LINALIGLIP 2.5/500 Steris Healthcare PVT LTD.......

LINALIGLIP 2.5/500

Linagliptin & Metformin Hydrochloride

LINALIGLIP 2.5/500 is a combination medication used in the management of type 2 diabetes mellitus. This effective treatment pairs Linagliptin & Metformin Hydrochloride a biguanide, to control blood sugar levels in adults. This article provides an in-depth look into LINALIGLIP 2.5/500, covering its uses, dosage, side effects, composition, and more, ensuring a comprehensive understanding of this medication.

Composition

LINALIGLIP 2.5/500 contains two active ingredients:

• Linagliptin: 2.5 mg
• Metformin Hydrochloride: 500 mg

Mechanism of Action

Linagliptin works by inhibiting the enzyme dipeptidyl peptidase-4 (DPP-4). This inhibition increases the levels of incretin hormones, which help regulate glucose homeostasis by increasing insulin release and decreasing glucagon levels, particularly after meals.

Metformin Hydrochloride is a biguanide that lowers glucose production in the liver, decreases intestinal absorption of glucose, and improves insulin sensitivity by enhancing peripheral glucose uptake and utilization. Together, these mechanisms help maintain optimal blood sugar levels.

Uses

LINALIGLIP 2.5/500 is prescribed for:

• Management of type 2 diabetes mellitus
• Improving glycemic control in conjunction with diet and exercise
• Potentially reducing the risk of diabetes-related complications

Dosage and Administration

The dosage of LINALIGLIP 2.5/500 should be individualized based on the patient's current treatment regimen, effectiveness, and tolerability. Typically, the recommended starting dose is:

• Linagliptin: 2.5 mg twice daily
• Metformin Hydrochloride: 500 mg twice daily, gradually increased based on tolerance and efficacy

How to Take LINALIGLIP 2.5/500

• Take the medication orally with meals to minimize gastrointestinal side effects.
• Swallow the tablet whole; do not crush, chew, or break it.
• Maintain a consistent schedule to ensure stable blood sugar levels.

Side Effects

Like any medication, LINALIGLIP 2.5/500 may cause side effects. Common side effects include:

• Gastrointestinal disturbances (nausea, vomiting, diarrhea)
• Respiratory infections (nasopharyngitis, upper respiratory tract infections)
• Hypoglycemia (particularly when combined with other diabetes medications)
• Headache

Serious but rare side effects may include:

• Lactic acidosis (a serious metabolic complication associated with Metformin)
• Pancreatitis
• Allergic reactions (rash, hives, swelling)

Precautions and Warnings

• Renal Function: Monitor renal function before initiating treatment and periodically thereafter, as both components can affect kidney function.
• Hypersensitivity: Avoid use in patients with a known hypersensitivity to Linagliptin, Metformin, or any component of the formulation.
• Lactic Acidosis: Due to the risk associated with Metformin, caution is advised in patients with conditions predisposing them to lactic acidosis.
• Pancreatitis: Discontinue immediately if pancreatitis is suspected and do not restart.

Interactions

LINALIGLIP 2.5/500 can interact with several medications, potentially altering their effects. Some notable interactions include:

• Diuretics: May enhance the diuretic effect, increasing the risk of dehydration and hypotension.
• Insulin or Insulin Secretagogues: Increases the risk of hypoglycemia.
• Radiologic Studies with Contrast: Temporary discontinuation of Metformin is recommended to reduce the risk of lactic acidosis.
• Alcohol: Can potentiate the effect of Metformin on lactate metabolism, increasing the risk of lactic acidosis.

Monitoring

Regular monitoring is crucial to ensure the safe and effective use of LINALIGLIP 2.5/500:

• Blood Glucose Levels: Regular monitoring helps assess the efficacy of the medication.
• Renal Function: Periodic assessment of kidney function is necessary.
• HbA1c Levels: To evaluate long-term glycemic control.

Lifestyle and Dietary Recommendations

• Diet: Follow a balanced diet rich in fiber, low in refined sugars and saturated fats.
• Exercise: Regular physical activity helps improve insulin sensitivity and overall health.
• Hydration: Maintain adequate fluid intake to prevent dehydration.

Conclusion

LINALIGLIP 2.5/500, combining Linagliptin and Metformin Hydrochloride, offers an effective solution for managing type 2 diabetes mellitus. By understanding its uses, dosage, side effects, and precautions, patients can optimize their treatment and improve their quality of life. Always consult with a healthcare provider for personalized advice and monitoring while using this medication. This comprehensive guide to LINALIGLIP 2.5/500 aims to provide valuable information for patients and healthcare providers, helping them make informed decisions about diabetes management. Steris Healthcare Pvt Ltd, established in February 2018 by seasoned professionals in the pharmaceutical sector, operates under the name Sterispharma. Headquartered in Navi Mumbai, the company is certified by WHO, GMP, and ISO. Sterispharma is dedicated to providing high-quality medications at affordable prices across India, adhering to stringent WHO guidelines. They offer an online pharmacy platform for easy medicine purchases and home delivery. The company's mission is to deliver a diverse range of healthcare products catering to the varied needs of the medical community. From advanced treatments and rare condition medications to essential health supplies, Sterispharma aims to meet the extensive demands of the healthcare industry. Their product range covers numerous health fields, including Cardiology, Asthma, Respiratory issues, Nasal conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental care, and Dermatology.

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