Chronic neuropathic pain is one of the most challenging medical conditions affecting millions of individuals across India. Patients experiencing diabetes-induced nerve damage, sciatica, neuralgia, fibromyalgia, or nerve compression often struggle with burning sensations, tingling, numbness, and persistent nerve pain that interferes with daily life. PREGABRIAL NTD3, a specially engineered formulation by Steris Healthcare Pvt. Ltd., brings a powerful combination of pregabalin (SR), nortriptyline, mecobalamin, and vitamin D3 to deliver comprehensive and long-lasting relief.

This advanced combination therapy targets the root causes of neuropathic pain through multiple mechanisms—nerve stabilization, neurotransmitter regulation, nerve repair, and strengthening of musculoskeletal health. PREGABRIAL NTD3 is ideal for patients who require a sustained, holistic, and effective solution for chronic nerve-related pain conditions.

Complete Composition of PREGABRIAL NTD3

Each tablet contains:

• Pregabalin (SR) 75 mg

• Nortriptyline 10 mg

• Mecobalamin (Vitamin B12) 1500 mcg

• Vitamin D3 (Cholecalciferol) 2000 IU

This formulation is optimized for maximum absorption, long duration of action, and enhanced patient compliance. The combination acts synergistically to control pain, repair damaged nerves, and prevent further nerve degeneration.

Understanding Each Ingredient in PREGABRIAL NTD3

1. Pregabalin (SR) 75 mg – Sustained Release for Long-Lasting Comfort

Pregabalin is one of the most widely used and clinically effective medicines for neuropathic pain. As an SR (sustained-release) formulation, it offers consistent pain control throughout the day without causing excessive drowsiness or fluctuations in pain intensity.

How Pregabalin Works

• Regulates abnormal electrical activity in damaged nerves

• Blocks calcium channels in nerve cells

• Reduces excessive neurotransmitter release

• Relieves burning, stabbing, or shooting pain

It is especially effective in conditions like:

• Diabetic neuropathy

• Sciatica

• Post-herpetic neuralgia

• Fibromyalgia

• Chronic nerve compression

2. Nortriptyline 10 mg – Mood Modulation + Pain Suppression

Nortriptyline is a tricyclic antidepressant with proven benefits in neuropathic pain management. It enhances the levels of serotonin and norepinephrine, the two crucial neurotransmitters responsible for pain modulation.

Benefits of Nortriptyline

• Improves pain tolerance

• Reduces nerve hypersensitivity

• Enhances sleep quality

• Helps manage anxiety linked with chronic pain

This ingredient complements pregabalin, offering a dual-action effect on nerve pain and mental well-being.

3. Mecobalamin 1500 mcg – Nerve Repair Vitamin B12

Mecobalamin (Methylcobalamin) is an active form of Vitamin B12 essential for nerve regeneration. It helps restore damaged nerve cells, improves nerve conduction, and reduces symptoms like:

• Tingling

• Numbness

• Burning sensation

• Muscle weakness

Why High Strength 1500 mcg?

Patients with chronic neuropathy often have low B12 levels. A therapeutic dose like 1500 mcg accelerates nerve healing and supports long-term recovery.

4. Vitamin D3 2000 IU – Musculoskeletal Support + Anti-inflammatory Action

Vitamin D3 deficiency is highly prevalent in India and contributes significantly to muscle pain, bone weakness, and inflammation. Supplementing with 2000 IU helps:

• Strengthen bones and muscles

• Reduce inflammation

• Improve nerve function

• Enhance absorption of calcium and essential minerals

This makes PREGABRIAL NTD3 a complete formula for pain relief and nerve health.

Uses of PREGABRIAL NTD3

PREGABRIAL NTD3 is primarily used for:

1. Diabetic Peripheral Neuropathy

Helps reduce chronic nerve pain caused by high blood sugar levels.

2. Sciatica and Radiculopathy

Relieves pain radiating from the lower back to the legs due to nerve compression.

3. Neuralgia

Effective for post-herpetic neuralgia (shingles nerve pain).

4. Cervical Spondylosis & Lumbar Spondylosis

Supports nerve function and reduces chronic nerve irritation.

