Mesalamine (800mg) & MESALMILE 800 ER :Tablet - Steris Healthcare PVT LTD………

Mesalamine (800mg) & MESALMILE 800 ER 

 Mesalamine ( 800mg ), also known as mesalazine, is a widely used anti-inflammatory medication for treating inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn's disease. MESALMILE 800 ER is a specific extended-release formulation of mesalamine, offering a higher dose for effective management of these chronic conditions. This comprehensive guide will explore the uses, benefits, dosage, potential side effects, and other critical aspects of MESALMILE 800 ER.

What is Mesalamine?

Mesalamine is a 5-aminosalicylic acid (5-ASA) derivative that acts locally in the gut to reduce inflammation. It is particularly effective in treating and managing conditions characterized by chronic inflammation of the gastrointestinal tract. Mesalamine's primary mechanism involves inhibiting the production of inflammatory chemicals and modulating the immune response in the gut.

MESALMILE 800 ER: Overview

MESALMILE 800 ER is an extended-release formulation that provides a sustained release of mesalamine throughout the gastrointestinal tract. This higher-dose formulation is designed to offer prolonged therapeutic effects, making it suitable for patients who require consistent drug levels to manage their symptoms effectively.

Key Features of MESALMILE 800 ER

• Extended-Release Formulation: Ensures a steady release of medication over an extended period.
• High Dose: Contains 800mg of mesalamine per tablet, suitable for patients with more severe symptoms or those who require higher maintenance doses.
• Convenient Dosing: Typically taken once or twice daily, improving patient adherence and convenience.

Uses of MESALMILE 800 ER

Ulcerative Colitis

Ulcerative colitis is a chronic condition characterized by inflammation and ulceration of the colon and rectum. MESALMILE 800 ER is commonly prescribed for:

• Inducing Remission: Helping to reduce the severity of active flare-ups.
• Maintaining Remission: Preventing the recurrence of symptoms and maintaining long-term control of the disease.
• Symptom Management: Reducing symptoms such as abdominal pain, diarrhea, and rectal bleeding.

Mechanism of Action

Mesalamine works through several mechanisms to reduce inflammation in the gut:

• Inhibition of Cyclooxygenase and Lipoxygenase Pathways: Reduces the production of prostaglandins and leukotrienes, which are inflammatory mediators.
• Scavenging Free Radicals: Mesalamine acts as an antioxidant, neutralizing free radicals that contribute to inflammation.
• Inhibition of NF-κB Activation: Reduces the activation of nuclear factor kappa B (NF-κB), a protein complex involved in the inflammatory response.

Dosage and Administration

The dosage of MESALMILE 800 ER should be determined by a healthcare provider based on the patient's condition and response to treatment. Common dosing guidelines include:

• Initial Treatment: Often involves higher doses to quickly reduce inflammation and induce remission.
• Maintenance Therapy: Lower, sustained doses to maintain remission and prevent flare-ups.

Typical Dosing Schedule

• Inducing Remission: 800mg (one tablet) taken twice daily.
• Maintaining Remission: 800mg taken once or twice daily, depending on individual patient needs and response.

Benefits of MESALMILE 800 ER

Effective Symptom Control

MESALMILE 800 ER is highly effective in controlling the symptoms of IBD, including abdominal pain, diarrhea, and rectal bleeding. It helps improve the quality of life for patients by reducing the frequency and severity of flare-ups.

Maintenance of Remission

Regular use of MESALMILE 800 ER helps maintain remission in patients with ulcerative colitis, reducing the risk of complications and the need for corticosteroids or other immunosuppressive therapies.

Convenient Dosing

The extended-release formulation of MESALMILE 800 ER allows for less frequent dosing, enhancing patient adherence and convenience. This is particularly beneficial for patients who struggle with multiple daily doses.

Potential Side Effects

While mesalamine is generally well-tolerated, some patients may experience side effects, including:

• Gastrointestinal Issues: Nausea, abdominal pain, diarrhea, and flatulence.
• Headache: A common side effect reported by some patients.
• Skin Reactions: Rash or itching.
• Rare Side Effects: Kidney or liver dysfunction, pancreatitis, and myocarditis.

Special Considerations

Kidney Function

Mesalamine can affect kidney function, especially in patients with pre-existing kidney conditions. Regular monitoring of kidney function is recommended during treatment with MESALMILE 800 ER.

Liver Function

Patients with liver disease should use mesalamine with caution, and liver function tests may be necessary to monitor for potential issues.

Allergies

Patients with known allergies to salicylates or any components of MESALMILE 800 ER should avoid this medication.

Drug Interactions

Mesalamine may interact with other medications, which could affect its efficacy or increase the risk of side effects. Notable interactions include:

• Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Increased risk of kidney issues.
• Azathioprine and 6-Mercaptopurine: Increased risk of blood disorders.

It is crucial to inform the healthcare provider of all medications and supplements being taken to avoid potential interactions.

Patient Experience and Adherence

Adherence to medication is critical for achieving optimal outcomes in IBD management. The extended-release formulation of MESALMILE 800 ER improves adherence by reducing the number of doses needed per day, thus enhancing convenience for patients.

Tips for Improving Adherence

• Incorporate into Routine: Take MESALMILE 800 ER at the same time each day to build a habit.
• Education: Understand the importance of medication adherence and the role of MESALMILE 800 ER in managing your condition.

Conclusion

MESALMILE 800 ER is a valuable treatment option for managing inflammatory bowel diseases, particularly ulcerative colitis. Its extended-release formulation provides effective symptom control, maintenance of remission, and a favorable safety profile. By understanding the benefits, potential side effects, and special considerations associated with MESALMILE 800 ER, patients can make informed decisions about their treatment and take proactive steps toward managing their condition effectively. Steris Healthcare Pvt Ltd, established in February 2018 by seasoned professionals in the pharmaceutical sector, operates under the name Sterispharma. Headquartered in Navi Mumbai, the company is certified by WHO, GMP, and ISO. Sterispharma is dedicated to providing high-quality medications at affordable prices across India, adhering to stringent WHO guidelines. They offer an online pharmacy platform for easy medicine purchases and home delivery. The company's mission is to deliver a diverse range of healthcare products catering to the varied needs of the medical community. From advanced treatments and rare condition medications to essential health supplies, Sterispharma aims to meet the extensive demands of the healthcare industry. Their product range covers numerous health fields, including Cardiology, Asthma, Respiratory issues, Nasal conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental care, and Dermatology.

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