. Myocardial Infarction (Post-MI Care): Improves oxygen delivery post-heart attack.

5. Pulmonary Hypertension (Off-label use): Occasionally used under specialist guidance.

How CARDULES ISDN 5 Works

Isosorbide Dinitrate is converted into nitric oxide in the body, which activates guanylate cyclase. This increases cyclic GMP levels, resulting in vascular smooth muscle relaxation. This process:

• Dilates venous capacitance vessels, reducing preload

• Slightly dilates arterial vessels, reducing afterload

• Improves oxygen delivery to the myocardium (heart muscle)

Dosage and Administration

• Usual Adult Dose: 5 mg two or three times daily, as prescribed.

• Administration: Take orally with or without food. Maintain consistent timing each day.

• Important Note: Avoid sudden discontinuation; taper under medical supervision.

To reduce tolerance, ensure a nitrate-free interval of at least 10–12 hours in 24 hours, especially with chronic use.

Side Effects of Isosorbide Dinitrate 5 mg

Common side effects include:

• Headache (most common)

• Dizziness or lightheadedness

• Flushing

• Low blood pressure (hypotension)

• Reflex tachycardia

Rare but Serious: Syncope, severe hypotension, and worsening of angina if not used properly.

Precautions and Warnings

• Not for use in acute myocardial infarction without hemodynamic stability

• Avoid use with PDE5 inhibitors (e.g., Sildenafil, Tadalafil) due to risk of life-threatening hypotension

• Use cautiously in hypovolemia, glaucoma, or severe anemia

• Pregnancy Category C: Use only if clearly needed under physician advice

Drug Interactions

Avoid concurrent use with:

• Sildenafil, Tadalafil, Vardenafil

• Antihypertensive agents (monitor BP closely)

• Alcohol (enhances hypotensive effects)

FAQs about CARDULES ISDN 5 (Isosorbide Dinitrate 5 mg)

Q1. What is the main use of Isosorbide Dinitrate 5 mg?

A1. It is primarily used to prevent and treat angina pectoris (chest pain) by dilating blood vessels and improving oxygen supply to the heart.

Q2. Can Isosorbide Dinitrate 5 mg be used daily?

A2. Yes, it can be used daily, but it is essential to maintain a nitrate-free interval to avoid tolerance.

Q3. Is it safe to take CARDULES ISDN 5 with Sildenafil (Viagra)?

A3. No. Combining nitrates with Sildenafil can lead to dangerously low blood pressure.

Q4. What should I do if I miss a dose?

A4. Take it as soon as you remember. If it's close to your next dose, skip the missed dose. Do not double up.

Q5. How long does Isosorbide Dinitrate take to work?

A5. It usually starts working within 15–30 minutes when taken orally, but it’s primarily used prophylactically, not for acute attacks.

Conclusion

CARDULES ISDN 5 (Isosorbide Dinitrate 5 mg Tablet) is a reliable and clinically effective choice for long-term management of angina and heart failure support therapy. With proper usage and under the supervision of a healthcare provider, it offers significant cardiovascular protection and improved quality of life for patients with coronary artery disease.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

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