PERINDPRIM PLUS : Uses, Interactions, Mechanism of Action - STERIS PHARMA

PERINDPRIM PLUS 

Perindopril & Indapamide

Perindprim Plus is a combination medication used to manage and treat hypertension (high blood pressure). This pharmaceutical blend combines Perindopril, an ACE (angiotensin-converting enzyme) inhibitor, and Indapamide, a thiazide-like diuretic. The synergistic effect of these two components helps in efficiently controlling blood pressure, reducing the risk of cardiovascular events such as strokes and heart attacks. Understanding the uses, dosage, side effects, and precautions of Perindprim Plus is crucial for optimal therapeutic outcomes.

Uses

Perindprim Plus is primarily indicated for the treatment of hypertension. The combination of Perindopril and Indapamide works through different mechanisms to lower blood pressure:

1. Perindopril: This ACE inhibitor functions by blocking the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This leads to vasodilation, reducing the pressure in the blood vessels.
2. Indapamide: As a thiazide-like diuretic, Indapamide increases the excretion of sodium and water through the kidneys, decreasing blood volume and consequently lowering blood pressure.

The combination of these two medications ensures a comprehensive approach to managing high blood pressure, providing benefits that exceed those of monotherapy.

Dosage

The dosage of Perindprim Plus is determined by the healthcare provider based on the individual’s medical condition and response to treatment. Generally, the starting dose is one tablet taken once daily, preferably in the morning to align with the body’s natural diurnal rhythm. It is essential to take the medication at the same time each day to maintain consistent blood levels.

• Initial Dose: One tablet daily, usually containing 4 mg of Perindopril and 1.25 mg of Indapamide.

Patients should not alter the dosage without consulting their healthcare provider. Abrupt changes can lead to adverse effects or reduced efficacy.

Side Effects

Like all medications, Perindprim Plus may cause side effects, although not everyone experiences them. Common side effects include:

• Dizziness or lightheadedness: Often due to the blood pressure-lowering effects.
• Cough: A known side effect of ACE inhibitors like Perindopril.
• Electrolyte imbalances: Such as low potassium or sodium levels, due to the diuretic effect of Indapamide.
• Fatigue: Feeling unusually tired or weak.
• Headache: Mild to moderate headaches.
• Severe allergic reactions (rash, itching, swelling of the face/tongue/throat, severe dizziness, trouble breathing).
• Severe hypotension (very low blood pressure).
• Kidney problems (change in the amount of urine, swelling of the ankles/feet).
• Signs of an electrolyte imbalance (muscle cramps, weakness, irregular heartbeat).

Precautions

Before starting Perindprim Plus, it is crucial to inform your healthcare provider about any pre-existing conditions and other medications you are taking. Specific precautions include:

• Allergies: Inform your doctor if you are allergic to Perindopril, Indapamide, or any other ACE inhibitors or sulfonamides.
• Medical History: Discuss your medical history, especially if you have kidney disease, liver disease, lupus, gout, or electrolyte imbalances.
• Pregnancy and Breastfeeding: Perindopril can harm an unborn baby if taken during pregnancy. It is crucial to use effective contraception and inform your doctor immediately if you become pregnant. It is unknown if Indapamide passes into breast milk; therefore, breastfeeding is not recommended while using this medication.
• Surgery: Inform your surgeon or dentist that you are using this medication before any surgery or dental procedure.
• Alcohol: Limit alcoholic beverages, as alcohol can enhance certain side effects of Perindprim Plus, such as dizziness and lightheadedness.

Interactions

Perindprim Plus can interact with other medications, potentially altering their effects or increasing the risk of serious side effects. Inform your healthcare provider about all the drugs you are taking, including:

• Other antihypertensives: Combined effects may excessively lower blood pressure.
• Potassium supplements or salt substitutes: Increased risk of high potassium levels.
• NSAIDs (e.g., ibuprofen, naproxen): May reduce the effectiveness of Perindopril and increase the risk of kidney problems.
• Lithium: Increased risk of lithium toxicity.
• Diuretics: Can potentiate the effect of Indapamide.

Monitoring and Follow-up

Regular monitoring of blood pressure, kidney function, and electrolyte levels is essential for patients taking Perindprim Plus. Scheduled follow-ups with the healthcare provider help in adjusting the dosage and ensuring the medication's efficacy and safety.

Conclusion

Perindprim Plus, combining Perindopril and Indapamide, offers a robust solution for managing hypertension. By understanding its uses, dosage, side effects, precautions, and potential interactions, patients can maximize the benefits of this medication while minimizing risks. Always consult with a healthcare provider for personalized advice and follow their recommendations to ensure optimal treatment outcomes. Steris Healthcare Pvt Ltd, founded by a group of expert professionals in the pharmaceutical industry in February 2018, operates as Sterispharma. This company, which is based in Navi Mumbai, holds certifications from WHO, GMP, and ISO. Its commitment is to provide high-quality drugs at affordable prices to its customers throughout India, following the rigorous guidelines set by the WHO. Steris offers the convenience of an online pharmacy where customers can easily buy medicines and enjoy the benefit of home delivery. At Steris, the mission is to supply a wide array of healthcare products designed to meet the varied needs of the medical community. Whether it is advanced treatments, medications for rare conditions, or basic health necessities, Sterispharma strives to serve the healthcare industry’s broad demands. The extensive product lineup from Steris includes treatments for various health areas such as Cardiology, Asthma, Respiratory issues, Nasal conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental care, and Dermatology.

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