Sacubitril (24mg), Valsartan (26 mg)

sacubitril valsartan

Introduction

Sacubitril/Valsartan, marketed under brand names like SACUBRIGHT 50, is a novel fixed-dose combination drug used in the treatment of chronic heart failure with reduced ejection fraction (HFrEF). Sacubitril (24mg), Valsartan (26 mg) belongs to a unique class called ARNI (Angiotensin Receptor–Neprilysin Inhibitors) and is widely accepted as superior to traditional ACE inhibitors in eligible patients.

Composition

Each SACUBRIGHT 50 tablet contains:

• Sacubitril – 24 mg

• Valsartan – 26 mg
  Totaling a 50 mg combined dose, this formulation is designed for twice-daily oral use.

Mechanism of Action

This dual-action medication works synergistically:

• Sacubitril inhibits neprilysin, leading to increased levels of natriuretic peptides, which help reduce blood pressure and cardiac stress.

• Valsartan, an angiotensin II receptor blocker (ARB), prevents vasoconstriction and reduces fluid retention.

Together, they provide better control of heart failure symptoms, reduce hospitalizations, and improve survival outcomes.

Therapeutic Uses

In English:

• Heart Failure with Reduced Ejection Fraction (HFrEF)

• Improves survival and reduces re-hospitalization

• In select cases, may be used post-myocardial infarction (off-label)

In Hindi (सैक्युबिट्रिल वल्सार्टन टैबलेट के उपयोग):

• हृदय की कार्यक्षमता कम होने पर (Heart Failure – HFrEF)

• रोगी को बार-बार अस्पताल में भर्ती होने से बचाने के लिए

• जीवन की गुणवत्ता में सुधार के लिए

Dosage and Administration

• Initial Dose: SACUBRIGHT 50 (24/26 mg) twice daily

• Titration: Increase to 100 mg or 200 mg twice daily based on tolerance

• Special Note: If switching from an ACE inhibitor, maintain a 36-hour washout period before starting.

Common Side Effects

• Low blood pressure

• High potassium levels

• Dizziness

• Kidney function changes

• Rare but serious: Angioedema (facial/tongue swelling)

Precautions

• Avoid in pregnancy and lactation

• Regular monitoring of blood pressure, kidney function, and electrolytes is essential

• Not to be used with ACE inhibitors or aliskiren in diabetics

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Frequently Asked Questions (FAQ) – SACUBRIGHT 50

Q1. What is SACUBRIGHT 50 used for?

SACUBRIGHT 50 is used to treat heart failure with reduced ejection fraction (HFrEF). It helps improve heart function, reduce the risk of hospitalization, and prolong survival.

Q2. How should SACUBRIGHT 50 be taken?

Take SACUBRIGHT 50 twice daily, with or without food. It should be taken at the same times every day for best results. Do not stop or skip doses without consulting your doctor.

Q3. Can I take SACUBRIGHT 50 if I’m already on an ACE inhibitor?

No. You must wait at least 36 hours after stopping an ACE inhibitor before starting SACUBRIGHT 50 to reduce the risk of angioedema (serious allergic reaction).

Q4. What are the common side effects of SACUBRIGHT 50?

Common side effects include:

• Low blood pressure (hypotension)

• Increased potassium levels (hyperkalemia)

• Dizziness or fainting

• Impaired kidney function

• Rarely: facial or throat swelling (angioedema)

Q5. Is SACUBRIGHT 50 safe during pregnancy or breastfeeding?

No. SACUBRIGHT 50 should not be used during pregnancy as it may harm the fetus. Its safety during breastfeeding is also not well established.

Q6. Do I need any tests while using SACUBRIGHT 50?

Yes. Your doctor may regularly monitor your:

• Blood pressure

• Kidney function (creatinine)

• Potassium levels

Conclusion

Sacubitril-Valsartan (SACUBRIGHT 50) is a proven, life-saving therapy for heart failure patients. It works by combining two powerful mechanisms to lower blood pressure, reduce cardiac strain, and improve long-term outcomes. When produced and handled under high-quality standards—as offered by leading providers like Steris—patients and healthcare providers can be assured of both safety and efficacy.