PR (12.5mg) Metaprolol

Introduction

Metoprolol Succinate is a beta-1 selective beta-blocker that helps control high blood pressure, chronic heart failure, angina, and arrhythmias. The extended-release formulation (XR or PR) ensures a sustained release of the drug over 24 hours, providing consistent therapeutic action with once-daily dosing.

Metoprolol 12.5 mg Uses

METAPROLATE XR 12.5 is prescribed for:

• Hypertension (high blood pressure)

• Chronic stable angina (chest pain)

• Heart failure (as part of combination therapy)

• Post-myocardial infarction (heart attack) management

• Irregular heartbeats (arrhythmias)

• Migraine prophylaxis (off-label)

 It reduces the heart's workload and oxygen demand, helping prevent angina attacks and cardiac stress.

Metoprolol Succinate Mechanism of Action

Metoprolol works by:

• Blocking beta-1 adrenergic receptors in the heart

• Reducing heart rate, cardiac output, and blood pressure

• Slowing AV node conduction, which helps in managing arrhythmias

• Lowering the heart’s oxygen demand, beneficial in ischemic heart conditions

It is cardioselective, meaning it primarily targets the heart and is less likely to cause bronchoconstriction.

Dosage and Administration

• Typical adult dose:

  • Start with 12.5–25 mg once daily, increased as needed under medical supervision.

• For heart failure:

  • Begin with a low dose (12.5 mg), gradually titrated based on tolerance and heart rate.

Take METAPROLATE XR 12.5 with or after food to enhance absorption and reduce side effects.

Metoprolol Side Effects

Common Side Effects:

• Tiredness or fatigue

• Dizziness or lightheadedness

• Slow heart rate (bradycardia)

• Cold hands or feet

• Gastrointestinal upset

Serious Side Effects (Rare):

• Severe bradycardia or hypotension

• Shortness of breath (especially in asthma/COPD patients)

• Depression or mood changes

• Worsening of heart failure symptoms

Precautions and Warnings

• Do not stop suddenly – may lead to worsening angina or heart attack.

• Use with caution in:

  • Asthma or COPD (may worsen bronchospasm)

  • Diabetes (can mask hypoglycemia symptoms)

  • Bradycardia or AV block

• Pregnancy & Breastfeeding: Use only if prescribed by your doctor.

Drug Interactions

Avoid combining with:

• Calcium channel blockers like verapamil or diltiazem (increased bradycardia risk)

• Clonidine (may lead to rebound hypertension)

• Antiarrhythmics

• Insulin or oral hypoglycemics (masked hypoglycemia symptoms)

Storage Instructions

• Store below 25°C in a dry place

• Protect from light and moisture

• Keep away from children

FAQs About Metoprolol 12.5 mg (METAPROLATE XR 12.5)

1. What is METAPROLATE XR 12.5 used for?

It is used to treat high blood pressure, angina, arrhythmias, and heart failure, and is often given after a heart attack to prevent recurrence.

2. Can I stop taking Metoprolol suddenly?

No. Stopping suddenly may cause chest pain or even a heart attack. Tapering must be done under medical supervision.

3. Can Metoprolol 12.5 mg cause fatigue?

Yes, fatigue and dizziness are common, especially when starting the medication. These often subside with continued use.

4. Is it safe in asthma patients?

Metoprolol is cardioselective, but caution is advised in asthma/COPD as it may still cause bronchospasm.

5. When should I take METAPROLATE XR 12.5?

It is best taken once daily with food, preferably at the same time each day for consistent effect.

Conclusion

METAPROLATE XR 12.5 is a low-dose, prolonged-release formulation of Metoprolol Succinate that offers safe, once-daily blood pressure and heart rhythm control. Its cardioselectivity, tolerability, and extended-release profile make it ideal for long-term management of cardiovascular conditions.

About The Company

Steris Healthcare Pvt Ltd, widely recognized as Sterispharma, was established in February 2018 by a team of seasoned experts from the pharmaceutical sector. Based in Navi Mumbai, the company is proudly certified by WHO, GMP, and ISO, underscoring its unwavering commitment to quality and patient safety. Sterispharma is driven by a mission to make affordable, premium-quality medicines accessible throughout India, adhering strictly to WHO-recommended standards. Through its user-friendly online pharmacy platforms, customers can effortlessly order medications with home delivery services.

Sterispharma boasts an extensive portfolio of healthcare solutions, ranging from treatments for rare diseases to essential everyday healthcare needs. Their comprehensive product lineup addresses multiple therapeutic areas including Cardiology, Asthma, Respiratory Disorders, Nasal Care, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infective/Antibiotic Therapy, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental Care, and Dermatology. Medications are easily available for online purchase through their official websites — Sterisonline, Sterisindia, and Sterispharma — offering a seamless and reliable healthcare experience.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

BUY NOW