Montelukast (10mg), Levocetirizine (5mg)..

Montelukast (10mg), Levocetirizine (5mg)
MONTELUKE LC

Monteluke LC is a widely used medication primarily prescribed to treat allergies and respiratory conditions, especially in cases where both allergy symptoms and respiratory complications coexist. It contains two main active ingredients, Montelukast (10 mg) and Levocetirizine (5 mg), each offering distinct benefits that together make Monteluke LC a potent combination for managing symptoms like sneezing, itching, runny nose, and breathing difficulties.

Understanding the Composition

1. Montelukast (10 mg): Montelukast is a leukotriene receptor antagonist (LTRA) that works by blocking the action of leukotrienes. Leukotrienes are chemicals released by the immune system in response to allergens, and they cause inflammation, swelling, and constriction in the airways. Montelukast’s primary role is to prevent these symptoms, thus easing breathing and reducing inflammation, especially in conditions like asthma and allergic rhinitis.

2. Levocetirizine (5 mg): Levocetirizine is a second-generation antihistamine that works by inhibiting histamine, another chemical responsible for allergic reactions. Histamines trigger symptoms like itching, sneezing, and watery eyes. Levocetirizine effectively blocks these symptoms, offering fast relief without the heavy sedation or drowsiness associated with first-generation antihistamines.

Together, Montelukast and Levocetirizine in Monteluke LC provide comprehensive allergy and asthma management, combining the benefits of an anti-inflammatory with a potent antihistamine.

Mechanism of Action

• Montelukast: By binding to leukotriene receptors in the lungs and airways, Montelukast prevents leukotriene action, thereby reducing inflammation and opening airways. This makes it effective in treating asthma and preventing exercise-induced bronchoconstriction.

• Levocetirizine: Levocetirizine selectively inhibits histamine H1 receptors, countering the body’s histamine response without crossing into the brain's central nervous system significantly. As a result, it provides relief from allergic symptoms with minimal side effects.

Uses and Benefits

Monteluke LC is primarily indicated for:

1. Allergic Rhinitis: Seasonal or perennial allergic rhinitis symptoms such as sneezing, nasal congestion, itchy eyes, and throat irritation are alleviated due to the combined action of Levocetirizine and Montelukast.

2. Asthma: Montelukast helps control asthma symptoms, such as wheezing, shortness of breath, and cough. This makes it an ideal adjunct therapy in patients with mild to moderate asthma, particularly when asthma is triggered by allergies.

3. Chronic Urticaria (Hives): Levocetirizine helps in reducing the symptoms of hives, including itching, redness, and swelling.

4. Exercise-Induced Bronchoconstriction: Montelukast helps in preventing bronchoconstriction associated with physical exertion, making it beneficial for patients who experience breathing difficulties during exercise.

Dosage and Administration

Monteluke LC is generally prescribed as a once-daily oral tablet. The typical dosage contains Montelukast 10 mg and Levocetirizine 5 mg, which are generally well tolerated. However, the exact dosage and duration should be determined by a healthcare provider, based on individual needs and severity of symptoms.

Special Dosage Considerations:

• For adults and adolescents over 15 years: The usual recommended dose is one tablet taken in the evening.
• For children under 15 years: Monteluke LC may be prescribed in different formulations, depending on age and weight. Pediatricians should be consulted for proper dosing.

Potential Side Effects

While Monteluke LC is considered safe, some patients may experience mild to moderate side effects. Common side effects include:

• Drowsiness (mostly from Levocetirizine)
• Headache
• Dry Mouth
• Fatigue
• Abdominal Pain

In rare cases, Montelukast has been associated with neuropsychiatric effects, such as mood changes, agitation, or depression, particularly in sensitive individuals. Patients should be monitored, especially when starting therapy or adjusting dosages.

Precautions and Contraindications

1. Pregnancy and Breastfeeding: Monteluke LC should be used cautiously during pregnancy and breastfeeding. Though generally considered safe, the risks versus benefits should be thoroughly assessed by a healthcare provider.

2. Kidney or Liver Impairments: Patients with significant kidney or liver issues should use Monteluke LC cautiously, as dosage adjustments may be necessary.

3. Known Hypersensitivity: Anyone with a known allergy to Montelukast, Levocetirizine, or any inactive ingredients should avoid this medication.

Monteluke LC vs. Traditional Treatments

Monteluke LC’s dual-action approach offers a significant advantage over single-drug therapies in managing allergic rhinitis and asthma together. Many patients experience more complete symptom relief with fewer medications when taking this combination. Additionally, its once-daily dosing offers convenience compared to first-generation antihistamines and bronchodilators that may require multiple doses throughout the day.

Drug Interactions

1. Alcohol and Sedatives: Combining Levocetirizine with alcohol or other sedative drugs can enhance drowsiness and impair motor skills.
2. Other Antihistamines or Anti-Allergic Drugs: Patients should avoid taking other antihistamines or allergy medications alongside Monteluke LC unless advised by a doctor.
3. Enzyme Inducers: Some drugs that induce liver enzymes, like certain anticonvulsants, may reduce the effectiveness of Montelukast.

Conclusion:

Monteluke LC, with its combination of Montelukast and Levocetirizine, offers a balanced solution for those with respiratory allergies, allergic rhinitis, and mild asthma. Its dual approach effectively targets both the histamine and leukotriene pathways, providing comprehensive relief from a wide range of allergy and respiratory symptoms. Always consult with a healthcare provider for personalized guidance on dosage, duration, and to understand any specific precautions before beginning treatment. Steris Healthcare Pvt Ltd, operating as Sterispharma since its founding by expert professionals in the pharmaceutical industry in February 2018, is based in Navi Mumbai. The company is certified by WHO, GMP, and ISO, emphasizing its commitment to quality and safety. Sterispharma focuses on providing high-quality drugs at affordable prices throughout India, adhering strictly to WHO guidelines. Offering the convenience of an online pharmacy, customers can easily purchase medicines with home delivery options available. Sterispharma's mission is to supply a broad range of healthcare products to meet the diverse needs of the medical community. From advanced treatments and medications for rare conditions to essential health necessities, Sterispharma aims to serve the extensive demands of the healthcare industry. You can order medicines from Sterispharma through their websites, Sterisonline  ,  Sterisindia and Sterispharma. Their extensive product lineup includes treatments for Cardiology, Asthma, Respiratory Issues, Nasal Conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/Antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental Care, and Dermatology. 

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