LINALIGLIP M 5/500 & Linagliptin 5mg and Metformin Hydrochloride (SR) 500mg Tablet - Steris Healthcare PVT LTD..

Linagliptin 5mg and Metformin Hydrochloride (SR) 500mg

LINALIGLIP M 5/500

Linagliptin 5mg and Metformin Hydrochloride (SR) 500mg combines LINALIGLIP M 5/500 to provide an effective treatment for Type 2 Diabetes Mellitus (T2DM). This combination therapy leverages the complementary mechanisms of both drugs to improve glycemic control, reduce HbA1c levels, and manage overall diabetes health. Ideal for patients who need a comprehensive and convenient approach to diabetes management, LINALIGLIP M 5/500 simplifies the treatment regimen while enhancing efficacy.

Composition

Linagliptin (5mg): A DPP-4 inhibitor that increases insulin secretion and decreases glucagon levels in a glucose-dependent manner.
Metformin Hydrochloride (SR) (500mg): A biguanide that decreases hepatic glucose production and improves insulin sensitivity.

Mechanism of Action

Linagliptin

Linagliptin inhibits the enzyme dipeptidyl peptidase-4 (DPP-4), which results in increased levels of incretin hormones. These hormones help regulate glucose by increasing insulin synthesis and release from pancreatic beta cells and decreasing the secretion of glucagon from alpha cells. This leads to reduced hepatic glucose production and improved glycemic control.

Metformin Hydrochloride (SR)

Metformin Hydrochloride (Sustained Release) primarily works by inhibiting hepatic gluconeogenesis, thereby reducing the amount of glucose produced by the liver. Additionally, it enhances insulin sensitivity in peripheral tissues, promoting better glucose uptake by muscles and fat cells. The sustained-release formulation ensures a gradual release of the medication, minimizing gastrointestinal side effects and improving patient compliance.

Indications

LINALIGLIP M 5/500 is indicated for the treatment of Type 2 Diabetes Mellitus in adults. It is particularly beneficial for patients who:

• Have not achieved adequate glycemic control with diet and exercise alone.
• Require combination therapy to maintain optimal blood sugar levels.
• Are transitioning from monotherapy to a more robust dual therapy.

Dosage and Administration

Initial Dose

• One tablet of LINALIGLIP M 5/500 (Linagliptin 5mg, Metformin Hydrochloride SR 500mg) taken once daily, preferably with a meal to enhance absorption and reduce gastrointestinal side effects.

Maintenance Dose

• The dosage may be adjusted based on the patient's response and tolerance. Regular monitoring of blood glucose levels is essential to tailor the treatment to individual needs.

Benefits of LINALIGLIP M 5/500

1. Enhanced Glycemic Control: The combination of Linagliptin and Metformin SR provides a synergistic effect, leading to better management of blood sugar levels.
2. Reduced HbA1c Levels: Effective in lowering HbA1c levels, improving long-term glycemic control.
3. Weight Neutrality: Linagliptin is weight-neutral, making it suitable for patients concerned about weight gain.
4. Improved Compliance: Combining two effective medications into a single tablet simplifies the treatment regimen.
5. Reduced Risk of Hypoglycemia: The glucose-dependent action of Linagliptin and the weight-neutral effect of Metformin minimize the risk of hypoglycemia.

Potential Side Effects

Common Side Effects

• Linagliptin: Nasopharyngitis, headache, cough.
• Metformin SR: Gastrointestinal issues such as diarrhea, nausea, vomiting, and abdominal discomfort.

Serious Side Effects

• Lactic Acidosis: A rare but serious side effect of Metformin characterized by muscle pain, difficulty breathing, abdominal pain, and fatigue. Patients with renal impairment or conditions predisposing them to hypoxia are at higher risk.
• Pancreatitis: Though rare, Linagliptin may cause pancreatitis. Symptoms include severe abdominal pain, nausea, and vomiting.

Precautions and Warnings

1. Renal Impairment: Regular monitoring of renal function is necessary, as Metformin is contraindicated in severe renal impairment.
2. Hepatic Impairment: Use with caution in patients with liver disease.
3. Alcohol Consumption: Limit alcohol intake due to the increased risk of lactic acidosis with Metformin.
4. Pregnancy and Lactation: Consult a healthcare provider, as the safety of this combination in pregnant or breastfeeding women is not well established.

Drug Interactions

• Diuretics: Enhanced diuretic effect can increase the risk of dehydration and hypotension.
• Insulin and Insulin Secretagogues: Combination with these agents can increase the risk of hypoglycemia.
• Cimetidine: May increase the effects of Metformin by reducing its renal clearance.
• Rifampicin: May reduce the efficacy of Linagliptin by increasing its metabolism.

Monitoring Parameters

1. Blood Glucose Levels: Regular self-monitoring to ensure adequate glycemic control.
2. HbA1c Levels: Periodic testing to assess long-term glycemic control.
3. Renal Function: Regular monitoring, especially in patients with pre-existing renal conditions.
4. Liver Function Tests: Periodic testing to ensure hepatic safety.

Conclusion

LINALIGLIP M 5/500, combining Linagliptin (5mg) and Metformin Hydrochloride (SR) (500mg), offers a comprehensive solution for managing Type 2 Diabetes Mellitus. This medication not only improves glycemic control but also provides additional benefits such as weight neutrality and enhanced patient compliance. As always, it is essential to consult a healthcare provider to determine if LINALIGLIP M 5/500 is the right choice for your diabetes management plan. Regular monitoring and adherence to prescribed dosages will help maximize the therapeutic benefits while minimizing potential risks.Steris Healthcare Pvt Ltd, established in February 2018 by seasoned professionals in the pharmaceutical sector, operates under the name Sterispharma. Headquartered in Navi Mumbai, the company is certified by WHO, GMP, and ISO. Sterispharma is dedicated to providing high-quality medications at affordable prices across India, adhering to stringent WHO guidelines. They offer an online pharmacy platform for easy medicine purchases and home delivery. The company's mission is to deliver a diverse range of healthcare products catering to the varied needs of the medical community. From advanced treatments and rare condition medications to essential health supplies, Sterispharma aims to meet the extensive demands of the healthcare industry. Their product range covers numerous health fields, including Cardiology, Asthma, Respiratory issues, Nasal conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental care, and Dermatology.

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