Mesalamine (800mg) '''

MESALMILE 800 ER 

Mesalamine (800mg)

Mesalmile, also known as mesalazine, is a medication commonly prescribed to treat inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn’s disease. It belongs to a class of drugs called aminosalicylates, which work by reducing inflammation in the lining of the intestines. The 800 mg extended-release (ER) version, marketed under several brand names, provides a convenient way to manage the symptoms of these chronic conditions by allowing for less frequent dosing.

In this comprehensive article, we will cover mesalamine 800 mg, its uses, dosage, potential side effects, and key considerations. This article will be especially useful for patients, caregivers, or healthcare providers seeking detailed information about mesalamine.

Uses of Mesalamine (800mg)

Mesalamine is primarily used for treating and managing mild to moderate cases of ulcerative colitis, an inflammatory condition that affects the lining of the colon and rectum. It can also be used for maintenance therapy to prevent relapses. Mesalamine helps to reduce symptoms such as diarrhea, rectal bleeding, stomach pain, and urgency to have a bowel movement.

Although mesalamine is most commonly associated with ulcerative colitis, it may also be prescribed for Crohn’s disease, particularly when inflammation is confined to the colon. The extended-release formulation ensures that the medication is released slowly over time, providing prolonged therapeutic effects, which can reduce the frequency of dosage.

Key Uses:

• Ulcerative colitis treatment: To reduce active inflammation in the colon.
• Maintenance of remission: To prevent flare-ups and keep the disease under control.
• Crohn’s disease: In certain cases, especially when the colon is primarily involved.

Mesalamine does not cure these diseases but is instrumental in reducing inflammation, thereby allowing the intestinal tissues to heal and providing relief from symptoms.

Dosage of Mesalamine (800mg ER)

The dosage of mesalamine depends on the severity of the condition, the patient’s age, weight, and response to the treatment. It’s essential to follow the prescribed dosage regimen given by a healthcare professional.

Standard Dosage Guidelines:

• For the treatment of active ulcerative colitis: The typical adult dose is two 800 mg tablets, taken three times daily. This amounts to a total daily dosage of 4.8 grams, which is divided into three doses throughout the day. This dosage is often used for the initial 6-8 weeks of treatment to bring the disease under control.

• For maintenance of remission: Once the symptoms are under control, the maintenance dose is usually two 800 mg tablets, taken once or twice daily. The goal of the maintenance dose is to keep the disease in remission and prevent flare-ups.

• For pediatric use: The dosing for children depends on body weight and must be determined by a pediatric gastroenterologist. Dosages are adjusted based on the child’s needs, but extended-release forms are typically used with caution in younger patients.

Mesalamine 800 mg ER tablets are to be swallowed whole, and patients should not crush or chew them, as this can interfere with the extended-release mechanism. It is also recommended to take the tablets with a full glass of water to help with absorption.

Side Effects of Mesalamine (800mg)

Like any medication, mesalamine can cause side effects, though not everyone will experience them. Most side effects are mild and tend to subside over time as the body adjusts to the medication. However, there are also more serious side effects that patients should be aware of.

Common Side Effects:

• Headache: This is one of the most commonly reported side effects. Drinking plenty of water and resting may help alleviate mild headaches.
• Nausea and vomiting: Some patients may experience mild gastrointestinal upset.
• Diarrhea or constipation: Mesalamine is intended to regulate bowel movements, but in some cases, it can cause diarrhea or constipation.
• Dizziness: A sense of dizziness may occur, particularly when standing up quickly.
• Abdominal pain: Some individuals may experience cramping or pain in the abdomen as their body adjusts to the medication.

Rare but Serious Side Effects:

• Kidney problems: Mesalamine has been associated with a risk of kidney dysfunction, including interstitial nephritis. Regular kidney function tests may be required during long-term therapy.
• Pancreatitis: In rare cases, mesalamine can cause inflammation of the pancreas (pancreatitis), which presents as severe abdominal pain, nausea, and vomiting.
• Liver toxicity: Patients with liver disease should use mesalamine cautiously, as it can affect liver function.
• Blood disorders: Some people may develop blood-related conditions like anemia or low white blood cell count, which can increase the risk of infection.
• Allergic reactions: Although rare, some individuals may experience severe allergic reactions to mesalamine, including rash, itching, swelling (especially of the face or throat), and difficulty breathing.

Patients should contact their healthcare provider if they experience any unusual or severe symptoms while taking mesalamine. It's important to differentiate between side effects and symptoms of worsening disease, which could require a different treatment approach.

Important Considerations

While mesalamine is generally well-tolerated, there are certain precautions to keep in mind:

• Allergies: Mesalamine is contraindicated in individuals who are allergic to salicylates (e.g., aspirin) or any components of the drug. If a patient has a known sensitivity to these, alternative therapies should be considered.
• Kidney and liver monitoring: Regular blood tests to check kidney and liver function may be necessary during long-term treatment, as mesalamine can affect these organs.
• Pregnancy and breastfeeding: While mesalamine is generally considered safe for use during pregnancy, it should be used only if clearly needed. Pregnant women should consult their doctor before starting treatment. Breastfeeding women should also discuss the potential risks and benefits with their healthcare provider.
• Drug interactions: Mesalamine can interact with other medications, particularly nonsteroidal anti-inflammatory drugs (NSAIDs) and certain immune-modulating drugs. Always inform the healthcare provider of all medications and supplements being taken.

Conclusion

Mesalamine 800 mg ER is an effective treatment for managing the symptoms of ulcerative colitis and maintaining remission. Its ability to reduce inflammation in the intestines helps prevent flare-ups, providing relief for many patients living with inflammatory bowel diseases. Although mesalamine is generally well-tolerated, it is essential to be aware of the potential side effects and to use the medication under the guidance of a healthcare professional. Steris Healthcare Pvt Ltd, operating as Sterispharma since its founding by expert professionals in the pharmaceutical industry in February 2018, is based in Navi Mumbai. The company is certified by WHO, GMP, and ISO, emphasizing its commitment to quality and safety. Sterispharma focuses on providing high-quality drugs at affordable prices throughout India, adhering strictly to WHO guidelines. Offering the convenience of an online pharmacy, customers can easily purchase medicines with home delivery options available. Sterispharma's mission is to supply a broad range of healthcare products to meet the diverse needs of the medical community. From advanced treatments and medications for rare conditions to essential health necessities, Sterispharma aims to serve the extensive demands of the healthcare industry. You can order medicines from Sterispharma through their websites, sterisonline and sterispharma. Their extensive product lineup includes treatments for Cardiology, Asthma, Respiratory Issues, Nasal Conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/Antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental Care, and Dermatology.

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