PRUCOLPRIDE 2  Prucalopride (2mg): Uses, Side effect, Dosage, Pictures and more.....

PRUCOLPRIDE 2 

Prucalopride (2mg)

PRUCOLPRIDE 2 contains Prucalopride (2mg), which is a medication primarily used to treat chronic constipation in patients for whom standard laxatives have proven ineffective. This guide provides an in-depth look into PRUCOLPRIDE 2, covering its uses, dosage, mechanism of action, side effects, precautions, and more.

What is PRUCOLPRIDE 2?

PRUCOLPRIDE 2 contains 2mg of Prucalopride, a selective serotonin 5-HT4 receptor agonist. This medication is designed to stimulate bowel movements by enhancing colonic motility, making it an effective treatment option for chronic constipation.

Uses of PRUCOLPRIDE 2

Chronic Constipation

PRUCOLPRIDE 2 is primarily prescribed for adults suffering from chronic idiopathic constipation (CIC). It is particularly beneficial for patients who have not responded adequately to other forms of laxative therapy. By stimulating bowel movements, PRUCOLPRIDE 2 helps relieve the discomfort and health issues associated with prolonged constipation.

Off-label Uses

While the primary indication is chronic constipation, Prucalopride may sometimes be used off-label for other gastrointestinal motility disorders, although such uses should always be under strict medical supervision.

Mechanism of Action

Prucalopride, the active ingredient in PRUCOLPRIDE 2, works by selectively stimulating serotonin (5-HT4) receptors in the gut. This action enhances peristalsis, the wave-like contractions that move contents through the intestines. By promoting these contractions, Prucalopride helps facilitate more frequent and easier bowel movements.

Dosage and Administration

Standard Dosage

The recommended dosage of PRUCOLPRIDE 2 for adults is one 2mg tablet taken once daily. It can be taken with or without food, depending on patient preference and tolerability.

Special Populations

• Elderly Patients: For patients aged 65 and older, the initial dose may be 1mg once daily, which can be increased to 2mg if necessary.
• Renal Impairment: In patients with severe renal impairment (creatinine clearance < 30 mL/min), a lower starting dose of 1mg is recommended.
• Hepatic Impairment: No dosage adjustment is required for patients with mild to moderate hepatic impairment. However, caution is advised for those with severe hepatic impairment.

Missed Dose

If a dose is missed, it should be taken as soon as the patient remembers. However, if it is almost time for the next dose, the missed dose should be skipped, and the regular dosing schedule resumed. Double dosing to make up for a missed dose is not recommended.

Side Effects

Common Side Effects

• Headache: Some patients may experience mild to moderate headaches.
• Nausea: Nausea is a common side effect, especially during the initial days of treatment.
• Diarrhea: Increased bowel movements can sometimes lead to diarrhea.
• Abdominal Pain: Mild to moderate abdominal discomfort or pain may occur.

Serious Side Effects

• Severe Allergic Reactions: Although rare, severe allergic reactions like rash, itching, and difficulty breathing can occur. Immediate medical attention is required.
• Cardiovascular Events: Prucalopride has been associated with potential cardiovascular effects, including palpitations and arrhythmias. Patients with a history of cardiovascular disease should use this medication with caution.

Precautions and Warnings

Contraindications

• Hypersensitivity: Patients with known hypersensitivity to Prucalopride or any of the excipients in PRUCOLPRIDE 2 should not use this medication.
• Intestinal Perforation/Obstruction: Patients with known or suspected intestinal perforation or obstruction should avoid using PRUCOLPRIDE 2.

Precautions

• Cardiovascular Health: Patients with a history of cardiovascular diseases should be monitored closely while on PRUCOLPRIDE 2 due to the potential for cardiovascular side effects.
• Severe Renal Impairment: Patients with severe renal impairment should start on a lower dose and be monitored for adverse effects.

Pregnancy and Breastfeeding

• Pregnancy: The safety of PRUCOLPRIDE 2 during pregnancy has not been fully established. It should only be used if the potential benefits justify the potential risks to the fetus.
• Breastfeeding: It is not known if Prucalopride is excreted in human milk. Caution should be exercised, and a healthcare provider should be consulted before use during breastfeeding.

Interactions

Drug Interactions

• Other Laxatives: Concurrent use of other laxatives may increase the risk of diarrhea.
• Ketoconazole: Co-administration with ketoconazole can increase Prucalopride levels due to inhibition of CYP3A4, necessitating close monitoring.
• Digoxin: There may be an interaction with digoxin, and patients should be monitored for digoxin toxicity.

Food Interactions

PRUCOLPRIDE 2 can be taken with or without food. There are no significant food interactions, allowing flexibility in dosing schedules.

Patient Experience

Efficacy

Many patients report significant improvement in bowel movement frequency and ease within the first week of starting PRUCOLPRIDE 2. This improvement leads to better overall comfort and quality of life.

Tolerability

While initial side effects like headache and nausea are common, they often subside with continued use. Most patients find PRUCOLPRIDE 2 well-tolerated and effective in managing their chronic constipation.

Conclusion

PRUCOLPRIDE 2 (Prucalopride 2mg) is a highly effective treatment for chronic constipation, especially in patients who have not responded well to traditional laxatives. By enhancing colonic motility through selective serotonin receptor stimulation, it provides significant relief from constipation-related discomfort. However, like all medications, it is essential to use PRUCOLPRIDE 2 under the guidance of a healthcare professional, considering its potential side effects and interactions. If you suffer from chronic constipation, consult your doctor to see if PRUCOLPRIDE 2 could be the right solution for you. Steris Healthcare Pvt Ltd, operating as Sterispharma since its founding by expert professionals in the pharmaceutical industry in February 2018, is based in Navi Mumbai. The company is certified by WHO, GMP, and ISO, emphasizing its commitment to quality and safety. Sterispharma focuses on providing high-quality drugs at affordable prices throughout India, adhering strictly to WHO guidelines. Offering the convenience of an online pharmacy, customers can easily purchase medicines with home delivery options available. Sterispharma's mission is to supply a broad range of healthcare products to meet the diverse needs of the medical community. From advanced treatments and medications for rare conditions to essential health necessities, Sterispharma aims to serve the extensive demands of the healthcare industry. You can order medicines from Sterispharma through their websites, sterisonline and sterispharma. Their extensive product lineup includes treatments for Cardiology, Asthma, Respiratory Issues, Nasal Conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/Antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental Care, and Dermatology.

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