Teneligliptin 20 mg + Metformin SR 500 mg

Introduction

In the realm of managing type 2 diabetes mellitus (T2DM), pharmaceutical solutions that effectively control blood sugar levels are crucial in preventing long-term complications such as heart disease, nerve damage, kidney problems, and vision loss. TENELIGOLD M 500, a combination of Metformin SR (500mg) and Teneligliptin (20mg), is one such effective treatment option. This formulation leverages the synergistic effects of its active ingredients to offer a comprehensive approach to blood glucose management.

Metformin, a widely used medication, has been a cornerstone in treating type 2 diabetes for decades. It primarily works by improving the sensitivity of the body’s cells to insulin and reducing the liver’s production of glucose. On the other hand, Teneligliptin, a newer drug in the class of DPP-4 inhibitors, aids in regulating blood sugar by increasing the levels of incretin hormones, which stimulate insulin production and inhibit glucagon release after meals.

When used in combination, Metformin SR (500mg) and Teneligliptin (20mg) provide enhanced glycemic control, making TENELIGOLD M 500 a powerful option for patients whose diabetes is not adequately controlled with monotherapy. In this article, we will explore the key ingredients of TENELIGOLD M 500, its mechanism of action, uses, dosage, side effects, and its potential benefits in managing type 2 diabetes.

Key Ingredients

Metformin SR (500mg)

Metformin is the first-line treatment for type 2 diabetes, particularly effective in overweight or obese individuals. It works mainly by reducing hepatic glucose production, which is often elevated in diabetic individuals, and by improving insulin sensitivity in muscle and fat tissues. This action results in a reduction in blood glucose levels, which is critical in managing diabetes.

• Extended-Release Formulation (SR): Metformin SR, or extended-release Metformin, is designed to be released slowly into the bloodstream over time. This formulation helps reduce gastrointestinal side effects such as nausea and diarrhea, which are common with immediate-release Metformin, making it easier for patients to tolerate.

Teneligliptin (20mg)

Teneligliptin belongs to a class of drugs known as Dipeptidyl Peptidase-4 (DPP-4) inhibitors. It works by inhibiting the enzyme DPP-4, which breaks down incretin hormones. Incretins, such as GLP-1 (glucagon-like peptide 1) and GIP (gastric inhibitory polypeptide), help regulate blood sugar levels by enhancing insulin secretion from the pancreas in response to meals and suppressing glucagon release, which otherwise promotes glucose production in the liver.

• Action of Teneligliptin: By preventing the breakdown of incretin hormones, Teneligliptin prolongs their activity, helping to maintain better control over blood sugar levels post-meal and throughout the day.

How Does TENELIGOLD M 500 Work?

TENELIGOLD M 500 combines the blood sugar-lowering effects of Metformin SR with the insulin-regulating action of Teneligliptin. Together, they provide a dual mechanism of action to effectively control blood glucose levels in type 2 diabetes patients.

1. Metformin SR’s Role:

   • Decreases hepatic glucose production.
   • Improves insulin sensitivity in muscles and adipose tissue, allowing for more effective glucose uptake.
   • Slows down the absorption of glucose from the intestines.
   • Reduces the risk of insulin resistance, one of the primary underlying issues in type 2 diabetes.

2. Teneligliptin’s Role:

   • Increases insulin secretion in response to meals.
   • Suppresses the release of glucagon, which prevents the liver from producing excess glucose.
   • Enhances postprandial (post-meal) glucose control, which is particularly beneficial in preventing the blood sugar spikes that often occur after eating.

By combining these two mechanisms, TENELIGOLD M 500 helps in maintaining stable blood sugar levels throughout the day, reducing both fasting and postprandial glucose levels. This combination therapy also offers the advantage of minimizing the risk of long-term diabetes complications.

Uses of TENELIGOLD M 500

TENELIGOLD M 500 is primarily indicated for the treatment of type 2 diabetes mellitus in adults, especially for those whose blood glucose levels are not adequately controlled with lifestyle modifications, diet, or metformin monotherapy. It is often prescribed when diet, exercise, and metformin alone are insufficient in controlling blood glucose levels.

