Pregabalin and Nortriptyline Tablets Uses in Neuropathic Pain & Fibromyalgia

Introduction

Pregabalin and nortriptyline tablets uses include the treatment of various types of neuropathic pain, which is nerve pain caused by conditions such as diabetes, spinal disorders, shingles, or nerve compression syndromes. Marketed as PREGABRIAL NT, this combination of Pregabalin 75 mg and Nortriptyline 10 mg provides dual-action relief by calming nerve activity and enhancing mood, making it a widely trusted choice in long-term pain management.

Composition

• Pregabalin – 75 mg

• Nortriptyline – 10 mg

• Form – Oral tablet

• Brand Name – PREGABRIAL NT

Pregabalin and Nortriptyline Tablets Uses

The combination is commonly used in the treatment of:

• Diabetic neuropathy

• Postherpetic neuralgia (pain after shingles)

• Sciatica and spinal nerve pain

• Fibromyalgia

• Chronic lower back and neck pain with nerve involvement

• Nerve-related pain after injury or surgery

• Sometimes used off-label in fibromyalgia with anxiety symptoms

This combination provides both pain relief and mood stabilization, especially in chronic pain patients with poor quality of life due to persistent nerve irritation.

How Does It Work?

Pregabalin 75 mg:

• It is a GABA analogue, though it doesn’t act directly on GABA receptors.

• It binds to the alpha-2-delta subunit of calcium channels in the central nervous system, reducing the release of pain-transmitting neurotransmitters like glutamate, substance P, and norepinephrine.

• Helps in reducing nerve signal overactivity, thereby controlling neuropathic pain and anxiety.

Nortriptyline 10 mg:

• A tricyclic antidepressant (TCA) that inhibits the reuptake of norepinephrine and serotonin, enhancing their pain-relieving and mood-stabilizing effects.

• It also helps in modulating nerve activity, providing relief in nerve-based pain conditions.

Together, they offer synergistic action in reducing nerve pain, improving sleep, and enhancing mood.

Dosage and Administration

• Typical dose: One tablet once or twice daily

• Take after food to minimize stomach upset

• Do not stop abruptly—dose should be tapered under medical supervision

Pregabalin Side Effects and Nortriptyline Effects

Common Side Effects

• Dizziness or drowsiness

• Dry mouth

• Blurred vision

• Constipation

• Weight gain

• Fatigue

Serious (but rare) Side Effects

• Mood changes or suicidal thoughts

• Difficulty urinating

• Irregular heartbeat

• Allergic reactions (rash, swelling)

Regular monitoring and dose adjustments help minimize side effects.

Precautions

• Use with caution in elderly patients and those with heart, liver, or kidney issues

• Avoid alcohol and sedatives (may increase drowsiness)

• Not recommended during pregnancy or breastfeeding unless advised

• Do not drive or operate heavy machinery until you know how the medicine affects you

Why This Combination Is Preferred

• Dual Mechanism: Combines pain relief (Pregabalin) + mood stabilization & sleep regulation (Nortriptyline)

• Fewer tablets: Improves compliance as one pill does the work of two

• Long-lasting relief in chronic conditions

• Better quality of life for patients with diabetic neuropathy or fibromyalgia

Important Advice for Patients

• Do not drive or operate heavy machinery after taking this medication.

• Avoid alcohol completely – increases drowsiness and risk of falls.

• Take at the same time daily to maintain steady levels.

• Don’t stop abruptly – taper down with doctor’s advice.

• Keep track of mood, weight, and appetite regularly.

Why Steris is Better Than Other Pharmacies

Steris is known for its GMP-certified manufacturing, regulatory excellence, and high-quality standards. With a focus on safe, effective, and reliable products, Steris has become a trusted name in pharmaceutical care, offering better consistency than many local alternatives.

FAQs – Pregabalin and Nortriptyline Tablets

Q1. What are pregabalin and nortriptyline tablets used for?

They are mainly used for neuropathic pain due to diabetes, shingles, nerve injury, or spinal compression.

Q2. Can PREGABRIAL NT be taken long term?

Yes, it is safe for long-term use under medical supervision with regular monitoring.

Q3. Do these tablets help with anxiety?

Nortriptyline may help reduce anxiety symptoms that often accompany chronic pain.

Q4. Is weight gain common with this medicine?

Yes, weight gain is a possible side effect due to increased appetite or fluid retention.

Conclusion

Pregabalin and nortriptyline tablets offer an effective and well-tolerated solution for managing chronic neuropathic pain. With the combined benefits of nerve pain relief and mood stabilization, PREGABRIAL NT plays a vital role in improving patient comfort and quality of life. When sourced from reliable pharmaceutical companies like Steris, patients and healthcare providers can trust in the product's consistency, safety, and therapeutic value. Always consult a healthcare professional for appropriate dosage and monitoring.