"ST-GLIPTIN M 50/500: Dual Action for Blood Sugar Control"

ST-GLIPTIN M 50/500 

Sitagliptin (50mg), Metformin SR 500

Introduction

Sitagliptin (50mg) and Metformin SR (500mg) is a combination medication used to effectively manage type 2 diabetes. This dual-action therapy combines the benefits of a dipeptidyl peptidase-4 (DPP-4) inhibitor and a biguanide, helping to control blood sugar levels, enhance insulin sensitivity, and improve overall glucose metabolism.

Mechanism of Action

Sitagliptin (50mg)

• Sitagliptin works by inhibiting the DPP-4 enzyme, which breaks down incretin hormones. Incretin hormones are crucial for regulating blood sugar levels as they increase insulin synthesis and release from pancreatic beta cells while decreasing glucagon production. By preventing the breakdown of these hormones, Sitagliptin enhances their action, leading to better blood sugar control.

Metformin SR (500mg)

• Metformin is a biguanide that reduces the amount of glucose produced by the liver. The sustained-release (SR) formulation ensures a steady release of the medication, providing prolonged glucose control. It also improves the body’s sensitivity to insulin, aiding in better glucose utilization and absorption.

Uses

• Type 2 Diabetes Management: This combination is primarily used to manage type 2 diabetes in adults, helping to control blood sugar levels and prevent complications associated with diabetes.
• Postprandial Glucose Control: The combination helps manage post-meal blood sugar spikes, providing more stable glucose levels throughout the day.

Dosage and Administration

The typical dosage is one tablet of Sitagliptin (50mg) and Metformin SR (500mg) taken once daily, usually with the evening meal to reduce gastrointestinal side effects and ensure optimal absorption. Regular blood sugar monitoring and follow-ups with your healthcare provider are essential to ensure the medication’s effectiveness.

Side Effects

Common side effects include:

• Nausea
• Diarrhea
• Headache
• Upper respiratory tract infections
• Hypoglycemia (low blood sugar)

Serious side effects may include:

• Lactic acidosis (a rare but serious complication of metformin)
• Pancreatitis (from sitagliptin)
• Severe allergic reactions

Precautions

• Kidney Function: Regular monitoring of kidney function is recommended, especially for patients with renal impairment.
• Liver Function: Patients with liver disease should use this combination cautiously.
• Hydration: Ensure adequate hydration to avoid dehydration.

Conclusion

Sitagliptin (50mg) and Metformin SR (500mg) offer a comprehensive approach to managing type 2 diabetes. By targeting different aspects of glucose metabolism, this combination helps maintain optimal blood sugar levels and improve overall health. Always follow your healthcare provider’s instructions and attend regular check-ups to ensure safe and effective treatment.Steris Healthcare Pvt Ltd, founded by a group of expert professionals in the pharmaceutical industry in February 2018, operates as Sterispharma. This company, which is based in Navi Mumbai, holds certifications from WHO, GMP, and ISO. Its commitment is to provide high-quality drugs at affordable prices to its customers throughout India, following the rigorous guidelines set by the WHO. Steris offers the convenience of an online pharmacy where customers can easily buy medicines and enjoy the benefit of home delivery. At Steris, the mission is to supply a wide array of healthcare products designed to meet the varied needs of the medical community. Whether it is advanced treatments, medications for rare conditions, or basic health necessities, Sterispharma strives to serve the healthcare industry’s broad demands. The extensive product lineup from Steris includes treatments for various health areas such as Cardiology, Asthma, Respiratory issues, Nasal conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental care, and Dermatology.

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