Sacubitril (24mg) and Valsartan (26mg): A Game-Changer in Heart Failure Treatment

Introduction

Heart failure is a life-threatening condition that impacts millions of people worldwide. To combat this chronic disease, advanced combination therapies have emerged that work synergistically to improve heart function and reduce hospitalizations. SACUSMART 50 is one such innovative medicine that contains Sacubitril (24mg) and Valsartan (26mg)—a fixed-dose combination widely prescribed for managing heart failure with reduced ejection fraction (HFrEF).

In this article, we’ll explore everything you need to know about SACUSMART 50, including its mechanism of action, dosage, uses, side effects, and commonly asked questions. We’ll also examine how this combination works to improve heart function and quality of life in patients.

About This Medication

SACUSMART 50 is a prescription medicine that contains a combination of two drugs:

• Sacubitril (24mg) – a neprilysin inhibitor

• Valsartan (26mg) – an angiotensin II receptor blocker (ARB)

Together, they offer dual inhibition of the renin-angiotensin-aldosterone system (RAAS) and enhancement of natriuretic peptide activity, making this combination a powerful and modern treatment for chronic heart failure.

This combination is also known as an angiotensin receptor-neprilysin inhibitor (ARNI) and is considered more effective than ACE inhibitors in reducing cardiovascular death and hospitalization due to heart failure.

Tablet Uses

SACUSMART 50 is mainly used for the following purposes:

• Treatment of Heart Failure with Reduced Ejection Fraction (HFrEF):
  It is prescribed to patients with chronic HFrEF to reduce the risk of cardiovascular mortality and heart failure-related hospitalizations.

• Improvement of Quality of Life in Heart Failure Patients:
  By reducing symptoms such as fatigue, breathlessness, and fluid retention, SACUSMART 50 can enhance daily functioning and overall well-being.

• Post-Heart Failure Hospitalization Therapy:
  This medicine is often used in stable patients who have recently been hospitalized due to heart failure.

Sacubitril Valsartan Mechanism of Action

The mechanism of action of Sacubitril (24mg) and Valsartan (26mg) is what makes this combination unique and superior to traditional therapies.

1. Sacubitril (24mg)

Sacubitril is a neprilysin inhibitor, which prevents the breakdown of natriuretic peptides—hormones that help reduce blood volume and pressure by promoting salt excretion and vasodilation. By inhibiting neprilysin, sacubitril enhances the body’s natural ability to fight fluid overload and high blood pressure.

2. Valsartan (26mg)

Valsartan is an angiotensin II receptor blocker (ARB) that prevents the effects of angiotensin II, a hormone that causes blood vessels to constrict. By blocking this hormone, valsartan reduces blood pressure and strain on the heart.

Dual Action – Powerful Heart Protection

This dual mechanism helps lower blood pressure, improve blood flow, reduce fluid retention, and ease the burden on the heart. It also counters neurohormonal activation, which is a key driver of heart failure progression.

Sacubitril Valsartan Dose

The typical starting dose of SACUSMART 50 is Sacubitril (24mg) and Valsartan (26mg), taken twice daily. The dose may be gradually increased under medical supervision based on patient response and tolerability.

Dose Adjustment Guidelines:

• Initiation: Start with SACUSMART 50 twice daily for patients not currently taking an ACE inhibitor or ARB.

• Titration: After 2–4 weeks, the dose may be increased to higher strengths if tolerated.

• Adjustment: Kidney function, blood pressure, and potassium levels should be monitored regularly.

Always follow your doctor’s instructions regarding dosage. Do not self-medicate or change the dose without consulting a healthcare professional.

What Are the Possible Side Effects of This Medicine?

While SACUSMART 50 is generally well-tolerated, it may cause side effects in some patients. Awareness of potential adverse effects is important to ensure safety and timely medical intervention.

Common Side Effects:

• Low blood pressure (hypotension): Dizziness or lightheadedness, especially when standing up suddenly.

• Increased potassium levels (hyperkalemia): May lead to muscle weakness or irregular heartbeats.

• Renal impairment: Reduced kidney function in some individuals.

• Fatigue or weakness: Due to reduced blood pressure or heart workload.

Less Common Side Effects:

• Cough

• Headache

• Nausea or abdominal discomfort

• Back pain

Serious Side Effects (Seek Medical Help):

• Severe allergic reactions (angioedema): Swelling of the face, lips, tongue, or throat—can be life-threatening.

• Marked drop in blood pressure

• Worsening kidney function

Always report any unusual symptoms to your doctor promptly. Never discontinue medication without medical guidance.

Frequently Asked Questions (FAQs)

1. What is SACUSMART 50 used for?

SACUSMART 50 is used to treat chronic heart failure with reduced ejection fraction (HFrEF). It helps improve survival, reduce symptoms, and prevent hospitalizations due to heart failure.

2. What is the mechanism of action of Sacubitril and Valsartan?

Sacubitril inhibits neprilysin to enhance natriuretic peptides, promoting vasodilation and salt excretion. Valsartan blocks angiotensin II receptors to lower blood pressure. Together, they protect the heart and improve cardiac function.

3. What is the typical dose of Sacubitril and Valsartan?

The usual starting dose is Sacubitril 24 mg / Valsartan 26 mg, taken twice daily. The dose may be adjusted over time based on response.

4. What are the common side effects of SACUSMART 50?

Some side effects include dizziness, low blood pressure, elevated potassium levels, and kidney function changes. Serious reactions like angioedema are rare but require urgent care.

5. Is SACUSMART 50 the same as Entresto?

Yes, SACUSMART 50 contains the same active ingredients as Entresto—Sacubitril (24mg) and Valsartan (26mg)—but is marketed under a different brand name.

6. Can SACUSMART 50 be taken with other heart medications?

Yes, but only under medical supervision. It may be combined with beta-blockers, diuretics, or mineralocorticoid receptor antagonists as part of comprehensive heart failure therapy.

7. Who should not take SACUSMART 50?

• Patients with a history of angioedema

• People taking ACE inhibitors (must stop ACE inhibitors 36 hours before starting SACUSMART 50)

• Those with severe liver impairment or hyperkalemia

8. How long should SACUSMART 50 be taken?

SACUSMART 50 is typically taken long-term as part of heart failure management unless side effects or contraindications arise.

Important Precautions

Before starting SACUSMART 50, inform your doctor if you have:

• Kidney or liver disease

• Low blood pressure or dehydration

• High potassium levels

• History of allergic reactions or angioedema

• Are pregnant or breastfeeding

This medication should be avoided during pregnancy as it may harm the unborn baby.

Storage and Handling

• Store SACUSMART 50 in a cool, dry place below 30°C.

• Keep it away from direct sunlight and moisture.

• Keep out of reach of children.

• Do not use the medicine past its expiry date.

Final Thoughts

SACUSMART 50, containing Sacubitril (24mg) and Valsartan (26mg), is a revolutionary approach to managing chronic heart failure with reduced ejection fraction. By combining the effects of neprilysin inhibition with angiotensin receptor blockade, it addresses the pathophysiological complexity of heart failure more effectively than traditional medications.

From reducing mortality to preventing rehospitalizations, SACUSMART 50 has emerged as a gold-standard therapy in modern cardiology. However, it is essential to take this medication exactly as prescribed, monitor for side effects, and attend regular follow-ups to ensure optimal outcomes.

If you or a loved one is living with heart failure, speak to a cardiologist about whether SACUSMART 50 could be the right treatment option. With proper use, it can greatly improve quality of life and long-term heart health.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

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