5. Chemotherapy-Induced Neuropathy

Helps restore nerve function and reduces tingling or numbness caused by cancer treatment.

6. Alcoholic Neuropathy

Supports nerve healing and reduces symptoms caused by long-term alcohol use.

7. Fibromyalgia

Reduces widespread body pain, fatigue, and muscle stiffness.

8. Entrapment Neuropathies

Including carpal tunnel syndrome and ulnar neuropathy.

Benefits of PREGABRIAL NTD3

1. Multi-targeted Relief

Targets nerve pain, nerve repair, inflammation, and mood—delivering holistic care.

2. Long-acting Formula

Pregabalin SR ensures 12–24 hours of steady relief.

3. Better Nerve Regeneration

Due to high-strength mecobalamin.

4. Supports Bone and Muscle Strength

Vitamin D3 prevents weakness and pain caused by deficiency.

5. Improves Sleep and Reduces Anxiety

Nortriptyline enhances sleep quality and reduces stress associated with chronic pain.

6. Faster and More Effective Relief

Compared to single-ingredient neuropathic pain medicines.

7. Helps Prevent Future Nerve Damage

Due to the synergistic action of Pregabalin + B12 + Vitamin D3.

Why PREGABRIAL NTD3 is Superior to Competitor Products

• Uses a balanced and evidence-based combination

• Offers high-strength B12 (1500 mcg)—superior for nerve repair

• Contains Vitamin D3 2000 IU which many competitors lack

• Sustained-release Pregabalin ensures stable drug levels

• Manufactured by Steris Healthcare, ensuring premium quality

• More affordable than leading neuropathic pain combination brands

• Better patient compliance due to once or twice daily dosing

Mechanism of Action – How PREGABRIAL NTD3 Works in the Body

1. Pregabalin (SR) – Calms Overactive Nerves

Blocks calcium channels and stabilizes nerve signals.

2. Nortriptyline – Enhances Pain Control Pathways

Boosts serotonin and norepinephrine levels, improving brain-pain circuits.

3. Mecobalamin – Repairs Damaged Nerves

Promotes protein synthesis and supports myelin sheath formation.

4. Vitamin D3 – Strengthens Bones & Reduces Inflammation

Boosts nerve-muscle coordination and prevents deficiency-related pain.

Together, these ingredients offer a complete neuropathy treatment plan in a single tablet.

Dosage and Administration

Dosage depends on the patient’s condition, age, and clinical requirements.
A healthcare provider will determine the exact dose.

General Dosage Guidelines

• Usually taken once or twice daily

• Can be taken with or without food

• Swallow the tablet whole; do not crush

Important Reminders

• Do not stop suddenly

• Maintain consistent timing

• Avoid alcohol

• Follow your doctor’s guidance

Side Effects

Most patients tolerate PREGABRIAL NTD3 well. Some may experience:

• Drowsiness

• Dry mouth

• Dizziness

• Constipation

• Blurred vision

• Mild weight gain

These usually improve with continuous use.

Precautions and Warnings

• Not recommended in pregnancy unless advised by a doctor

• Use cautiously in kidney disorders

• Avoid alcohol consumption

• May cause drowsiness—do not drive immediately after intake

• Inform your doctor if taking antidepressants or anti-seizure medications

Storage Instructions

• Store below 30°C

• Keep away from moisture, sunlight, and children

Conclusion

PREGABRIAL NTD3 is an advanced, scientifically formulated therapy for neuropathic pain. With its unique combination of Pregabalin SR 75 mg, Nortriptyline 10 mg, Mecobalamin 1500 mcg, and Vitamin D3 2000 IU, it provides comprehensive relief by targeting pain, nerve repair, inflammation, and mental well-being.

Frequently Asked Questions 

1. How long does PREGABRIAL NTD3 take to work?

You may start noticing improvements within 1–2 weeks; significant relief usually appears in 3–4 weeks.

2. Can I take it daily?

Yes, it is designed for daily use as prescribed.

3. Is this safe for long-term use?

Yes, when monitored by a healthcare professional.

4. Can it be taken with diabetes medicine?

Yes, but only under medical supervision.

5. Does it help with back pain?

It helps if the back pain is due to nerve damage or nerve compression.