Pregabalin and Methylcobalamin Capsules Uses, Dosage & Side Effects

Introduction – pregabalin and methylcobalamin capsules uses

Pregabalin and methylcobalamin capsules are a combination medication primarily used for the treatment of neuropathic pain, which is nerve pain caused by damaged nerves. One of the most widely prescribed and effective combinations to treat these conditions is PREGABRIAL M, a trusted formulation of pregabalin and methylcobalamin capsules.This article explores in detail the pregabalin and methylcobalamin capsules uses, their mechanism of action, dosage, clinical benefits, possible side effects, and why PREGABRIAL M from Steris Healthcare Pvt. Ltd. is a preferred choice by doctors across India.

Composition of PREGABRIAL M

Each capsule of PREGABRIAL M contains:

• Pregabalin IP – 75 mg / 150 mg

• Methylcobalamin (Vitamin B12) – 750 mcg / 1500 mcg

Dosage forms available: Hard gelatin capsules
Packaging: 10x10 blister/strip pack (customizable as per requirement)

What are pregabalin and methylcobalamin?

Pregabalin

Pregabalin is a gamma-aminobutyric acid (GABA) analogue used primarily for neuropathic pain, partial seizures, and generalized anxiety disorder. It reduces abnormal nerve activity in the brain and peripheral nerves, thereby alleviating pain and discomfort.

Methylcobalamin

Methylcobalamin is the neurologically active form of vitamin B12. It supports nerve regeneration, promotes myelin sheath repair, and improves nerve conduction velocity. It is crucial in treating nerve damage due to diabetes, alcohol, or vitamin B12 deficiency.Together, they form a synergistic combination that treats and manages various forms of nerve damage and associated symptoms.

Pregabalin and Methylcobalamin Capsules Uses

The primary pregabalin and methylcobalamin capsules uses include:

• Diabetic Neuropathy – Nerve pain caused by long-term diabetes

• Peripheral Neuropathy – Numbness, tingling, and pain in hands/feet

• Sciatica and Lumbar Radiculopathy – Nerve compression causing radiating pain

• Post-Herpetic Neuralgia – Nerve pain following shingles (herpes zoster)

• Trigeminal Neuralgia – Severe facial nerve pain

• Alcoholic Neuropathy – Nerve damage due to chronic alcohol use

• Vitamin B12 Deficiency-induced Neuropathy

• Fibromyalgia – Widespread muscle and nerve pain

• Adjunct therapy in epilepsy and anxiety disorders

This capsule is not only curative but also preventive in progressive nerve degeneration cases.

Mechanism of Action

Pregabalin binds to the α2δ subunit of voltage-gated calcium channels in the central nervous system. This reduces the release of excitatory neurotransmitters, thereby decreasing nerve excitability and pain perception.

Methylcobalamin is involved in methylation reactions necessary for myelin synthesis and DNA replication. It directly supports nerve repair and regeneration.

This combination acts synergistically – pregabalin reduces nerve pain while methylcobalamin repairs nerve damage, offering holistic relief.

Dosage and Administration – pregabalin and methylcobalamin capsules dosage

The typical pregabalin and methylcobalamin capsules dosage is:

• Initial dose: Once or twice daily depending on severity

• Maintenance:

  • Pregabalin 75–150 mg per day

  • Methylcobalamin 750–1500 mcg per day

Dosage should be individualized based on age, medical condition, and response.

Capsules should be swallowed whole with water, preferably after food.

DO NOT abruptly stop the medication without medical advice, as it may cause withdrawal symptoms.

Efficacy and Clinical Evidence

• Clinical studies show that the pregabalin and methylcobalamin combination is more effective than either agent alone.

• In diabetic neuropathy trials, patients showed up to 60–70% pain relief after 12 weeks of consistent use.

• Methylcobalamin therapy improves nerve conduction velocity and reverses nerve damage symptoms within 4–8 weeks.

This combination is widely accepted and recommended by neurologists, diabetologists, and pain specialists.

Side Effects – pregabalin and methylcobalamin capsules side effects

Like all medications, pregabalin and methylcobalamin capsules may have side effects:

Common side effects:

• Dizziness

• Sleepiness or drowsiness

• Weight gain

• Blurred vision

• Mild headache or fatigue

• Gastrointestinal discomfort

Rare but serious side effects:

• Mood changes or suicidal thoughts

• Allergic reactions

• Swelling of hands or feet

If any of these symptoms persist or worsen, consult your physician immediately.

Contraindications and Precautions

• Known allergy to pregabalin or vitamin B12

• Severe kidney or liver impairment

• Pregnant or breastfeeding women (use with caution)

• History of depression or substance abuse

Avoid alcohol and driving while taking pregabalin, as it may cause drowsiness.

Drug Interactions

• CNS depressants (e.g., benzodiazepines, opioids) may enhance drowsiness

• Alcohol may increase the risk of side effects

• Inform your doctor about all ongoing medications or supplements

Frequently Asked Questions (FAQs)

Q1. What are the uses of pregabalin and methylcobalamin capsules?

They are used to treat nerve pain, numbness, and nerve damage caused by conditions like diabetes, sciatica, and vitamin B12 deficiency.

Q2. How long should I take PREGABRIAL M?

The course duration depends on your condition. For chronic neuropathies, long-term use under medical supervision is common.

Q3. Can I take this capsule on an empty stomach?

It is best taken after meals to minimize gastric discomfort.

Q4. Are there any side effects?

Yes, some patients may experience dizziness, drowsiness, or stomach upset. Most effects are mild and temporary.

Q5. Is PREGABRIAL M habit-forming?

Pregabalin can cause dependence in rare cases if misused. Follow your doctor’s instructions strictly.

Conclusion – pregabalin and methylcobalamin capsules uses

In conclusion, PREGABRIAL M offers a scientifically backed and clinically proven solution to nerve-related disorders. The synergistic action of pregabalin and methylcobalamin capsules makes it ideal for managing chronic neuropathic pain, nerve degeneration, and vitamin B12 deficiency.Whether you're a diabetic patient, dealing with sciatica, or facing numbness and tingling, this capsule provides both symptomatic relief and nerve healing. The wide range of pregabalin and methylcobalamin capsules uses makes it an essential tool in neurological care.Choose PREGABRIAL M from Steris Healthcare – a name trusted for quality, reliability, and patient-first solutions.