LINALIGLIP DAPA 5-10 & Linagliptin (5mg) and Dapagliflozin (10mg) Tablet - Steris Healthcare PVT LTD…

Linagliptin 5 mg & Dapagliflozin 10 mg

LINALIGLIP DAPA 5-10

Linagliptin 5 mg & Dapagliflozin 10 mg combines LINALIGLIP DAPA 5-10 to provide an innovative treatment for Type 2 Diabetes Mellitus (T2DM). This dual-action medication leverages the complementary mechanisms of both drugs to enhance glycemic control, improve insulin sensitivity, and promote overall metabolic health. Ideal for patients seeking a comprehensive approach to diabetes management, LINALIGLIP DAPA 5-10 simplifies the treatment regimen while maximizing efficacy.

Composition

Linagliptin (5mg): A DPP-4 inhibitor that increases insulin secretion and decreases glucagon levels in a glucose-dependent manner.
Dapagliflozin (10mg): An SGLT2 inhibitor that increases glucose excretion through urine.

Mechanism of Action

Linagliptin

Linagliptin works by inhibiting the enzyme dipeptidyl peptidase-4 (DPP-4), which leads to increased levels of incretin hormones. These hormones help regulate glucose by increasing insulin synthesis and release from pancreatic beta cells while decreasing the secretion of glucagon from alpha cells. This results in improved blood sugar levels and overall glycemic control.

Dapagliflozin

Dapagliflozin inhibits the sodium-glucose co-transporter 2 (SGLT2) in the kidneys, reducing glucose reabsorption and increasing its excretion through urine. This unique mechanism helps lower blood glucose levels independently of insulin, providing an additional pathway to manage hyperglycemia.

Indications

LINALIGLIP DAPA 5-10 is indicated for the treatment of Type 2 Diabetes Mellitus in adults. It is particularly beneficial for patients who:

• Have not achieved adequate glycemic control with diet and exercise alone.
• Require combination therapy to maintain optimal blood sugar levels.
• Are transitioning from monotherapy to a more effective dual therapy.

Dosage and Administration

Initial Dose

• One tablet of LINALIGLIP DAPA 5-10 (Linagliptin 5mg, Dapagliflozin 10mg) taken once daily, preferably in the morning, with or without food.

Maintenance Dose

• The dosage may be adjusted based on the patient's response and tolerance. Regular monitoring of blood glucose levels is essential to tailor the treatment to individual needs.

Benefits of LINALIGLIP DAPA 5-10

1. Enhanced Glycemic Control: The combination of Linagliptin and Dapagliflozin provides a synergistic effect, leading to better management of blood sugar levels.
2. Weight Management: Dapagliflozin promotes weight loss due to the calorie loss associated with glucose excretion.
3. Cardiovascular Benefits: Dapagliflozin has been shown to reduce systolic blood pressure and provide cardiovascular protection.
4. Reduced Risk of Hypoglycemia: The glucose-dependent action of Linagliptin and the unique mechanism of Dapagliflozin minimize the risk of hypoglycemia.
5. Improved Patient Compliance: Combining two effective medications into a single tablet simplifies the treatment regimen.

Potential Side Effects

Common Side Effects

• Linagliptin: Nasopharyngitis, headache, cough.
• Dapagliflozin: Genital infections, urinary tract infections, increased urination, dehydration.

Serious Side Effects

• Ketoacidosis: Though rare, Dapagliflozin may cause diabetic ketoacidosis (DKA) even with normal blood sugar levels. Symptoms include nausea, vomiting, abdominal pain, and difficulty breathing.
• Pancreatitis: Though rare, Linagliptin may cause pancreatitis. Symptoms include severe abdominal pain, nausea, and vomiting.
• Hypotension: Due to its diuretic effect, Dapagliflozin can cause a significant drop in blood pressure, leading to dizziness or fainting.

Precautions and Warnings

1. Renal Impairment: Regular monitoring of renal function is necessary, as Dapagliflozin is contraindicated in severe renal impairment.
2. Volume Depletion: Monitor for signs of dehydration, especially in patients on diuretics or those with low blood pressure.
3. Elderly Patients: Use with caution in elderly patients who are at higher risk of volume depletion and renal function decline.
4. Pregnancy and Lactation: Consult a healthcare provider, as the safety of this combination in pregnant or breastfeeding women is not well established.
5. Pancreatitis: Patients should be monitored for signs and symptoms of pancreatitis and discontinue Linagliptin if pancreatitis is suspected.

Drug Interactions

• Diuretics: Enhanced diuretic effect can increase the risk of dehydration and hypotension.
• Insulin and Insulin Secretagogues: Combination with these agents can increase the risk of hypoglycemia.
• Rifampicin: May reduce the efficacy of Linagliptin by increasing its metabolism.
• Cimetidine: May increase the effects of Linagliptin by reducing its renal clearance.

Monitoring Parameters

1. Blood Glucose Levels: Regular self-monitoring to ensure adequate glycemic control.
2. HbA1c Levels: Periodic testing to assess long-term glycemic control.
3. Renal Function: Regular monitoring, especially in patients with pre-existing renal conditions.
4. Signs of Pancreatitis: Monitor for symptoms such as severe abdominal pain, nausea, and vomiting.
5. Electrolyte Levels: Monitor for imbalances, particularly in patients on diuretics.

Conclusion

LINALIGLIP DAPA 5-10, combining Linagliptin (5mg) and Dapagliflozin (10mg), offers a comprehensive solution for managing Type 2 Diabetes Mellitus. This medication not only improves glycemic control but also provides additional benefits such as weight loss, cardiovascular protection, and improved patient compliance. As always, it is essential to consult a healthcare provider to determine if LINALIGLIP DAPA 5-10 is the right choice for your diabetes management plan. Regular monitoring and adherence to prescribed dosages will help maximize the therapeutic benefits while minimizing potential risks.Steris Healthcare Pvt Ltd, established in February 2018 by seasoned professionals in the pharmaceutical sector, operates under the name Sterispharma. Headquartered in Navi Mumbai, the company is certified by WHO, GMP, and ISO. Sterispharma is dedicated to providing high-quality medications at affordable prices across India, adhering to stringent WHO guidelines. They offer an online pharmacy platform for easy medicine purchases and home delivery. The company's mission is to deliver a diverse range of healthcare products catering to the varied needs of the medical community. From advanced treatments and rare condition medications to essential health supplies, Sterispharma aims to meet the extensive demands of the healthcare industry. Their product range covers numerous health fields, including Cardiology, Asthma, Respiratory issues, Nasal conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental care, and Dermatology.

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