Naproxen 500 mg + Domperidone SR 30 mg

Naproxzen D 500: Naproxen (500mg), Domperidone SR (30mg) – Complete Guide

Naproxzen D 500 is a combination medication that contains naproxen (500mg), a potent NSAID (Non-Steroidal Anti-Inflammatory Drug), and domperidone SR (30mg), a gastrointestinal motility agent. This combination is formulated to provide pain relief, anti-inflammatory benefits, and improve gastrointestinal function for individuals suffering from a variety of conditions such as arthritis, pain, nausea, and vomiting.

What is Naproxzen D 500?

Naproxzen D 500 combines two key active ingredients:

1. Naproxen (500mg): A nonsteroidal anti-inflammatory drug (NSAID) that works by reducing inflammation, pain, and fever.
2. Domperidone SR (30mg): A gastrointestinal motility agent that helps relieve nausea, vomiting, and improves gastric motility (the movement of food through the stomach).

The SR (Sustained Release) formulation of domperidone ensures that it is released slowly over time, providing prolonged effects without frequent dosing.

Key Features and Ingredients

1. Naproxen (500mg):

   • Pain Relief: Naproxen is highly effective for the treatment of mild to moderate pain, including musculoskeletal pain, arthritis, and dysmenorrhea (painful menstruation).
   • Anti-inflammatory: Naproxen reduces inflammation by inhibiting the production of prostaglandins, which are compounds that promote inflammation, pain, and fever.
   • Fever Reduction: It also works as an antipyretic, helping to reduce fever caused by infections or inflammatory conditions.

2. Domperidone SR (30mg):

   • Gastrointestinal Motility: Domperidone SR enhances gastric motility, helping to improve stomach emptying. It is particularly useful for individuals suffering from gastroparesis, a condition that causes delayed stomach emptying.
   • Nausea and Vomiting Relief: Domperidone SR works by blocking dopamine receptors in the brain and gastrointestinal tract, preventing nausea and vomiting caused by various factors, including medication side effects or gastrointestinal disorders.
   • Sustained Release: The SR formulation ensures consistent effects throughout the day with a gradual release of domperidone, leading to sustained therapeutic benefits.

Uses of Naproxzen D 500

1. Pain Relief:

   • Naproxzen D 500 is used to provide effective relief for various types of pain, including musculoskeletal pain, arthritis pain, back pain, gout, and menstrual pain (dysmenorrhea). Naproxen (500mg) works by reducing pain and inflammation in the affected areas.

2. Inflammation:

   • The anti-inflammatory properties of naproxen help to reduce swelling and inflammation in conditions like osteoarthritis, rheumatoid arthritis, and gout. Naproxzen D 500 is beneficial for both acute and chronic inflammation.

3. Fever Reduction:

   • As an antipyretic, naproxen helps in reducing fever caused by infections or inflammatory conditions, bringing comfort to individuals experiencing high body temperature.

4. Gastrointestinal Disorders:

   • The domperidone SR (30mg) component in Naproxzen D 500 helps to treat symptoms such as nausea, vomiting, and gastroparesis by improving the motility of the stomach. It aids in accelerating gastric emptying, which helps to alleviate discomfort caused by delayed digestion.

5. Adjunct Therapy:

   • Naproxzen D 500 can also be used as an adjunct in the management of conditions that require both pain relief and gastric motility improvement, such as post-operative care or medication-induced nausea.

How Does Naproxzen D 500 Work?

1. Naproxen:

   • Naproxen (500mg) works by inhibiting the COX-1 and COX-2 enzymes, which are responsible for the production of prostaglandins—chemicals that promote inflammation, pain, and fever. By blocking these enzymes, naproxen reduces the production of prostaglandins, leading to a decrease in pain, swelling, and fever.

2. Domperidone SR:

   • Domperidone SR works by blocking dopamine receptors in the gastrointestinal system and the brain's vomiting center. This action increases gastric motility, helping the stomach empty more quickly and effectively. It also reduces nausea and vomiting, providing relief for individuals suffering from gastrointestinal discomfort.

Benefits of Naproxzen D 500

1. Effective Pain and Inflammation Relief:

   • Naproxzen D 500 is highly effective in managing acute and chronic pain. The combination of naproxen and domperidone provides comprehensive relief from both pain and gastric discomfort.

