Ranolazine 1000mg Tablets: The Ultimate Guide for Patients

Introduction

Ranolazine 1000mg, marketed under the brand name RANOGEM ER 1000, is a prescription medication used for the treatment of chronic angina pectoris (chest pain) associated with coronary artery disease. It belongs to the anti-anginal class of drugs that work by improving blood flow and reducing oxygen demand in the heart. Unlike traditional anti-anginal medications that focus on lowering heart rate or blood pressure, Ranolazine primarily affects the sodium channels to improve heart function.

Key Ingredients

The active ingredient in RANOGEM ER 1000 is Ranolazine (1000mg). This extended-release tablet ensures a sustained effect, helping patients manage angina symptoms effectively throughout the day.

Key Benefits of Ranolazine 1000mg

• Reduces the frequency of angina attacks

• Enhances exercise tolerance in patients with chronic angina

• Improves blood flow to the heart

• Does not significantly affect blood pressure or heart rate

• Beneficial for diabetic patients as it may help in better glycemic control

• Can be used in combination with other anti-anginal medications for optimal results

How Does Ranolazine Work?

Ranolazine works by inhibiting the late sodium current (INaL) in cardiac muscle cells. This reduces intracellular sodium levels, leading to decreased calcium overload, which in turn improves myocardial relaxation and reduces oxygen consumption. Unlike beta-blockers or calcium channel blockers, Ranolazine 1000mg does not lower heart rate or blood pressure, making it a unique option for angina treatment.

Recommended Dosage of Ranolazine 1000mg

The usual starting dose of RANOGEM ER 1000 is 500mg twice daily, which may be increased to 1000mg twice daily based on clinical response and tolerance. The maximum recommended dose is 2000mg per day. It should be taken orally, with or without food, and should not be crushed, chewed, or split, as it is an extended-release formulation.

Special Dosage Considerations

• Elderly Patients: Dosage adjustment may be required based on kidney and liver function.

• Patients with Renal Impairment: Use with caution in patients with moderate-to-severe kidney disease.

• Patients with Liver Impairment: Contraindicated in patients with severe hepatic impairment due to increased drug levels.

• Concomitant Medications: Dose modifications may be needed when used with CYP3A inhibitors or inducers.

Side Effects of Ranolazine 1000mg

While RANOGEM ER 1000 is well-tolerated in most patients, some may experience side effects, including:

Common Side Effects:

• Dizziness

• Nausea

• Headache

• Constipation

Serious Side Effects (Seek Medical Attention):

• QT prolongation (irregular heartbeat)

• Severe dizziness or fainting

• Shortness of breath

• Swelling in lower limbs

• Severe liver or kidney dysfunction

Drug Interactions

Ranolazine 1000mg interacts with several medications. Some important drug interactions include:

• CYP3A inhibitors (e.g., Ketoconazole, Itraconazole, Clarithromycin) – may increase ranolazine levels.

• CYP3A inducers (e.g., Rifampin, Phenytoin, Carbamazepine) – may decrease the effectiveness of ranolazine.

• Antiarrhythmic drugs (e.g., Quinidine, Sotalol) – may increase the risk of QT prolongation.

• Digoxin – ranolazine may increase digoxin levels.

• Metformin – ranolazine can elevate plasma metformin levels, requiring dose adjustments.

Contraindications

Patients should avoid using RANOGEM ER 1000 if they have:

• Severe liver disease

• QT prolongation or history of torsades de pointes

• Allergy to Ranolazine or its components

• Severe kidney impairment

Precautions and Warnings

• Use in Pregnancy and Breastfeeding: There is limited data on the safety of Ranolazine 1000mg in pregnant and lactating women. It should be used only if clearly necessary under medical supervision.

• Driving and Operating Machinery: Due to the risk of dizziness and fainting, patients should avoid activities requiring alertness until they know how the drug affects them.

• Alcohol Consumption: Should be limited as it may increase side effects like dizziness.

Price and Availability in India

The cost of RANOGEM ER 1000 in India may vary depending on the pharmacy and location. On average, a strip of 10 tablets may range between ₹400 - ₹800. Patients are advised to check with local pharmacies or online drugstores for updated pricing and availability.

Frequently Asked Questions (FAQs)

1. Can I stop taking Ranolazine 1000mg suddenly?

No, stopping RANOGEM ER 1000 abruptly may worsen angina symptoms. Consult your doctor before making any changes to your medication.

2. Can Ranolazine be taken with food?

Yes, Ranolazine can be taken with or without food. However, grapefruit juice should be avoided as it can increase drug levels in the blood.

3. Is RANOGEM ER 1000 a blood thinner?

No, Ranolazine 1000mg is not a blood thinner. It works by improving heart metabolism and reducing angina symptoms without affecting blood coagulation.

4. How long does Ranolazine take to work?

Patients may experience symptom relief within a few hours to a few days after starting the medication. Full benefits are usually observed within a few weeks of consistent use.

5. Can diabetics take Ranolazine 1000mg?

Yes, Ranolazine is safe for diabetic patients and may even help in controlling HbA1c levels.

Conclusion

Ranolazine 1000mg (RANOGEM ER 1000) is a highly effective medication for the treatment of chronic angina, especially for patients who do not respond well to conventional beta-blockers or calcium channel blockers. Its unique mechanism of action provides relief from angina symptoms without significantly affecting blood pressure or heart rate. While generally safe, it is important to follow prescribed dosages, monitor drug interactions, and be cautious in patients with liver or kidney impairment. Always consult a cardiologist before starting RANOGEM ER 1000 to ensure it is the right medication for your condition.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

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