Sirolimus (1.0mg) & SIROLIME 1:Tablet- View Uses, Side Effects, Dosage, Mechanism of action...

Sirolimus (1.0mg) & SIROLIME 1

Sirolimus (1.0mg) is an immunosuppressive drug SIROLIME 1 primarily used to prevent organ rejection in patients who have undergone kidney transplant surgery. This article provides detailed information on its uses, side effects, dosage, and mechanisms of action, offering valuable insights for patients and healthcare providers.

Uses

Sirolimus (1.0mg) is primarily prescribed for:

• Prevention of Organ Rejection: It is used to prevent rejection of kidney transplants by suppressing the immune system.
• Treatment of Lymphangioleiomyomatosis (LAM): Sirolimus is used to treat this rare lung disease, which affects women of childbearing age.

Side Effects

Common side effects of Sirolimus (1.0mg) may include:

• Increased Risk of Infections: Due to its immunosuppressive effects, patients may be more susceptible to infections.
• Hyperlipidemia: Elevated levels of cholesterol and triglycerides can occur.
• Anemia and Thrombocytopenia: Reduced levels of red blood cells and platelets.
• Mouth Ulcers: Painful sores in the mouth are a frequent side effect.
• Delayed Wound Healing: The drug can impair the healing process of wounds.

Severe side effects are rare but can include severe allergic reactions, liver damage, and lung issues. Immediate medical attention is required if these occur.

Dosage

The dosage of Sirolimus (1.0mg) varies based on the condition being treated and patient-specific factors. General guidelines include:

• Kidney Transplant: The initial dose is usually 6 mg, followed by a maintenance dose of 2 mg per day. Dosage adjustments are based on blood test results and patient response.
• LAM: The typical dose is 2 mg per day, but the healthcare provider may adjust it based on individual patient needs.

Patients should follow the prescribed dosage and not exceed the recommended amount without consulting a healthcare provider. It is usually taken once daily, with or without food, but should be consistently taken the same way each day.

Mechanism of Action

Sirolimus works by:

• Inhibition of mTOR: Sirolimus inhibits the mammalian target of rapamycin (mTOR), a key protein involved in cell growth and proliferation. This action suppresses the immune system, reducing the risk of organ rejection.
• Reduction of T-cell and B-cell Activity: By inhibiting mTOR, Sirolimus decreases the activity of T-cells and B-cells, which are crucial for immune response. This helps prevent the immune system from attacking the transplanted organ.

Conclusion

Sirolimus (1.0mg) is an effective medication for preventing organ rejection in kidney transplant patients and treating LAM. Understanding its uses, potential side effects, proper dosage, and mechanisms of action can help ensure safe and effective treatment. For personalized advice and optimal results, consulting with healthcare professionals is recommended. Steris Healthcare Pvt Ltd, established in February 2018 by seasoned professionals in the pharmaceutical sector, operates under the name Sterispharma. Headquartered in Navi Mumbai, the company is certified by WHO, GMP, and ISO. Sterispharma is dedicated to providing high-quality medications at affordable prices across India, adhering to stringent WHO guidelines. They offer an online pharmacy platform for easy medicine purchases and home delivery. The company's mission is to deliver a diverse range of healthcare products catering to the varied needs of the medical community. From advanced treatments and rare condition medications to essential health supplies, Sterispharma aims to meet the extensive demands of the healthcare industry. Their product range covers numerous health fields, including Cardiology, Asthma, Respiratory issues, Nasal conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental care, and Dermatology.

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