2. Improved Gastrointestinal Function:

   • The domperidone SR (30mg) component improves gastric motility, which is particularly helpful for those suffering from gastroparesis or other gastrointestinal conditions that cause delayed stomach emptying. This makes Naproxzen D 500 an effective solution for managing nausea and vomiting.

3. Fever Reduction:

   • The antipyretic action of naproxen in Naproxzen D 500 helps to bring down fever, providing relief from discomfort associated with infections or inflammation.

4. Convenient Sustained-Release Formulation:

   • The SR formulation of domperidone ensures that the medication is released gradually over time, offering consistent therapeutic effects without the need for frequent dosing.

5. Dual Action for Pain and Gastrointestinal Symptoms:

   • Naproxzen D 500 combines the benefits of pain relief from naproxen with gastric motility improvement from domperidone, making it ideal for individuals who require treatment for both pain and gastrointestinal symptoms.

How to Use Naproxzen D 500

• Dosage: The typical dosage for Naproxzen D 500 is one tablet taken once or twice a day, depending on the severity of symptoms and your doctor’s recommendation. It’s important to follow the prescribed dosage to avoid any adverse effects.

• Administration: Naproxzen D 500 should be taken with food or milk to minimize the risk of gastric irritation. Swallow the tablet whole with a full glass of water. Do not chew or crush the tablet, as it may affect the sustained-release action of domperidone.

• Duration: The duration of treatment with Naproxzen D 500 depends on the condition being treated and your doctor’s advice. It is typically used for short-term pain management, but for chronic conditions, long-term use may be necessary under medical supervision.

Possible Side Effects of Naproxzen D 500

While Naproxzen D 500 is generally well tolerated, some individuals may experience side effects. These can include:

1. Gastrointestinal Issues:

   • Nausea, vomiting, abdominal discomfort, or heartburn may occur due to the NSAID (naproxen) component.

2. Headache or Dizziness:

   • Some individuals may experience a headache or dizziness due to the domperidone component.

3. Drowsiness:

   • Domperidone SR may cause drowsiness or sedation, so it is advisable to avoid operating heavy machinery or driving if you feel drowsy.

4. Allergic Reactions:

   • In rare cases, individuals may experience allergic reactions, such as skin rashes, swelling, or breathing difficulties. Seek immediate medical attention if any of these occur.

5. Gastrointestinal Bleeding or Ulcers:

   • Long-term use of naproxen may increase the risk of gastrointestinal bleeding, ulcers, or perforation. It is important to use this medication under medical supervision for prolonged periods.

6. Kidney or Liver Issues:

   • Long-term use of naproxen can potentially cause kidney or liver problems. Regular monitoring of kidney and liver function may be recommended during prolonged use.

Precautions and Warnings

• Pregnancy and Breastfeeding: Naproxzen D 500 should be avoided during pregnancy, especially in the third trimester, due to the risk of premature closure of the ductus arteriosus. Domperidone should also be used cautiously during breastfeeding, as it can pass into breast milk.

• Allergy to NSAIDs: If you have an allergy to NSAIDs or have a history of gastric ulcers, avoid using Naproxzen D 500 and consult your healthcare provider for alternatives.

• Kidney or Liver Disease: Use Naproxzen D 500 with caution if you have kidney or liver issues. Regular monitoring of kidney and liver function may be required during long-term use.

FAQ Section

Q1: How long does it take for Naproxzen D 500 to start working?
Naproxzen D 500 typically starts providing pain relief within 1-2 hours. The sustained-release formulation of domperidone ensures consistent effects over time.

Q2: Can I take Naproxzen D 500 with other medications?
Always consult your doctor before taking Naproxzen D 500 with other medications, especially other NSAIDs, blood thinners, or gastric medications to avoid potential interactions.

Q3: Is Naproxzen D 500 safe for long-term use?
For long-term use, your doctor may monitor your kidney and liver function regularly due to the potential risks of NSAIDs and domperidone. Use it as prescribed to minimize risks.

Q4: Can I stop taking Naproxzen D 500 once I feel better?
Do not stop taking Naproxzen D 500 without consulting your healthcare provider. It is important to complete the prescribed course to manage symptoms effectively.

Conclusion

Naproxzen D 500 is an effective combination of naproxen (500mg) and domperidone SR (30mg) that provides both pain relief and gastrointestinal benefits. It is ideal for individuals suffering from conditions like arthritis, musculoskeletal pain, dysmenorrhea, and nausea. As with any medication, it’s important to follow your doctor’s instructions for optimal results and safety.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

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