PAFAGOLD M 1000 Tablet- View Uses, Side Effects, Dosage, Mechanism of action...

PAFAGOLD M 1000

Dapagliflozin , Metformin Hydrochloride

PAFAGOLD M 1000 is a combination medication used to manage type 2 diabetes mellitus. This powerful duo, consisting of Dapagliflozin and Metformin Hydrochloride, works synergistically to control blood sugar levels in adults. In this article, we will delve into the uses, dosage, side effects, composition, and more, ensuring a thorough understanding of PAFAGOLD M 1000.

Composition

PAFAGOLD M 1000 contains two active ingredients:

• Dapagliflozin: 10 mg
• Metformin Hydrochloride: 1000 mg

Mechanism of Action

Dapagliflozin belongs to a class of medications known as SGLT2 inhibitors. It works by blocking the sodium-glucose co-transporter 2 protein in the kidneys, preventing glucose reabsorption and promoting its excretion through urine. This helps lower blood glucose levels.

Metformin Hydrochloride is a biguanide that decreases hepatic glucose production, reduces intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. Together, these mechanisms help maintain optimal blood sugar levels.

Uses

PAFAGOLD M 1000 is prescribed for:

• Management of type 2 diabetes mellitus
• Improving glycemic control in conjunction with diet and exercise
• Reducing the risk of cardiovascular events in patients with type 2 diabetes

Dosage and Administration

The dosage of PAFAGOLD M 1000 should be individualized based on the patient's current treatment regimen, effectiveness, and tolerability. Typically, the recommended starting dose is:

• Dapagliflozin: 10 mg once daily
• Metformin Hydrochloride: 500 mg or 1000 mg twice daily, gradually increased based on tolerance and efficacy

How to Take PAFAGOLD M 1000

• Take the medication orally with meals to minimize gastrointestinal side effects.
• Swallow the tablet whole; do not crush, chew, or break it.
• Maintain a consistent schedule to ensure stable blood sugar levels.

Side Effects

Like any medication, PAFAGOLD M 1000 may cause side effects. Common side effects include:

• Gastrointestinal disturbances (nausea, vomiting, diarrhea)
• Genital infections (yeast infections in women, balanitis in men)
• Urinary tract infections
• Increased urination
• Hypoglycemia (when combined with other diabetes medications)

Serious but rare side effects may include:

• Lactic acidosis (a serious metabolic complication associated with Metformin)
• Dehydration and low blood pressure due to diuresis
• Ketoacidosis (a serious condition that can occur even with normal blood sugar levels)

Precautions and Warnings

• Renal Function: Monitor renal function before initiating treatment and periodically thereafter, as both components can affect kidney function.
• Hypersensitivity: Avoid use in patients with a known hypersensitivity to Dapagliflozin, Metformin, or any component of the formulation.
• Lactic Acidosis: Due to the risk associated with Metformin, caution is advised in patients with conditions predisposing them to lactic acidosis.
• Fluid Loss: Monitor for signs of fluid loss, especially in elderly patients or those on diuretics.

Interactions

PAFAGOLD M 1000 can interact with several medications, potentially altering their effects. Some notable interactions include:

• Diuretics: May enhance the diuretic effect, increasing the risk of dehydration and hypotension.
• Insulin or Insulin Secretagogues: Increases the risk of hypoglycemia.
• Radiologic Studies with Contrast: Temporary discontinuation of Metformin is recommended to reduce the risk of lactic acidosis.
• Alcohol: Can potentiate the effect of Metformin on lactate metabolism, increasing the risk of lactic acidosis.

Monitoring

Regular monitoring is crucial to ensure the safe and effective use of PAFAGOLD M 1000:

• Blood Glucose Levels: Regular monitoring helps assess the efficacy of the medication.
• Renal Function: Periodic assessment of kidney function is necessary.
• HbA1c Levels: To evaluate long-term glycemic control.

Lifestyle and Dietary Recommendations

• Diet: Follow a balanced diet rich in fiber, low in refined sugars and saturated fats.
• Exercise: Regular physical activity helps improve insulin sensitivity and overall health.
• Hydration: Maintain adequate fluid intake to prevent dehydration.

Conclusion

PAFAGOLD M 1000, combining Dapagliflozin and Metformin Hydrochloride, offers an effective solution for managing type 2 diabetes mellitus. By understanding its uses, dosage, side effects, and precautions, patients can optimize their treatment and improve their quality of life. Always consult with a healthcare provider for personalized advice and monitoring while using this medication. Steris Healthcare Pvt Ltd, established in February 2018 by seasoned professionals in the pharmaceutical sector, operates under the name Sterispharma. Headquartered in Navi Mumbai, the company is certified by WHO, GMP, and ISO. Sterispharma is dedicated to providing high-quality medications at affordable prices across India, adhering to stringent WHO guidelines. They offer an online pharmacy platform for easy medicine purchases and home delivery. The company's mission is to deliver a diverse range of healthcare products catering to the varied needs of the medical community. From advanced treatments and rare condition medications to essential health supplies, Sterispharma aims to meet the extensive demands of the healthcare industry. Their product range covers numerous health fields, including Cardiology, Asthma, Respiratory issues, Nasal conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental care, and Dermatology.

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