TENELIGOLD M 500 can be used:

• As an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes.
• As a substitute for monotherapy when patients are not achieving optimal control with Metformin alone.
• In combination with other oral hypoglycemic agents (under the supervision of a healthcare provider) when additional control is necessary.

While TENELIGOLD M 500 is an effective treatment for managing type 2 diabetes, it is not intended for the treatment of type 1 diabetes or diabetic ketoacidosis, which require different management strategies.

Dosage and Administration

The typical dosage of TENELIGOLD M 500 is one tablet taken orally once a day, preferably with a meal to reduce the risk of gastrointestinal side effects. The exact dose may vary depending on the patient's individual requirements and the prescribing doctor’s recommendations.

Starting Dose:

• If a patient has not previously been treated with Metformin or Teneligliptin, the usual starting dose is one tablet of TENELIGOLD M 500 per day.

Dose Adjustments:

• If necessary, the dosage may be adjusted by the healthcare provider depending on the patient's glycemic response and tolerance to the medication.
• For patients already on Metformin or Teneligliptin, the dosage of TENELIGOLD M 500 may be initiated at an appropriate level based on previous doses.

It is important for patients to follow their healthcare provider’s instructions regarding the dosage and administration of TENELIGOLD M 500 and to never alter the dose without consulting their doctor.

Side Effects of TENELIGOLD M 500

As with any medication, TENELIGOLD M 500 may cause side effects, although not everyone will experience them. The side effects can range from mild to more serious, and in some cases, they may require medical attention. Below are some of the potential side effects:

Common Side Effects:

• Gastrointestinal issues such as nausea, vomiting, diarrhea, or stomach upset, especially when starting Metformin. These can often be minimized by taking the medication with food.
• Headache or dizziness.
• Fatigue or tiredness, which may occur due to the blood sugar-lowering effects.

Less Common Side Effects:

• Hypoglycemia (low blood sugar), particularly if taken with other diabetes medications that increase insulin levels.
• Skin reactions such as rashes or itching.

Serious Side Effects:

• Lactic acidosis, a rare but serious condition caused by a buildup of lactic acid in the blood, which can be life-threatening. Symptoms include weakness, dizziness, unusual muscle pain, difficulty breathing, and irregular heartbeat. This is more common in individuals with kidney problems, liver disease, or other serious medical conditions.
• Pancreatitis (inflammation of the pancreas), which may present as severe abdominal pain, nausea, and vomiting.

Patients should contact their doctor if they experience any unusual or severe symptoms while using TENELIGOLD M 500.

Benefits of TENELIGOLD M 500

The combined action of Metformin SR and Teneligliptin offers several key benefits for individuals with type 2 diabetes:

• Effective Glycemic Control: The combination of these two drugs provides robust blood sugar control, both in the fasting state and after meals, which is essential for preventing complications associated with diabetes.
• Reduced Risk of Complications: By maintaining stable blood glucose levels, TENELIGOLD M 500 helps lower the risk of developing long-term diabetes complications such as cardiovascular disease, nerve damage, and kidney disease.
• Convenient Dosing: The extended-release formulation of Metformin allows for once-daily dosing, improving patient compliance with treatment.
• Synergistic Action: The combination therapy provides complementary effects that address different aspects of glucose regulation, offering a more comprehensive treatment than monotherapy.

Conclusion

TENELIGOLD M 500, with its active ingredients of Metformin SR (500mg) and Teneligliptin (20mg), is a potent treatment for managing type 2 diabetes. By combining the blood sugar-lowering effects of Metformin with the insulin-regulating action of Teneligliptin, this medication helps patients achieve better glycemic control, thereby reducing the risks of diabetes-related complications. With proper dosage, monitoring, and lifestyle changes, TENELIGOLD M 500 can be an essential part of a comprehensive diabetes management plan, enabling individuals to live healthier lives while managing their condition effectively. Always consult a healthcare professional before starting or adjusting diabetes medications to ensure the best possible outcomes.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

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