Pantoprazole (40mg), Levosulpiride (75mg SR) & PANTOSTRUM LS : Tablet Steris Healthcare PVT LTD

PANTOSTRUM LS 

Pantoprazole (40mg), Levosulpiride (75mg SR)

PANTOSTRUM LS is a widely recognized pharmaceutical formulation that combines Pantoprazole (40mg) and Levosulpiride (75mg SR). This potent combination is primarily used to manage gastrointestinal disorders such as gastroesophageal reflux disease (GERD), peptic ulcers, and functional dyspepsia. In this comprehensive guide, we will delve into the pharmacological properties, therapeutic benefits, usage guidelines, and potential side effects of PANTOSTRUM LS.

Pharmacological Properties

Pantoprazole

• Class: Proton pump inhibitor (PPI)
• Mechanism of Action: Pantoprazole works by irreversibly inhibiting the H+/K+ ATPase enzyme system of the gastric parietal cells, leading to a significant reduction in gastric acid secretion.
• Therapeutic Use: It is highly effective in treating acid-related disorders, providing relief from symptoms such as heartburn, acid regurgitation, and gastric discomfort.

Levosulpiride

• Class: Benzamide antipsychotic and prokinetic agent
• Mechanism of Action: Levosulpiride acts as a selective dopamine D2 receptor antagonist, enhancing gastric motility and promoting gastrointestinal emptying.
• Therapeutic Use: It is used to manage symptoms of functional dyspepsia, chronic gastritis, and irritable bowel syndrome (IBS), contributing to improved gastrointestinal function and patient comfort.

Therapeutic Benefits

1. Effective Acid Suppression

• Pantoprazole, as a PPI, provides robust acid suppression, making it highly effective in managing conditions like GERD and peptic ulcers.
• Reduced acid secretion aids in the healing of erosive esophagitis and prevents the recurrence of gastric ulcers.

2. Enhanced Gastric Motility

• Levosulpiride's prokinetic properties help improve gastric emptying and intestinal transit, alleviating symptoms of bloating, nausea, and abdominal discomfort.
• This dual action of acid suppression and enhanced motility addresses both the acid-related and motility-related components of gastrointestinal disorders.

3. Symptom Relief and Quality of Life

• The combination of Pantoprazole and Levosulpiride provides comprehensive symptom relief, significantly improving the quality of life for patients with chronic gastrointestinal conditions.
• Patients experience reduced frequency and severity of heartburn, regurgitation, and epigastric pain.

Usage Guidelines

Dosage and Administration

• Recommended Dose: One PANTOSTRUM LS tablet per day, preferably before meals.
• Duration of Therapy: The duration of treatment may vary based on the severity of the condition and the patient’s response to therapy.

Special Populations

• Elderly Patients: Dosage adjustment may be required based on renal and hepatic function.
• Pregnancy and Lactation: PANTOSTRUM LS should be used during pregnancy and lactation only if the potential benefits justify the potential risks. Consultation with a healthcare provider is crucial.

Drug Interactions

• Concomitant Medications: PANTOSTRUM LS may interact with other medications such as anticoagulants, antiplatelet agents, and certain antibiotics. It is essential to inform the healthcare provider about all current medications.
• Food Interactions: For optimal absorption, it is recommended to take PANTOSTRUM LS before meals. Avoiding high-fat meals may enhance the drug’s effectiveness.

Potential Side Effects

Common Side Effects

• Gastrointestinal: Nausea, vomiting, diarrhea, constipation, abdominal pain
• Central Nervous System: Headache, dizziness, fatigue
• Others: Rash, pruritus, injection site reactions

Serious Side Effects

• Cardiovascular: Palpitations, chest pain
• Neurological: Seizures, severe dizziness, confusion
• Allergic Reactions: Anaphylaxis, angioedema

Precautions and Warnings

1. Risk of Osteoporosis-Related Fractures

• Long-term use of PPIs like Pantoprazole may increase the risk of osteoporosis-related fractures. It is advisable to use the lowest effective dose for the shortest duration necessary.

2. Clostridium difficile-Associated Diarrhea

• PPI therapy has been associated with an increased risk of Clostridium difficile-associated diarrhea. Monitoring and appropriate management are essential in patients presenting with diarrhea.

3. Electrolyte Imbalance

• Long-term use of PANTOSTRUM LS may lead to electrolyte imbalances such as hypomagnesemia. Regular monitoring of magnesium levels is recommended, especially in patients on prolonged therapy.

4. Neuropsychiatric Symptoms

• Levosulpiride may cause neuropsychiatric symptoms such as agitation, anxiety, and depression.

Conclusion

PANTOSTRUM LS, combining Pantoprazole (40mg) and Levosulpiride (75mg SR), offers a comprehensive treatment approach for various gastrointestinal disorders. Its dual mechanism of action—effective acid suppression and enhanced gastric motility—addresses the multifaceted nature of conditions like GERD, peptic ulcers, and functional dyspepsia. Adhering to prescribed usage guidelines and being aware of potential side effects and interactions can help maximize the therapeutic benefits of PANTOSTRUM LS. Always consult a healthcare provider for personalized medical advice and treatment plans.  Steris Healthcare Pvt Ltd, founded by a group of expert professionals in the pharmaceutical industry in February 2018, operates as Sterispharma. This company, which is based in Navi Mumbai, holds certifications from WHO, GMP, and ISO. Its commitment is to provide high-quality drugs at affordable prices to its customers throughout India, following the rigorous guidelines set by the WHO. Steris offers the convenience of an online pharmacy where customers can easily buy medicines and enjoy the benefit of home delivery. At Steris, the mission is to supply a wide array of healthcare products designed to meet the varied needs of the medical community. Whether it is advanced treatments, medications for rare conditions, or basic health necessities, Sterispharma strives to serve the healthcare industry’s broad demands. The extensive product lineup from Steris includes treatments for various health areas such as Cardiology, Asthma, Respiratory issues, Nasal conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental care, and Dermatology.

For further information: 

EMAIL:  info@sterispharma.com  / contact@sterispharma.com   

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